sainty2k3:
YES it is not impossible, couples that are AA/AS can give birth to SS , this is how
1. let me differentiate between haemoglobin genotype and haemoglobin phenotype
To get a particular GENOTYPE you have to do a genetic testing or use two or more of the screening test (the conventional electrophoresis that we do + HPLC or other similar test) to confirm the true genotype while hb PHENOTYPE is the appearance /characteristics of an individual haemoglobin on conventional electrophoresis which we loosely refer to as GENOTYPE
Most times when we call ourselves AA,SS,AS we are actually referring to our Haemoglogin PHENOTYPE and NOT GENOTYPE, as most of us don’t do genetic tests, all we do is haemoglobin electrophoresis
2. lets explain the concept of thalasemic trait. Thalassemias are quantitative defect of haemoglobin which means some one can be AA but the one or both A in this person is is absent otherwise known as thalassemia minor and major respectively. If such person run haemoglobin Electrophoresis( the test that we always loosely regard to as genotype) only A band will be seen and such a person will be regarded as AA. But they are also prone to anaemias and some certain abnormal features in the blood depending on the degree in the reduction in the defective A . such individuals can be Aβ-Thalassaemia(otherwise known as thalassaemic trait) if one of the’ A gene’ is normal, or β-Thalassaemia major if both are affected
3. lets merge the two concepts above and form AND SEE THE DIFFERENT PHENOTYPE THAT EXIST AND THE POSSIBLE CORRESPONDING GENOTYPE
If PHENOTYPE is AA the likely GENOTYPES will be AA , Aβ-Thalassaemia
If PHENOTYPE is SS the likely GENOTYPES will be SS, Sβ-Thalassaemia (MEANING THE OTHER ‘A’ THAT WOULD HAVE MADE THIS AN ‘AS’ IS TOTALLY ABSENT) Others might include SD,SG etc though these are very rare
If PHENOTYPE is AS the likely GENOTYPES will be SA (NOTE – ‘S’ COMES BEFORE ‘A’ BECAUSE THE A IS THALASSAEMIC, THOUGH NOT TOTALLY ABSENT AS THE ONE ABOVE ,IT IS SUSBSTANTIALLY REDUCE), or truely AS
4. Lets assume this our hypothetical couple have Hb eleterophoresis done and was told that the genotype of partner 1 is AA, and that of partner 2 is AS ,but the one that is called AA is actually Aβ-Thalassaemia as ealier mentioned. There possible offspring include
I. AA, If the child inherit the normal A from partner 1 and another normal A from partner 2
II. Aβ-Thalassaemia ,If the child inherit β-Thalassaemic A from the partner 1 and normal A from partner 2
III. AS,If the child inherit normal A from partner 1 and S from patner 2
IV. Sβ-Thalassaemia If the child inherit β-Thalassaemic A from partner 1 and S from partner 2
Note that scenario I above will show AA on Hb electrophoresis, scenario ii will show AA on electrophoresis, scenario iii will show AS on electrophoresis and scenario iv will show SS on electrophoresis
I have tried to simplify the medical terms but if you still have a doubt or clarification ask and I will try to shed more light, as much as I can.

Pls stop misleading the public with false information, thank you.

ChelseaDr:
Op thanks for this because a lot of people may not know this.

It is also important to note that although Sβ-Thalasaemia and Hb SS are both forms of Sickle cell disease, they are completely two different disease conditions with far-reaching impact on the person suffering from them.

While Hb SS is as a result of defect in the quality of haemoglobin, Sβ-thalasaemia is as a result of the quantity of haemoglobins present and to diagnose this one needs quantitative analysis of the haemoglobin chains whereas qualitative analysis is enough to diagnose SS which electrophoresis does.

Again, thank you.
Cheers!!

OP is misleading the public with false information and you are supporting it.....why?

You just quoted only one study and the study you quoted actually collaborates with what fitnessdoctor said, it doesnt say AA and AS can give birth to SS as you claim.
Please stop misinforming people, always show refrences and more than one please.

sainty2k3:

If I quote my references I doubt if many will be able to riglt comprehend them.
But I found this
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459467/#!po=8.82353

@OP stop coming to lie here, stop copying and pasting thoughtless and unproven hypothesis from one inane school of thought. you all know nothing and will only confuse yourselves and those that don't know.
to simplify this for you and every other layperson, assuming parent 1 is AA and parent 2 is AS, it means that parent 1 will give either of the A's they have in their blood while parent 2 will give either the A or the S part at fertilisation. but these are passed on at random and so it is clearly one thing that you have no control over - parent 1 only has an A part to give while parent 2 cannot decide on whether to give out the A part or the S part - reason again is that they are passe on at random, but the worst that will ever come to them is an AS child.


On a lighter note though, it is true that an AA man and an AS woman can have an SS child but of course only if she did cheat with either an AS or an SS man!

Thrash! Attention seeking!

sainty2k3:

If I quote my references I doubt if many will be able to riglt comprehend them.
But I found this
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459467/#!po=8.82353

op u do not understand the journal at al. besides, the journal there are more information in postgraduate haematology textbook.if you an haematogist or resident in haematology you will know the book. in some, there could be disorder of hemoglobin structure and number which could produce sickle cell and thalassemias respectively. thalassemias is a bad disorder because one or more hemoglobin chains are missing. it is not possible with aa and as to produce ss.pls do not create confusion people. thanks.

Op, let me help me simplify it

In summary, it is not possible under correct diagnosis for AA and AS to produce SS

except

AA was misdiagnosed, meaning he is actually AS but was misdiagnosed as AA.

---

Dont come here and be telling us 1+1=1
Na lie. 1+1=2

funmisticqueen:
You just quoted only one study and the study you quoted actually collaborates with what fitnessdoctor said, it doesnt say AA and AS can give birth to SS as you claim.
Please stop misinforming people, always show refrences and more than one please.

Please research more on it rather than discarding a fact Sbeta thalassemia are often misdiagnosed as SS and Abeta thallasemia are often misdiagnosed as AA on electrophoresis, google scholar is your friend,

sainty2k3:

https://www.google.com.ng/amp/www.graphic.com.gh/news/health/aa-and-as-partners-produce-ss-baby-is-that-possible.amp.html

One of them is not faithful simple and short. Apart from ABO group which has dominant and hiding gene, haemoglobin genenotype doesn't have dominant and hiding gene. Thanks. Pls u can't convince me.

dreshemokha:
Op. Genetics and health is not mathematics as you just calculated.
And yes it is totally IMPOSSIBLE, a marriage between AA and AS can NEVER produce SS.
Moreover, there is no relationship in inheritance between sickle cell diseases and thalassemias.


Am a doctor with a health blog. Check my signature and visit my blog for robust health info and publications.

I agree with you doc. It is IMPOSSIBLE for AA and AS to have an SS child. I'm a nurse and biologist and It is very impossible.

If you tried, you didnt suceed, even i had a hard time comprehending it, i had to read it twice to get it which was strange for me.

sainty2k3:

Thanks for that , I tried to break it down to layman's level, ,its obvious some will still not get it

joyandfaith:


op u do not understand the journal at al. besides, the journal there are more information in postgraduate haematology textbook.if you an haematogist or resident in haematology you will know the book. in some, there could be disorder of hemoglobin structure and number which could produce sickle cell and thalassemias respectively. thalassemias is a bad disorder because one or more hemoglobin chains are missing. it is not possible with aa and as to produce ss.pls do not create confusion people. thanks.

You didn't read my post and that is obvious unless you do genetic testing or combine other tests like HPLC with HB electrophoresis you might be misdiagnosing beta thalassemia, and yes inheritance of beta thalassemia can co exist with that of sickle cell as S beta thallasemia genotypically which the HB electrophoresis will still show as 'SS' thought its actually Sbeta thalassemia

funmisticqueen:
You just quoted only one study and the study you quoted actually collaborates with what fitnessdoctor said, it doesnt say AA and AS can give birth to SS as you claim.
Please stop misinforming people, always show refrences and more than one please.

op and many here could not understand import of the journal. op is dangerous. hope he is not a doctor sir. if he is mls, I can only pray for people that he would meet. if he is a nurse, no problem, we are still save. if he's not any of above health worker ,ur sin of misinformation is forgiven.

oviejnr:
The only reason where AA can marry AS and give birth to SS is when the child doesn't belong to the man. You don't need a DNA to find out, send that hoe outta your house

So many funny comments on this thread

See as guys dey para for the OP

We want instances where AA+AS=SS.....me wey dey think say I have made it in life with my AA genotype.... Chai @op...e no good ooo

funmisticqueen:
If you tried, you didnt suceed, even i had a hard time comprehending it, i had to read it twice to get it which was strange for me.

Yea difficult, bit I'm happy I tried, I hope someone with deep knowledge of this will simplify it further

dreshemokha:
Op. Genetics and health is not mathematics as you just calculated.
And yes it is totally IMPOSSIBLE, a marriage between AA and AS can NEVER produce SS.
Moreover, there is no relationship in inheritance between sickle cell diseases and thalassemias.


Am a doctor with a health blog. Check my signature and visit my blog for robust health info and publications.

Thank u.
I wonder what the OP could be smoking.

NwaAmaikpe:


Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS'

Of course it is possible.

That 'AA' is married to an 'AS' does not mean that
the 'AS' can not shag another 'AS' on the side and bring in a bastard 'SS'

---

Please don't believe this nonsense... Very soon, one confused scientist will bring up a theory claiming it is possible for paternity tests to come back negative when you are truly the father.

I will find you and give you a bottle of origin!

He cant, he only quoted a news article

Scholar212:
OP can you cite any medical journal to buttress your claim, in all my haematology classes and even deep lectures on blood grouping, genotype and haemoglobinopathies I have never come across such not online, textbook or lecture. The burden of prove now lies on you to justify your claim of co-dominant thalasemia trait and HB genotype

sainty2k3:
YES it is not impossible, couples that are AA/AS can give birth to SS , this is how
1. let me differentiate between haemoglobin genotype and haemoglobin phenotype
To get a particular GENOTYPE you have to do a genetic testing or use two or more of the screening test (the conventional electrophoresis that we do + HPLC or other similar test) to confirm the true genotype while hb PHENOTYPE is the appearance /characteristics of an individual haemoglobin on conventional electrophoresis which we loosely refer to as GENOTYPE
Most times when we call ourselves AA,SS,AS we are actually referring to our Haemoglogin PHENOTYPE and NOT GENOTYPE, as most of us don’t do genetic tests, all we do is haemoglobin electrophoresis
2. lets explain the concept of thalasemic trait. Thalassemias are quantitative defect of haemoglobin which means some one can be AA but the one or both A in this person is is absent otherwise known as thalassemia minor and major respectively. If such person run haemoglobin Electrophoresis( the test that we always loosely regard to as genotype) only A band will be seen and such a person will be regarded as AA. But they are also prone to anaemias and some certain abnormal features in the blood depending on the degree in the reduction in the defective A . such individuals can be Aβ-Thalassaemia(otherwise known as thalassaemic trait) if one of the’ A gene’ is normal, or β-Thalassaemia major if both are affected
3. lets merge the two concepts above and form AND SEE THE DIFFERENT PHENOTYPE THAT EXIST AND THE POSSIBLE CORRESPONDING GENOTYPE
If PHENOTYPE is AA the likely GENOTYPES will be AA , Aβ-Thalassaemia
If PHENOTYPE is SS the likely GENOTYPES will be SS, Sβ-Thalassaemia (MEANING THE OTHER ‘A’ THAT WOULD HAVE MADE THIS AN ‘AS’ IS TOTALLY ABSENT) Others might include SD,SG etc though these are very rare
If PHENOTYPE is AS the likely GENOTYPES will be SA (NOTE – ‘S’ COMES BEFORE ‘A’ BECAUSE THE A IS THALASSAEMIC, THOUGH NOT TOTALLY ABSENT AS THE ONE ABOVE ,IT IS SUSBSTANTIALLY REDUCE), or truely AS
4. Lets assume this our hypothetical couple have Hb eleterophoresis done and was told that the genotype of partner 1 is AA, and that of partner 2 is AS ,but the one that is called AA is actually Aβ-Thalassaemia as ealier mentioned. There possible offspring include
I. AA, If the child inherit the normal A from partner 1 and another normal A from partner 2
II. Aβ-Thalassaemia ,If the child inherit β-Thalassaemic A from the partner 1 and normal A from partner 2
III. AS,If the child inherit normal A from partner 1 and S from patner 2
IV. Sβ-Thalassaemia If the child inherit β-Thalassaemic A from partner 1 and S from partner 2
Note that scenario I above will show AA on Hb electrophoresis, scenario ii will show AA on electrophoresis, scenario iii will show AS on electrophoresis and scenario iv will show SS on electrophoresis
I have tried to simplify the medical terms but if you still have a doubt or clarification ask and I will try to shed more light, as much as I can.

Classic Sickle cell disease denoted by AS and SS are different and must be differentiated from Thalassemia major and minor.
Sickle cell:
1. Mostly among African and African American
2. Genetic abnormality is substitution of glutamic acid for valine at the 6th beta position
3. Clinical presentations maybe similar, but doesn't have the variations of Thalassamia

Thalassamia:
1. Mostly among people of Mediterranean descent
2. Genetic substitution of glutamic acid for lysine, not valine as in SCD
3. Wide clinic presentations from the instantly fatal absence of both alpha and beta chains of hemoglobin, to mild abnormality of the beta chain at the same 6th position.

This understanding is importance for both medical lab technologists who perform these tests, the nurses who counsel the patients, and the physician in charge of diagnosing and managing these conditions.
They don't test the same on electrophoresis, because their amino acid components are not similar, therefore if your lab has been identifyoing thalassamia in terms of AS, SS, then that is wrong

1StopRudeness:
Yeye genetic probability calculations/posibilities....even If all ur village witch get time reason ur matter....AA & AS can't give SS...

It can never happen...make no woman try this yeye with me oooo...me na confirm AA...if I marry any AS babe wey wan come pull this SS stunt genetic calculation use explain herself out of infidelity.....just dey go ur papa house..no need to explain this nonsense genetics to me

So you go chase am comot?

joyandfaith:


op and many here could not understand import of the journal. op is dangerous. hope he is not a doctor sir. if he is mls, I can only pray for people that he would meet. if he is a nurse, no problem, we are still save. if he's not any of above health worker ,ur sin of misinformation is forgiven.

I'm a doctor and an authority in the field of knowledge I shared, you find it difficult to understand ,Yes,but those are facts u can verify

NwaAmaikpe:


Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS'

Of course it is possible.

That 'AA' is married to an 'AS' does not mean that
the 'AS' can not shag another 'AS' on the side and bring in a bastard 'SS'

---

Please don't believe this nonsense... Very soon, one confused scientist will bring up a theory claiming it is possible for paternity tests to come back negative when you are truly the father.

first time you ll make sense in a long while

nelszx:


Quite educative

so u understand all those things they wrote?

Nobody with knowledge has actually agrees with your theory

sainty2k3:

Yea difficult, bit I'm happy I tried, I hope someone with deep knowledge of this will simplify it further

Nobody with knowledge has actually agreed with your theory not to talk of simplifying it

sainty2k3:

Yea difficult, bit I'm happy I tried, I hope someone with deep knowledge of this will simplify it further

naijaking1:


Classic Sickle cell disease denoted by AS and SS are different and must be differentiated from Thalassemia major and minor.
Sickle cell:
1. Mostly among African and African American
2. Genetic abnormality is substitution of glutamic acid for valine at the 6th beta position
3. Clinical presentations maybe similar, but doesn't have the variations of Thalassamia

Thalassamia:
1. Mostly among people of Mediterranean descent
2. Genetic substitution of glutamic acid for lysine, not valine as in SCD
3. Wide clinic presentations from the instantly fatal absence of both alpha and beta chains of hemoglobin, to mild abnormality of the beta chain at the same 6th position.

This understanding is importance for both medical lab technologists who perform these tests, the nurses who counsel the patients, and the physician in charge of diagnosing and managing these conditions.
They don't test the same on electrophoresis, because their amino acid components are not similar, therefore if your lab has been identifyoing thalassamia in terms of AS, SS, then that is wrong

You probably will not get it wrong of you do HPLC with HB electrophoresis or your electrophoresis can also quantify, but if not genotype Sbeta thal . will have an S only band on electrophoresis while A beta thal will have an A only band on electrophoresis which can be misinterpreted as SS and AA respectively

from your link

Sickling-negative” people having SS babies; “AA” and “AS” couple producing “SS” babies. Are these possible? The correct answer is “NO!”

dreshemokha:
Op. Genetics and health is not mathematics as you just calculated.
And yes it is totally IMPOSSIBLE, a marriage between AA and AS can NEVER produce SS.
Moreover, there is no relationship in inheritance between sickle cell diseases and thalassemias.


Am a doctor with a health blog. Check my signature and visit my blog for robust health info and publications.

being a doctor doesn't mean u know everything pls go and update ur knowledge of hemoglobin defects or simply visit sickle cell center in igbobi Lagos.
and yes it is very very possible for a AA and AS couple to give birth to a sickler though not the SS sickler (but electrophoresis will read the genotype as SS)
a lot of doctors/ medical personnel don't know this

Mods please kindly take down this thread, it is total rubbish, completely false and misleading. It is baseless and unscientific. Medical science is not mathematics, op is probably a mathematician. I think op is just being mischievous.

Lalasticlala pls.

sainty2k3:

You didn't read my post and that is obvious unless you do genetic testing or combine other tests like HPLC with HB electrophoresis you might be misdiagnosing beta thalassemia, and yes inheritance of beta thalassemia can co exist with that of sickle cell as S beta thallasemia genotypically which the HB electrophoresis will still show as 'SS' thought its actually Sbeta thalassemia

ur post, heading and explanation are misleading. see what you posted ' Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' and give birth to SS'.
I repeat you are misleading public. accept this and apologize. in haemoglobinopathies, diagnosis is molecular ss is a diagnosis, as is another diagnosis. s beta thal is also diagnosis. if you say misdiagnosis, I can tell u clinically there are subtle difference between s beta thal and ss. that is why input of haematogist is very important to avoid misdiagnosis.

S2kluv:
from your link

Sickling-negative” people having SS babies; “AA” and “AS” couple producing “SS” babies. Are these possible? The correct answer is “NO!”

yes
pls go and read about thalessemia
u can use google