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Nairaland Forum / Nairaland / General / Health / Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? (58716 Views)
Is It Possible For A Hiv Positive Man Not To Pass It To His Wife? / Help! His Genotype Is AA And His Wife's Genotype Is AS But Their Daughter is SS / Please Explain Genotype AA (2) (3) (4)
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Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by Jabodo(m): 8:06pm On Jun 26, 2015 |
dedugbaa: Pleeaaasee is it possible for One's genotype to change! Four years ago, I did a test at Unilag Medical center and I was AA but a few months ago I did another test And the result was AS. What have I been doing wrong? |
Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by ChelseaDr(m): 8:11pm On Jun 26, 2015 |
adamshuaib: SC exists... it is a variant of sickle cell disease just like sickle cell anaemia (SS) anx thalasaemias... people with SC are less prone to crises unlike SS genotype OP if your mum is AA dad AS they can only produce AA and AS in equall proportions (50%) and not SC (you). this can only happen if your dad were to be AC which is the most likely scenerio considering that fact that many labs cannot be trusted with such technical interpretation....my advice is go to a teaching hospital with your parents and end it there.....best of luck bro |
Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by raziboi(m): 8:23pm On Jun 26, 2015 |
just like a revelation .....mayb ur real parents were AS ....u wia switched .... |
Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by Nobody: 8:29pm On Jun 26, 2015 |
alabiyemmy:very true fact... the op should read up a work done by Aristotle about breeding ( pdf). |
Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by abbey621(m): 8:41pm On Jun 26, 2015 |
dagbokoncept: While I agree with you about genetic mutation, I have to disagree with you that mutation is the only possible explanation. Human error might have a huge role to play in this scenario, I would suggest the OP get a second, third and even fourth opinion from bigger labs. |
Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by lat55(f): 8:44pm On Jun 26, 2015 |
Contrary to public opinion, I doubt there was foul play on the side of your parents. My reasons are, if your parents knew they were not clean, they won't follow you to get tested twice esp after the first result. It's most likely that you were switched at birth, you have to calmly investigate the matter. It's important you stay calm so you can make smart decisions. All the best hun |
Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by bukhety(f): 8:50pm On Jun 26, 2015 |
I've seen a situation where someone had always thought she was AA, only to do the genotype test as part of medical requirement at the Uni, and to be told she was AC. She went home to discuss this wit her family (because they are all confirmed AA), only for her sis to narrate the same experience at work, that a new test shows she is AC and nt AA as they previously thought. The only logical conclusion I can see in this situation is that perhaps the mum is AC and the dad is AS. That might explain hw they beget SC. 1 Like 1 Share |
Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by Nobody: 8:52pm On Jun 26, 2015 |
Very possible your mum is Ac.you Ve to double check the result.and u pick the SC. 1 Like |
Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by kalebsky: 8:58pm On Jun 26, 2015 |
Leem4: The hemoglobin (Hb) SC genotype is seen in persons who have inherited the gene for hemoglobin S from one parent and the gene for hemoglobin C from the other. Some people with this genotype develop Hb SC disease, a variant of sickle cell disease. Hb SC disease, a compound heterozygous condition, is the most common of the hemoglobinopathies and the least severe, although it is still serious. I also have a nephew who is SC genotype... don't listen to people who are not scientific inclined that their might be conspiracy |
Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by kalebsky: 9:02pm On Jun 26, 2015 |
UR mum should be AC... she should go to well defined modernized laboratories and not 19th centuries Laboratory that still thinks we have only 3 genotype group... [color=#006600][/color] |
Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by marciano3d: 9:15pm On Jun 26, 2015 |
adamshuaib: Oga there is SC , I'm AC I even read that there is AD and there will be more mutations allowing possibilities like AE AF AG AH AI 1 Like |
Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by aaidel(m): 9:17pm On Jun 26, 2015 |
simply put the woman is not your mother for you to be SC you have to inherit one of each from each parent your father is AS so thats where you got the S from the C must be from somewhere and since your mum is AA there is no way it came from her repeat the test a third time and confront your dad possibly in the absence of your mum IMHO though parents are those who raised you and love you not those who you share biological traits with |
Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by marciano3d: 9:19pm On Jun 26, 2015 |
Jabodo: Get a second test done. One of the is an error. Ur genotype can never change It is part of ur body's blue print. |
Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by aimeeworship: 9:21pm On Jun 26, 2015 |
@Leem4 It is possible to be SC when your mum is AA and your dad AC. Most electrophoretic genotype machines used in routine laboratory only ascertain the A, S, C and rarely F bands based on the quality of the band. There are different sub-types: adult haemoglobin (Hb A), minor adult haemoglobin (Hb A2), sickle haemoglobin ( Hb S or C caused by a variant of the beta -globin gene) and foetal haemoglobin (Hb F is usually present in foetus and remains up to 6 months after birth). Hb S or C are the mutated form which reduces the normal plasticity of host erythrocytes (red blood cell) causing hemoglobinopathy (abnormality in the blood). Patients with Hb SS and Hb SC give similar clinical presentation. Using the HPLC (high performance liquid chromatography) machine (mostly seen in research labs) gives the genotype result based on quantity mostly indicated in percentage. Every individual having either Hb AA, AS, AC, SS and SC have other subgroups but in minor percentage. For example, Mum: may have Hb A as 41%, Hb A2 as 30%, Hb C as 18%, Hb S as 10% and Hb F as 1%. The two Hb with the highest percentage value is taken as the genotype = HbAA Dad: may have Hb A as 37%, Hb C as 31%, Hb S as 25%, Hb A2 as 5% and Hb A2as 2%. The two Hb with the highest percentage value is taken as the genotype = HbAC You: The genetic combination at which your genotype is random (I think God alone knows the perfect combination) but it revolves within these percentages written above for both the father and mother. You may have Hb S as 34%, Hb C as 30%, Hb A as 24%, Hb A2 as 11% and Hb F as 1%. The two Hb with the highest percentage value is taken as the genotype = Hb SC With this illustration, you could have the other Hb variables but in minimal amount. Regular laboratory tests will not give this details. Any need for HPLC tests, I can ... . ? 1 Like |
Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by YEM101: 9:22pm On Jun 26, 2015 |
Pls do a DNA test to be sure they re ur real parents. |
Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by marciano3d: 9:34pm On Jun 26, 2015 |
K |
Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by marciano3d: 9:34pm On Jun 26, 2015 |
dagbokoncept: According to what I read AS exist as West African's red blood cells had to mutate to combat malaria so there are now AC and AD which have to start 4rm someone I'm AC, my mom told me since I was a kid and all d labs ive used comfirm it, So if mutation doesn't work where did AC come from The malaria theor seems to be true because an AA friend that was hospitalised 4 malaria and we jointly did lab test 4 malaria, we had d same Asterix 4 presence of malaria parasite in our blood whereas he was d only one dat showed symptoms. She fit be MUTANT 1 Like |
Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by bowei(m): 9:44pm On Jun 26, 2015 |
Very possible mutation just occurred 1 Like |
Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by ridgeman: 9:53pm On Jun 26, 2015 |
Get a proper test done in a proper lab for your parents and siblings. Hopefully this time the results make sense. if not then it's possible a switch happened at birth or your folks adopted you. I'd the latter then the may know who your real parents are either way from what you've said they care for you very dearly at least you haven't shared any negative experiences. Goodluck I hope you find peace |
Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by cahnellven: 10:09pm On Jun 26, 2015 |
Got this from Facebook The AS AC SC SS and CC genotype. What you have in your blood are cells, the most predominant of which are called RED BLOOD CELLS (RBCs). These cells contain within them HEMOGLOBIN, a substance without which the RBCs are invariably useless. This hemoglobin itself is composed of 2 parts: a heme (don't bother yourself, this basically is a complex Iron- protein complex) and globin (2 pairs of protein chains, this is the important part). There are 2 alpha and 2 beta globin chains - the pair, and there is a normal way the chains are supposed to be structured. The error happens when a protein substitution occurs in any one of these chains - but particularly in the globin chains (First of all, you have to understand that amino acids are the building blocks of proteins - so if amino acid 'x' is the normal, an abnormality occurs when instead of 'x' at a particular location along the chain, you have 'y'.) That is as simple as it gets. These errors of substitution are given the big name of 'THALASSAEMIAS'. In reality, a substitution will occur at any point along either the alpha or beta chains but for the purposes of simplicity and to answer your question, we focus on the genotypes AS, SS, AC. Genotype AA: At position 6 of both globin chains,the amino acid is GLUTAMATE Genotype AS: At position 6 of one globin chain is GLUTAMATE and at position 6 of the second globin chain, you have VALINE Genotype SS: At position 6 of both globin chains, the amino acid is VALINE Genotype AC: At position 6 of one globin chain is GLUTAMATE and at position 6 of the second globin chain, you have LYSINE There are different types of Hemoglobin; among them are Hemoglobin A, Hemoglobin S and Hemoglobin C. Hemoglobin C is very rare. Everyone must have a pair of these hemoglobin in their blood, each inherited from both parents. The pairing might be in any of the following formations: AA, AS, AC, SC,SS OR CC. A man with AA can marry anyone without any problem (medically); likewise the woman. How do people get their genotypes? Simple, from your biological parents. If papa bomboy has a genotype AA and mama bomboy has a genotype AS, which genotype do their children have? What we do in theory is this, you cross each of those letters so that you have AA, AS, AA, AS? Therefore, for each pregnancy and each bomboy they delivery has a 50:50 probability of being AA or AS. What if their genotypes were AA (for papa bomboy) and SS (for mama bomboy); you do the crossing again: AS, AS, AS, AS. Therefore, it is very UNLIKELY that any of their children will have a genotype outside of AS. You will see that I have used the word unlikely because poo happens. They might end up having a child who is either completely AA or SS but whatever happens, a child's genotype is never outside of the parents. Eg. a man and woman who are both AA can never have children with genotype starting or ending with 'S'. If it happens, either your landlord or next door neighbours are highly involved (just kiddin Oluwa isn't involved'). So for you to get C, you must have a parent who carries a 'C' in his or her genotype. Likewise the S must have a parent with S genotype One more thing: Are there any clinical features of Hemoglobin C like Hemoglobin S? In the case that you're AC, well the good news is that MOST TIMES THERE ARE NO SYMPTOMS, but occasionally, there is JAUNDICE. THE BEST PART IS THAT YOU CAN LIVE A NORMAL LIFE WITH AC!!! And just for the case of mentioning genotypes, you could have: Regular Genotype: AA (healthy as healthy can be) Traits: AC, AD, AF, AG, A+FAST, AE and AS (not associated with any clinical signs, symptoms or syndromes - they as relatively as healthy as AA) Genotypes associated with clinical features: SS, SC, CC (are associated with clinical signs, symptoms and syndromes) •Please note that the marriage thing is this, we really don't know what the recent trend is but the important thing is to make sure your genotype of you and your partner don't match up in a way as to produce an children with SS, SC and CC. These children only suffer for nothing!!! You can't even begin to compare the differences in severity between CC and SS disease, Symptoms of Hemoglobin C dsx (CC) Most people do not have symptoms. Occasionally, jaundice may occur. Complications of Hemoglobin C dsx Sometimes, they may experience the following: Cholelithiasis (gall stones that may require treatment) Splenomegaly (big spleen) Angloid streaks (causing poor vision) Aplastic crises (due to viral infection): episode of severe anemia Treatment There is no treatment. Folic acid supplementation is required to help the body with red blood cell production and improve symptoms of anemia. Prognosis Note that unlike the Hemoglobin S dsx (SS), pxts with Hemoglobin C dsx have a normal life expectancy, Before we forget, what about SC genotype? Please note the following: AA: normal pxts AS: don't show any symptoms SS: sickle cell disease (sicklers) AC: don't show any symptoms CC: described above SC? This condition is associated with recurrent anemia (breakdown of red cells in the blood vessels) and pain crises (vaso-occlusive crises). Some may also experience aseptic necrosis of the thigh bone (femur). Summary is that it is bad, One thing you must understand is that in terms of geographic distribution, the hemoglobin C allele is found at the highest frequencies in West Africa and it has been associated with protection against malaria. A good number of people have the C allele but are unaware of it. Also note that most people with the AC genotype show no symptoms, PLEASE NOTE THIS AND HELP SHARE WITH A FRIENd A man or woman with AS or AC or SS or SC or CC (very rare) cannot marry each other, if they want to avoid SS or SC. They must marry a partner with AA, if they don't want to born a child with Sickle call syndrome. If AS or AC marry each other, they have 25% chance of having a sickle child at every birth. If they marry SS or SC, they have 50% chance of having a sickle cell child at every birth. Please note all their kids could be AS AC or AA. If SS or SC marry each other, it's is nothing other than a terrible disaster. All their children will have Sickle cell SC and SS are almost the same only that SS suffers more severe crisis than SC carrier. You might not notice the presence of the disease on the body of SC carrier, unlike in SS. Solution The only thing that can change the genotype is an intentional act like BMT. Bone Marrow transplant technology has been proven to be the only permanent cure to SS SC and CC; however, it is new and very expensive. Naturally, environment or time cannot change genotype. Please Note: Divine Miracles can change it as well - it has happened in so many part of the world. Again, some SS carriers may start experiencing crisis at late age (as late as 40s). If these sets of people go for test in a quack lab, definitely the lab technician will assume AA or AS since the person is not having the symptom. Later in life it will become obvious when the symptom have come up, and another lab technician will report SS. Shared on twitter via @LAUMSA To all unmarried folks, please know your genotype and that of your spouse. Only people with AA genotype can marry people of other blood groups AC AS SC SS or CC without any medical complication. It is possible they are both your parents by assuming your mum is AC but was mistaken for AA. Your mum has to carry hemoglobin C, since you presumably inherit S from your dad. Since your brother is AA, and your sister is AS, this makes complete sense 1 Like |
Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by yungpowers(m): 10:32pm On Jun 26, 2015 |
My friend is asking for the meaning of the word child adoption.
Help please! |
Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by SaniSANOH(m): 10:55pm On Jun 26, 2015 |
Leem4: A friend of mine study genetic engineering he could have give us answer to ur inquiry but I couldn't reach him may be this image of Genotype and donor's can add to ur inquiry and any other person in need 1 Like
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Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by Henrypraise: 11:02pm On Jun 26, 2015 |
My friend n his wife av dis same issue, husband is AS, wife is AA, daughter is SS, at least dats d report de told me de had from abt 4 hospital. Just dis evenin, I was in a conversation wit a lady hu said her daughters crisis started wen she started menstruation n so many hospital diagnosed d daughter SS whereas she is AA n her husband AA, she struggled wit d crisis on n off till abt sum years ago wen de were referred to Oghara teachinh hospital in delta state n it was discovered d girl was not SS but lacked d white blood cells, neccessary tins were don n kip doin n d daughter is still very healthy 5years n countin, she will be bak from service soonest accordin to d mom. Don't listen to pple sayin stuff abt u bein adopted pls, ur parents ar already passin tru a lot don't make dem feel worse. Only pray 4 healin n be a gud daughter. |
Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by pbs4real(m): 11:15pm On Jun 26, 2015 |
Draify pls would you help us shed more light on this issue. . . .tnx |
Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by abiola708(m): 11:20pm On Jun 26, 2015 |
cahnellven:can . an sc patient go into diving |
Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by NobleG1(m): 11:22pm On Jun 26, 2015 |
[size=14pt]Genotype effect on marraige[/size]. If AA marries AA = AA babies If AA marries AS = AA and AS babies If AA marries SS = AA, AS and SS babies If AS marries AS = AA, AS and SS babies If AS marries SS = AS and SS babies If SS marries SS = SS babies |
Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by ejihand1(m): 11:22pm On Jun 26, 2015 |
pekelepekele:Hahahaha. This is science my dear. Is either the mistake is from the diagnostic centre or something. Anyway, you could make a good comedian. Thanks for making me laf for a long while now |
Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by donefezy: 11:27pm On Jun 26, 2015 |
Malawian:i taught as much..plz don't use ur secondary school knowledge on this |
Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by aimeeworship: 11:39pm On Jun 26, 2015 |
aimeeworship: |
Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by zanga420: 11:47pm On Jun 26, 2015 |
Leem4:Abeg, ppl should take it easy in pointing accussing fingers to the woman which compounds her pains. Guess ur mum is AC not AA while dad is As, thats the likely scenario the makes u SC, worst still its a mutation. #bestrong 1 Like |
Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by zanga420: 11:49pm On Jun 26, 2015 |
bukhety:logical n possible 1 Like |
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