Infectious Malaria Sporozoites Produced Without Mosquitos Provide Ground-Breaking Progress For Malaria Vaccines And Biology Research

Scientists from Sanaria Inc., and collaborators at multiple institutions publish results in Nature reporting “In vitro production of infectious Plasmodium falciparum sporozoites.”

Sanaria® Plasmodium falciparum (Pf) sporozoites (SPZ) vaccines have conferred the highest protective efficacy against Pf infection and longest durability of protective efficacy without boosting of any malaria vaccine. PfSPZ vaccines are currently manufactured in mosquitoes under conditions that meet international regulatory standards. “By developing the capacity to produce infectious PfSPZ in vitro, meaning in culture vessels without the need for mosquitoes, we have made the critical, first, breakthrough steps for enabling manufacturing scale up to eventually meet the needs of the hundreds of millions to billions of people, especially those at high risk in Africa, who would benefit from our PfSPZ vaccines” said Dr. Stephen L Hoffman, Sanaria’s CEO. The importance of this high impact article is already being recognized in significant citations and press coverage outside the scientific community (see links below) and Dr. Hoffman adds “We are focused now on further improving the technology to bring it to compliance for human use and are actively seeking investment to move us forward as rapidly as possible.”

The ability to culture the malaria parasite’s blood stages, that cause disease and transmit to the mosquito was hugely influential in progressing our understanding of parasite biology and providing essential tools for vaccine development. “The capacity to routinely produce PfSPZ in vitro is equally game-changing” said Dr. Pedro Alonso, Professor of Global Health, University of Barcelona, and previous Director of the Global Malaria Program at the World Health Organization, “as it will accelerate our ability to interrogate the biology of this poorly understood stage of the malaria parasite that is normally transmitted to people through the bites of infected mosquitoes.” The paper describes, for the first time, completion of the Pf life cycle without the need for mosquitoes and characterizes the comparative biology of in vitro PfSPZ with those produced in mosquitoes at cellular, molecular and functional levels through gene expression-, antigen expression-, morphological- and infectivity studies.

“We are proud of the contributions of our malaria vaccine research team led by Dr. Stefan Kappe in the Center for Global Infectious Disease Research on this ground-breaking work,” added Dr. Eric Tham, senior vice president and chief research operations officer at Seattle Children’s. “We look forward to exploring future collaborations with Sanaria, building on this technology to produce highly protective, genetically attenuated PfSPZ vaccines.”

Sanaria’s mission has always been to develop, manufacture, license and deploy PfSPZ vaccines that are highly protective against infection as tools for control and the eventual elimination of a parasitic disease that is responsible for more than 600,000 deaths per year, mostly in children in Africa, that differentially adversely affects pregnant women on the continent, and is responsible for uncountable numbers of hospitalizations, days lost to illness, and billions of dollars spent on control and treatments. Professor Marcel Tanner, President of the Swiss Academy of Arts and Sciences, emphasized the importance of this major report, saying that “the methodologies presented in this pivotal publication pave the way for Sanaria to truly address this unmet need with technologies that are not only scalable but readily transferrable to any country in the world wanting to manufacture PfSPZ vaccines, making production of a malaria vaccine in Africa for Africans a realistic possibility.”

Links:
https://www.cell.com/trends/parasitology/fulltext/S1471-4922(22)00316-6
https://www.the-microbiologist.com/news/-scientists-produce-infectious-malaria-sporozoites-without-mosquitoes-offering-game-changer-for-vaccine/459.article
https://www.the-scientist.com/news-opinion/in-vitro-malaria-sporozoite-production-may-lead-to-cheaper-vaccines-70909
https://von.gov.ng/3-dose-malaria-vaccine-set-to-revolutionise-malaria-prevention-in-africa/

Forward Looking Statement
Except for historical information, this news release contains certain forward-looking statements that involve known and unknown risk and uncertainties, which may cause actual results to differ materially from any future results, performance or achievements expressed or implied by the statements made. Such statements include the availability of an effective vaccine, the expectations for conquering malaria, beliefs concerning the suitability of a successful vaccine, and the establishment of a path toward prevention of infection. These forward-looking statements are further qualified by important factors that could cause actual results to differ materially from those in the forward-looking statements.

https://www.vanguardngr.com/2023/02/scientific-research-gets-ground-breaking-progress-on-malaria-vaccines/

They have come with another one again o

Wahala

Haha

The world is evolving, but APC and their supporters are taking Nigeria 100 years back. They will surely fail.

Which kain wahala be this one again?

just to make our world a better place.

They have started again o. This was how corona started in the lab

K

Take at you own risk? If you believe there can be vaccine against a protozoan then Yiu will soon believe there is a vaccine against tapeworm

NotKnown:
They have come with another one again o

come again with what?

Good one.our youths here in Africa are busy attending Sunday school,casting and binding as all thier uncle's and aunties have become pastors...

Vaccine mandates for Africa this year isn't a joke after all

sircatherine45:
come again with what?

person wey no read article

We don see enough shege already

Liars. They won't mention the failed mosquito tests in Africa and Brazil where they introduced them again.
They'd only come up with reasons to quarantine or bill us (on travels etc)

people in general are always skeptical about vaccines...

but that's what happens when you aren't trying to survive against smallpox, polio and the bubonic plague;
it gives you plenty of time to discredit the importance of vaccines.




fun fact: for some reason, no coastal sub Saharan African tribe developed vessels capable of ocean navigation; but they all had gods based on the ocean.

Una don start abi
Sha don't give us super bug..

Test your hypothesis in your coy..don't bring the nonsense come Africa

genkins:
Good one.our youths here in Africa are busy attending Sunday school,casting and binding as all thier uncle's and aunties have become pastors...

No, the simple reason why we cannot do advanced research in Nigeria and in Africa is money...and facilities, and electric power. Not religion. I doubt the local Imam, or revenred bothers himself or herself about what they do in our research facilites self.

Once, a university in the UK got a grant of 600m pounds for research into Malaria. Tell me, who would give a university in Nigeria that money? In naira.?

The reason why we cannot do research is because of lack of money. Foreign countries have a lot of money to fund advanced research because they pay the kind of taxes and have the kind of tax to gdp ratio to pay for good universites, plus they pay tons of fees...even going into debt to do so. (at least in Nigeria, no one graduates with millions in debt), and they also pay their electricity and power bills on time, and don't subsidise education.

Here in Nigeria, we pay fees of less than 200 dollars a year, and somehow expect to do research that a university that has fees of up to 20000 dollars a year does? Like how? 40% of us don't pay power bills that are already very low...and yet we expect power 24/7 with what money? You don't pay the type of tax they pay in developed countries...and you expect good facilites and so on? And finally...you rely on something that at best can give you one third of what we actually need in revenue...and you expect to live like the developed nations?

You are here blaming religion. Some will blame athiests, some will blame FESTAC 77 for bringing in demons into the country, and some will blame the West. Yet, we will go and cheer as someone wakes up and says that we should chase away power companies officials from dealing with power defaulters because they are exploiting us. Or we would go and protest when it is time to remove fuel subsides...or we would go and cry oppression, when fees need to be raised, or the tax to gdp ratio needs to be expanded


Yet we want what the whites have at a fraction of the revenue.


Stop blaming religion. There are scientists who are religious and do extensive research. Just as there have been atheists who misapply research. But the thing is, all of us...the religious and the atheistis, and the traditionalists in this country.....have to work towards making our country's less dependent on oil and more dependent on industries, and also pay our power bills, and stop pretending that N400 can buy something that costs 4million, and maybe, just maybe...we may be able to develop the ultimate cure for malaria.


So, stop looking for bogeymen.

Them dey craze

Other countries are doing wonders...with groundbreaking results.

Nigeria is stuck between old men, looting away their future.

Worst of it is the youth cheering them.

Science with their findings. Make una no craze one day

This is wonderful. Someone is getting skeptical about this great work of science. Since our body could not generate antibodies against the developed protozoan that causes malaria. Would it develop antibodies against the sporozite?

I just admire the brilliance of science and scientists

Black man waiting on the White man to find a solution to a problem that bothers the Blackman. We've got bubbling teams of enthusiastic scientist but Zero equipment and Technical Know how. Pathetic.

The should better not release it like they did with COVID.

Long story short:
They can now produce malaria in the laboratory.
This more bad news as it is good news.
Watch as Bill Gates and his gang will "donate" to the production and distribution of the vaccine so they can buy it over and turn it to a lethal weapon of depopulation against Africa.

adioolayi:
Una don start abi
Sha don't give us super bug..

Test your hypothesis in your coy..don't bring the nonsense come Africa

As if Africa is capable of helping herself.