| Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by lexy2014: 10:37pm On Jul 15, 2017 |
sainty2k3:
YES it is not impossible, couples that are AA/AS can give birth to SS , this is how
1. let me differentiate between haemoglobin genotype and haemoglobin phenotype
To get a particular GENOTYPE you have to do a genetic testing or use two or more of the screening test (the conventional electrophoresis that we do + HPLC or other similar test) to confirm the true genotype while hb PHENOTYPE is the appearance /characteristics of an individual haemoglobin on conventional electrophoresis which we loosely refer to as GENOTYPE
Most times when we call ourselves AA,SS,AS we are actually referring to our Haemoglogin PHENOTYPE and NOT GENOTYPE, as most of us don’t do genetic tests, all we do is haemoglobin electrophoresis
2. lets explain the concept of thalasemic trait. Thalassemias are quantitative defect of haemoglobin which means some one can be AA but the one or both A in this person is is absent otherwise known as thalassemia minor and major respectively. If such person run haemoglobin Electrophoresis( the test that we always loosely regard to as genotype) only A band will be seen and such a person will be regarded as AA. But they are also prone to anaemias and some certain abnormal features in the blood depending on the degree in the reduction in the defective A . such individuals can be Aβ-Thalassaemia(otherwise known as thalassaemic trait) if one of the’ A gene’ is normal, or β-Thalassaemia major if both are affected
3. lets merge the two concepts above and form AND SEE THE DIFFERENT PHENOTYPE THAT EXIST AND THE POSSIBLE CORRESPONDING GENOTYPE
If PHENOTYPE is AA the likely GENOTYPES will be AA , Aβ-Thalassaemia
If PHENOTYPE is SS the likely GENOTYPES will be SS, Sβ-Thalassaemia (MEANING THE OTHER ‘A’ THAT WOULD HAVE MADE THIS AN ‘AS’ IS TOTALLY ABSENT) Others might include SD,SG etc though these are very rare
If PHENOTYPE is AS the likely GENOTYPES will be SA (NOTE – ‘S’ COMES BEFORE ‘A’ BECAUSE THE A IS THALASSAEMIC, THOUGH NOT TOTALLY ABSENT AS THE ONE ABOVE ,IT IS SUSBSTANTIALLY REDUCE), or truely AS
4. Lets assume this our hypothetical couple have Hb eleterophoresis done and was told that the genotype of partner 1 is AA, and that of partner 2 is AS ,but the one that is called AA is actually Aβ-Thalassaemia as ealier mentioned. There possible offspring include
I. AA, If the child inherit the normal A from partner 1 and another normal A from partner 2
II. Aβ-Thalassaemia ,If the child inherit β-Thalassaemic A from the partner 1 and normal A from partner 2
III. AS,If the child inherit normal A from partner 1 and S from patner 2
IV. Sβ-Thalassaemia If the child inherit β-Thalassaemic A from partner 1 and S from partner 2
Note that scenario I above will show AA on Hb electrophoresis, scenario ii will show AA on electrophoresis, scenario iii will show AS on electrophoresis and scenario iv will show SS on electrophoresis
I have tried to simplify the medical terms but if you still have a doubt or clarification ask and I will try to shed more light, as much as I can.
after this expert analysis what is ur expert advice 4 intending married couples and married couples who are still in d baby factory?by d way, is this d findings of ur personal research or d product of what u saw in a dream? 1 Like |
| Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by IYANGBALI: 10:37pm On Jul 15, 2017 |
Licensed to cheat |
| Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by femi4: 10:37pm On Jul 15, 2017 |
sainty2k3:
YES it is not impossible, couples that are AA/AS can give birth to SS , this is how
1. let me differentiate between haemoglobin genotype and haemoglobin phenotype
To get a particular GENOTYPE you have to do a genetic testing or use two or more of the screening test (the conventional electrophoresis that we do + HPLC or other similar test) to confirm the true genotype while hb PHENOTYPE is the appearance /characteristics of an individual haemoglobin on conventional electrophoresis which we loosely refer to as GENOTYPE
Most times when we call ourselves AA,SS,AS we are actually referring to our Haemoglogin PHENOTYPE and NOT GENOTYPE, as most of us don’t do genetic tests, all we do is haemoglobin electrophoresis
2. lets explain the concept of thalasemic trait. Thalassemias are quantitative defect of haemoglobin which means some one can be AA but the one or both A in this person is is absent otherwise known as thalassemia minor and major respectively. If such person run haemoglobin Electrophoresis( the test that we always loosely regard to as genotype) only A band will be seen and such a person will be regarded as AA. But they are also prone to anaemias and some certain abnormal features in the blood depending on the degree in the reduction in the defective A . such individuals can be Aβ-Thalassaemia(otherwise known as thalassaemic trait) if one of the’ A gene’ is normal, or β-Thalassaemia major if both are affected
3. lets merge the two concepts above and form AND SEE THE DIFFERENT PHENOTYPE THAT EXIST AND THE POSSIBLE CORRESPONDING GENOTYPE
If PHENOTYPE is AA the likely GENOTYPES will be AA , Aβ-Thalassaemia
If PHENOTYPE is SS the likely GENOTYPES will be SS, Sβ-Thalassaemia (MEANING THE OTHER ‘A’ THAT WOULD HAVE MADE THIS AN ‘AS’ IS TOTALLY ABSENT) Others might include SD,SG etc though these are very rare
If PHENOTYPE is AS the likely GENOTYPES will be SA (NOTE – ‘S’ COMES BEFORE ‘A’ BECAUSE THE A IS THALASSAEMIC, THOUGH NOT TOTALLY ABSENT AS THE ONE ABOVE ,IT IS SUSBSTANTIALLY REDUCE), or truely AS
4. Lets assume this our hypothetical couple have Hb eleterophoresis done and was told that the genotype of partner 1 is AA, and that of partner 2 is AS ,but the one that is called AA is actually Aβ-Thalassaemia as ealier mentioned. There possible offspring include
I. AA, If the child inherit the normal A from partner 1 and another normal A from partner 2
II. Aβ-Thalassaemia ,If the child inherit β-Thalassaemic A from the partner 1 and normal A from partner 2
III. AS,If the child inherit normal A from partner 1 and S from patner 2
IV. Sβ-Thalassaemia If the child inherit β-Thalassaemic A from partner 1 and S from partner 2
Note that scenario I above will show AA on Hb electrophoresis, scenario ii will show AA on electrophoresis, scenario iii will show AS on electrophoresis and scenario iv will show SS on electrophoresis
I have tried to simplify the medical terms but if you still have a doubt or clarification ask and I will try to shed more light, as much as I can.
Olodo rabata Na your type dey collect extra sheet for exam and still score F at the end of the day, continue to write rubbish with confidence 2 Likes |
| Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by sainty2k3(m): 10:37pm On Jul 15, 2017 |
jnrremedy:
being a doctor doesn't mean u know everything pls go and update ur knowledge of hemoglobin defects or simply visit sickle cell center in igbobi Lagos.
and yes it is very very possible for a AA and AS couple to give birth to a sickler though not the SS sickler (but electrophoresis will read the genotype as SS)
a lot of doctors/ medical personnel don't know this Thank God people like you are here, many are publicly displaying ignorance, they also ignored our parlance of 'never say never'. I know I wasn't perfect in describing it in layman's language, but very sure of the info 1 Like |
| Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by Nobody: 10:37pm On Jul 15, 2017 |
Paternity tests are not 100% foolproof, there is a margin for error, just like condom NwaAmaikpe:
Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS'
Of course it is possible.
That 'AA' is married to an 'AS' does not mean that
the 'AS' can not shag another 'AS' on the side and bring in a bastard 'SS'
Please don't believe this nonsense... Very soon, one confused scientist will bring up a theory claiming it is possible for paternity tests to come back negative when you are truly the father.
|
| Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by tosyne2much(m): 10:38pm On Jul 15, 2017 |
darlenese:
nonsense and ingredient.
no AS and AA has ever given birth to an SS. carry your rubbish theory and gerrahere.
mshweeeeeeew. LMAO  |
| Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by Nobody: 10:39pm On Jul 15, 2017 |
tosyne2much:
So you go chase am comot? You still dey ask..?? Na to chase am go her papa house sure pass |
| Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by Kam0007: 10:40pm On Jul 15, 2017 |
sainty2k3:
Yea difficult, bit I'm happy I tried, I hope someone with deep knowledge of this will simplify it further @OP nothing wey you sabi. go side abeg! |
| Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by stevecantrell: 10:41pm On Jul 15, 2017 |
tosyne2much:
So many funny comments on this thread
See as guys dey para for the OP its not funny its 100% scientific fact. If youre getting married know your genotype, it might save you the cost of a DNA test in future. 1 Like |
| Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by sainty2k3(m): 10:41pm On Jul 15, 2017 |
lexy2014:
after this expert analysis what is ur expert advice 4 intending married couples and married who are still in d baby factory? Thank you, to be really sure of the genotype, you need to do genetic studies, but since that's not widely available, You can do both HB electrophoresis and High performance Liquid Chromatography (HPLC) these two we help in proper interpretation |
| Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by lisbonabdulahi: 10:41pm On Jul 15, 2017 |
sainty2k3:
YES it is not impossible, couples that are AA/AS can give birth to SS , this is how
1. let me differentiate between haemoglobin genotype and haemoglobin phenotype
To get a particular GENOTYPE you have to do a genetic testing or use two or more of the screening test (the conventional electrophoresis that we do + HPLC or other similar test) to confirm the true genotype while hb PHENOTYPE is the appearance /characteristics of an individual haemoglobin on conventional electrophoresis which we loosely refer to as GENOTYPE
Most times when we call ourselves AA,SS,AS we are actually referring to our Haemoglogin PHENOTYPE and NOT GENOTYPE, as most of us don’t do genetic tests, all we do is haemoglobin electrophoresis
2. lets explain the concept of thalasemic trait. Thalassemias are quantitative defect of haemoglobin which means some one can be AA but the one or both A in this person is is absent otherwise known as thalassemia minor and major respectively. If such person run haemoglobin Electrophoresis( the test that we always loosely regard to as genotype) only A band will be seen and such a person will be regarded as AA. But they are also prone to anaemias and some certain abnormal features in the blood depending on the degree in the reduction in the defective A . such individuals can be Aβ-Thalassaemia(otherwise known as thalassaemic trait) if one of the’ A gene’ is normal, or β-Thalassaemia major if both are affected
3. lets merge the two concepts above and form AND SEE THE DIFFERENT PHENOTYPE THAT EXIST AND THE POSSIBLE CORRESPONDING GENOTYPE
If PHENOTYPE is AA the likely GENOTYPES will be AA , Aβ-Thalassaemia
If PHENOTYPE is SS the likely GENOTYPES will be SS, Sβ-Thalassaemia (MEANING THE OTHER ‘A’ THAT WOULD HAVE MADE THIS AN ‘AS’ IS TOTALLY ABSENT) Others might include SD,SG etc though these are very rare
If PHENOTYPE is AS the likely GENOTYPES will be SA (NOTE – ‘S’ COMES BEFORE ‘A’ BECAUSE THE A IS THALASSAEMIC, THOUGH NOT TOTALLY ABSENT AS THE ONE ABOVE ,IT IS SUSBSTANTIALLY REDUCE), or truely AS
4. Lets assume this our hypothetical couple have Hb eleterophoresis done and was told that the genotype of partner 1 is AA, and that of partner 2 is AS ,but the one that is called AA is actually Aβ-Thalassaemia as ealier mentioned. There possible offspring include
I. AA, If the child inherit the normal A from partner 1 and another normal A from partner 2
II. Aβ-Thalassaemia ,If the child inherit β-Thalassaemic A from the partner 1 and normal A from partner 2
III. AS,If the child inherit normal A from partner 1 and S from patner 2
IV. Sβ-Thalassaemia If the child inherit β-Thalassaemic A from partner 1 and S from partner 2
Note that scenario I above will show AA on Hb electrophoresis, scenario ii will show AA on electrophoresis, scenario iii will show AS on electrophoresis and scenario iv will show SS on electrophoresis
I have tried to simplify the medical terms but if you still have a doubt or clarification ask and I will try to shed more light, as much as I can.
what is the chance of this happening, and when last did we see one |
| Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by jnrremedy(m): 10:41pm On Jul 15, 2017 |
joyandfaith:
ur post, heading and explanation are misleading. see what you posted ' Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' and give birth to SS'.
I repeat you are misleading public. accept this and apologize. in haemoglobinopathies, diagnosis is molecular ss is a diagnosis, as is another diagnosis. s beta thal is also diagnosis. if you say misdiagnosis, I can tell u clinically there are subtle difference between s beta thal and ss. that is why input of haematogist is very important to avoid misdiagnosis. the common gel electrophoresis will read SS for a S beta thalessemia will u call that a misdiagnosis also bear in more mind that clinical manifestation of beta thalessemia is similar to sickle cell disease though they re different conditions |
| Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by sgtponzihater1(m): 10:41pm On Jul 15, 2017 |
I did a post on Nigerian doctors days ago, and for some sad reason, it was deleted and I was banned for 24hrs. Nigerian doctors can't see an unfamiliar topic and discuss at an academic level on it, they despise the unfamiliar and are quick to point out quackery. The OP have brought up an academic and post graduate level argument, which while possible invitro, is left with very few example invivo. Mutation as a phenomenon is however valid. Once again well done OP 7 Likes |
| Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by joyandfaith: 10:42pm On Jul 15, 2017 |
jnrremedy:
being a doctor doesn't mean u know everything pls go and update ur knowledge of hemoglobin defects or simply visit sickle cell center in igbobi Lagos.
and yes it is very very possible for a AA and AS couple to give birth to a sickler though not the SS sickler (but electrophoresis will read the genotype as SS)
a lot of doctors/ medical personnel don't know this that is misdiagnosis. I repeat with good clinical history the misdiagnosis can be avoided in clinical practice. the heading is misleading. the heading could have been , "Medical laboratories in Nigeria can misdiagnose AA or AS as SS'' 3 Likes |
| Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by Nobody: 10:43pm On Jul 15, 2017 |
I have research on it, but you seem to be contradicting yourself, you are yet to show me SCIENTIFIC SOURCES supporting your claim. This is not evidence based and you are still stubbornly supporting something you can't even explain clearly. sainty2k3:
Please research more on it rather than discarding a fact Sbeta thalassemia are often misdiagnosed as SS and Abeta thallasemia are often misdiagnosed as AA on electrophoresis, google scholar is your friend, |
| Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by oviejnr(m): 10:44pm On Jul 15, 2017 |
tosyne2much:
So many funny comments on this thread
See as guys dey para for the OP Bro Na true Na. Op just wan brainwash us. |
| Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by logica(m): 10:44pm On Jul 15, 2017 |
http://glowville.net/what-you-must-know-about-genotype-and-blood-group-compatibility/What is the Genotype and Blood Group compatibility that is good for marriage?
Study this table below carefully:
AA + AA = AA, AA, AA, AA
AA + AS = AA, AS, AA, AS
AA + SS = AS, AS, AS, AS
AA + AC = AA, AA, AA, AC
AS + AS = AA, AS, AS, SS
AS + SS = AS, SS, SS, SS
AS + AC = AA, AC, AS,SS
SS + SS = SS, SS, SS, SS
AC + SS = AS, AS, SC, SC
AC + AC = AA, AC, AC, CC
Based on the table above, you can see that a person with the genotype AA can marry across. There’s no risk of having a sicklier for a child even when he or she marries an SS. An AA genotype person marrying an SS can only result in AS children. There’s no hope of having a child with the genotype AA. But there’s no danger either.
Someone with the genotype AS should only marry someone with the genotype AA because if AS marries another AS there’s one out of 4 chances (AS, AS, AA and SS) that they will have a child with the sickle-cell disease. Same applies when AC is combined. AC and AS combine will produce AA, AS, AC, SC, the sickle-cell disease will be SC.
Of course there are many cases where two abnormal was combined that is an AS and AS or AC and AC or AC and AS couples and had up to five or six children without a single sicklier among them. But there is no need to risk it? What if you’re not so lucky? Can you forgive yourself when you end up having a child with the sickle-cell disease and put the child through the agony the disease brings when you could have easily avoided it by doing a genotype and blood group compatibility test. |
| Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by tosyne2much(m): 10:44pm On Jul 15, 2017 |
1StopRudeness:
You still dey ask..?? Na to chase am go her papa house sure pass Egbon you no get mercy at all ooo |
| Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by Nobody: 10:44pm On Jul 15, 2017 |
sainty2k3:
YES it is not impossible, couples that are AA/AS can give birth to SS , this is how
1. let me differentiate between haemoglobin genotype and haemoglobin phenotype
To get a particular GENOTYPE you have to do a genetic testing or use two or more of the screening test (the conventional electrophoresis that we do + HPLC or other similar test) to confirm the true genotype while hb PHENOTYPE is the appearance /characteristics of an individual haemoglobin on conventional electrophoresis which we loosely refer to as GENOTYPE
Most times when we call ourselves AA,SS,AS we are actually referring to our Haemoglogin PHENOTYPE and NOT GENOTYPE, as most of us don’t do genetic tests, all we do is haemoglobin electrophoresis
2. lets explain the concept of thalasemic trait. Thalassemias are quantitative defect of haemoglobin which means some one can be AA but the one or both A in this person is is absent otherwise known as thalassemia minor and major respectively. If such person run haemoglobin Electrophoresis( the test that we always loosely regard to as genotype) only A band will be seen and such a person will be regarded as AA. But they are also prone to anaemias and some certain abnormal features in the blood depending on the degree in the reduction in the defective A . such individuals can be Aβ-Thalassaemia(otherwise known as thalassaemic trait) if one of the’ A gene’ is normal, or β-Thalassaemia major if both are affected
3. lets merge the two concepts above and form AND SEE THE DIFFERENT PHENOTYPE THAT EXIST AND THE POSSIBLE CORRESPONDING GENOTYPE
If PHENOTYPE is AA the likely GENOTYPES will be AA , Aβ-Thalassaemia
If PHENOTYPE is SS the likely GENOTYPES will be SS, Sβ-Thalassaemia (MEANING THE OTHER ‘A’ THAT WOULD HAVE MADE THIS AN ‘AS’ IS TOTALLY ABSENT) Others might include SD,SG etc though these are very rare
If PHENOTYPE is AS the likely GENOTYPES will be SA (NOTE – ‘S’ COMES BEFORE ‘A’ BECAUSE THE A IS THALASSAEMIC, THOUGH NOT TOTALLY ABSENT AS THE ONE ABOVE ,IT IS SUSBSTANTIALLY REDUCE), or truely AS
4. Lets assume this our hypothetical couple have Hb eleterophoresis done and was told that the genotype of partner 1 is AA, and that of partner 2 is AS ,but the one that is called AA is actually Aβ-Thalassaemia as ealier mentioned. There possible offspring include
I. AA, If the child inherit the normal A from partner 1 and another normal A from partner 2
II. Aβ-Thalassaemia ,If the child inherit β-Thalassaemic A from the partner 1 and normal A from partner 2
III. AS,If the child inherit normal A from partner 1 and S from patner 2
IV. Sβ-Thalassaemia If the child inherit β-Thalassaemic A from partner 1 and S from partner 2
Note that scenario I above will show AA on Hb electrophoresis, scenario ii will show AA on electrophoresis, scenario iii will show AS on electrophoresis and scenario iv will show SS on electrophoresis
I have tried to simplify the medical terms but if you still have a doubt or clarification ask and I will try to shed more light, as much as I can.
 OP, I'd like to thank you for this educative topic. However, you failed in all totality to establish the possibility of AA + AS = SS. There is no scientific nor spiritual conjure that can make that happen. It has never happened and will not happen sir! You have done well by trying to enlighten us on the phenotype - Genotype saga. You don't delve into hemoglobinopathies with misleading information. Mind you, not everyone on this thread is medically inclined, so we all deserved a robust research before dumping it here. The caption of your subject of discussion is very wrong. You would have done better by simply letting us know that what we call genotype is actually phenotype and genotype is quantified at the molecular level using advanced techniques. Have you ever seen an AA who got married to an AS give birth to SS  And if such happens, paternity test would be called for because, it is not on record anywhere. Not in any journal of haematology. OP, I dey fear who no fear you oooh. Haba! It is just like you saying, it is possible for blood group O + O to give birth to a child who is B or A. That is not possible. They can only give birth to a child with blood group O. Finally, oga this your post is misleading, confusing & has no backbone. I dare you to quote some reference. My advice is for you to do a review and re-caption it. 1 Like |
| Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by Protein0: 10:45pm On Jul 15, 2017 |
4. Lets assume this our hypothetical couple have Hb eleterophoresis done and was told that the genotype of partner 1 is AA, and that of partner 2 is AS ,but the one that is called AA is actually Aβ-Thalassaemia as ealier mentioned. there(sic) possible offspring include
I. AA, If the child inherit the normal A from partner 1 and another normal A from partner 2
II. Aβ-Thalassaemia ,If the child inherit β-Thalassaemic A from the partner 1 and normal A from partner 2
III. AS,If the child inherit normal A from partner 1 and S from patner 2
IV. Sβ-Thalassaemia If the child inherit β-Thalassaemic A from partner 1 and S from partner 2
Note that scenario I above will show AA on Hb electrophoresis, scenario ii will show AA on electrophoresis, scenario iii will show AS on electrophoresis and scenario iv will show SS on electrophoresis
I have tried to simplify the medical terms but if you still have a doubt or clarification ask and I will try to shed more light, as much as I can.
[/quote]
According to u, partner 1 is actually Aβ-Thalassaemia (AA on electrophoresis). The β-Thalassaemia copy was read as A on electrophoresis.
Here is my question, why will scenario IV show SS, given that the thalassemic trait (that was read as A in d parent) be read as S in the child?
Thanks |
| Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by logica(m): 10:45pm On Jul 15, 2017 |
joyandfaith:
that is misdiagnosis. I repeat with good clinical history the misdiagnosis can be avoided in clinical practice. the heading is misleading. the heading could have been , "Medical laboratories in Nigeria can misdiagnose AA or AS as SS'' Thank you jare. It appears this was just a click bait. 2 Likes 1 Share |
| Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by tosyne2much(m): 10:46pm On Jul 15, 2017 |
stevecantrell:
its not funny
its 100% scientific fact.
If youre getting married know your genotype, it might save you the cost of a DNA test in future. Are you trying to say that a woman can bring a bastard child home for me to father? |
| Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by sainty2k3(m): 10:47pm On Jul 15, 2017 |
funmisticqueen:
I have research on it, but you seem to be contradicting yourself, you are yet to show me SCIENTIFIC SOURCES supporting your claim. This is not evidence based and you are still stubbornly supporting something you can't even explain clearly. Please what is not clear ? Is that you are not aware the difference between genotype and phenotype Or you don't know that HB electrophoresis done gives a phenotype which might not necessarily be the Genotype as it is less sensitive in picking quantitative defect of Globin gene known as thalassemia You still not clear that someone that is Abeta thalassemia meaning he has one of the A deleted bit the other A is covering up ,such person appears AA on HB electrophoresis |
| Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by Nobody: 10:47pm On Jul 15, 2017 |
Why am i not surprised sgtponzihater is here again to display ignorance eloquently. The issue we have with op is that he cannot accurately backup his claim with scientific evidence. He is busy quoting news articles and that simply isn't done sgtponzihater1:
I did a post on Nigerian doctors days ago, and for some sad reason, it was deleted and I was banned for 24hrs. Nigerian doctors can't see an unfamiliar topic and discuss at an academic level on it, they despise the unfamiliar and are quick to point out quackery. The OP have brought up an academic and post graduate level argument, which while possible invitro, is left with very few example invivo. Mutation as a phenomenon is however valid. Once again well done OP |
| Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by frankia(m): 10:47pm On Jul 15, 2017 |
Na wa oh. How can you give out what u don't av! AA crossed with AS give rise to SS. That's totally IMPOSSIBLE in the world of biological sciences. 1 Like |
| Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by chalondk(m): 10:48pm On Jul 15, 2017 |
sainty2k3:
YES it is not impossible, couples that are AA/AS can give birth to SS , this is how
1. let me differentiate between haemoglobin genotype and haemoglobin phenotype
To get a particular GENOTYPE you have to do a genetic testing or use two or more of the screening test (the conventional electrophoresis that we do + HPLC or other similar test) to confirm the true genotype while hb PHENOTYPE is the appearance /characteristics of an individual haemoglobin on conventional electrophoresis which we loosely refer to as GENOTYPE
Most times when we call ourselves AA,SS,AS we are actually referring to our Haemoglogin PHENOTYPE and NOT GENOTYPE, as most of us don’t do genetic tests, all we do is haemoglobin electrophoresis
2. lets explain the concept of thalasemic trait. Thalassemias are quantitative defect of haemoglobin which means some one can be AA but the one or both A in this person is is absent otherwise known as thalassemia minor and major respectively. If such person run haemoglobin Electrophoresis( the test that we always loosely regard to as genotype) only A band will be seen and such a person will be regarded as AA. But they are also prone to anaemias and some certain abnormal features in the blood depending on the degree in the reduction in the defective A . such individuals can be Aβ-Thalassaemia(otherwise known as thalassaemic trait) if one of the’ A gene’ is normal, or β-Thalassaemia major if both are affected
3. lets merge the two concepts above and form AND SEE THE DIFFERENT PHENOTYPE THAT EXIST AND THE POSSIBLE CORRESPONDING GENOTYPE
If PHENOTYPE is AA the likely GENOTYPES will be AA , Aβ-Thalassaemia
If PHENOTYPE is SS the likely GENOTYPES will be SS, Sβ-Thalassaemia (MEANING THE OTHER ‘A’ THAT WOULD HAVE MADE THIS AN ‘AS’ IS TOTALLY ABSENT) Others might include SD,SG etc though these are very rare
If PHENOTYPE is AS the likely GENOTYPES will be SA (NOTE – ‘S’ COMES BEFORE ‘A’ BECAUSE THE A IS THALASSAEMIC, THOUGH NOT TOTALLY ABSENT AS THE ONE ABOVE ,IT IS SUSBSTANTIALLY REDUCE), or truely AS
4. Lets assume this our hypothetical couple have Hb eleterophoresis done and was told that the genotype of partner 1 is AA, and that of partner 2 is AS ,but the one that is called AA is actually Aβ-Thalassaemia as ealier mentioned. There possible offspring include
I. AA, If the child inherit the normal A from partner 1 and another normal A from partner 2
II. Aβ-Thalassaemia ,If the child inherit β-Thalassaemic A from the partner 1 and normal A from partner 2
III. AS,If the child inherit normal A from partner 1 and S from patner 2
IV. Sβ-Thalassaemia If the child inherit β-Thalassaemic A from partner 1 and S from partner 2
Note that scenario I above will show AA on Hb electrophoresis, scenario ii will show AA on electrophoresis, scenario iii will show AS on electrophoresis and scenario iv will show SS on electrophoresis
I have tried to simplify the medical terms but if you still have a doubt or clarification ask and I will try to shed more light, as much as I can.
Oga you are funny oo.. you mean to tell me if i go a hispital to check for my genotype they would start checking something else and tell me tjat is a my genotype abi?? You are twisting the conversation to say someones genotype is AA but his phenotype is something else.. like that is the talk. CAN PARTNERS OF GENOTYPE AA AND AS GIVE BIRTH TO AN SS CHILD |
| Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by caniva(m): 10:48pm On Jul 15, 2017 |
OP...Pls no dey scare us for here joor.
It's not possible, not even your village people can make SS come out from AA and AS.
Abeg, your big medical and scientific grammar no move us here. |
| Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by Kakamorufu(m): 10:49pm On Jul 15, 2017 |
Tor. so what's the hope for AS like us. Abi what's all these rubbish naw |
| Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by Protein0: 10:50pm On Jul 15, 2017 |
sainty2k3:
YES it is
4. Lets assume this our hypothetical couple have Hb eleterophoresis done and was told that the genotype of partner 1 is AA, and that of partner 2 is AS ,but the one that is called AA is actually Aβ-Thalassaemia as ealier mentioned. there(sic) possible offspring include
I. AA, If the child inherit the normal A from partner 1 and another normal A from partner 2
II. Aβ-Thalassaemia ,If the child inherit β-Thalassaemic A from the partner 1 and normal A from partner 2
III. AS,If the child inherit normal A from partner 1 and S from patner 2
IV. Sβ-Thalassaemia If the child inherit β-Thalassaemic A from partner 1 and S from partner 2
Note that scenario I above will show AA on Hb electrophoresis, scenario ii will show AA on electrophoresis, scenario iii will show AS on electrophoresis and scenario iv will show SS on electrophoresis
I have tried to simplify the medical terms but if you still have a doubt or clarification ask and I will try to shed more light, as much as I can.
According to u, partner 1 is actually Aβ-Thalassaemia (AA on electrophoresis). The β-Thalassaemia copy was read as A on electrophoresis. Here is my question, why will scenario IV show SS, given that the thalassemic trait (that was read as A in d parent) be read as S in the child? Thanks |
| Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by stevecantrell: 10:51pm On Jul 15, 2017 |
tosyne2much:
Are you trying to say that a woman can bring a bastard child home for me to father? Hey im not being personal, just being general in my advice. Ive seen a few marriages crash because the woman was caught out on genotyping . 1 Like |
| Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by sainty2k3(m): 10:51pm On Jul 15, 2017 |
Protein0:
4. Lets assume this our hypothetical couple have Hb eleterophoresis done and was told that the genotype of partner 1 is AA, and that of partner 2 is AS ,but the one that is called AA is actually Aβ-Thalassaemia as ealier mentioned. there(sic) possible offspring include
I. AA, If the child inherit the normal A from partner 1 and another normal A from partner 2
II. Aβ-Thalassaemia ,If the child inherit β-Thalassaemic A from the partner 1 and normal A from partner 2
III. AS,If the child inherit normal A from partner 1 and S from patner 2
IV. Sβ-Thalassaemia If the child inherit β-Thalassaemic A from partner 1 and S from partner 2
Note that scenario I above will show AA on Hb electrophoresis, scenario ii will show AA on electrophoresis, scenario iii will show AS on electrophoresis and scenario iv will show SS on electrophoresis
I have tried to simplify the medical terms but if you still have a doubt or clarification ask and I will try to shed more light, as much as I can.
According to u, partner 1 is actually Aβ-Thalassaemia (AA on electrophoresis). The β-Thalassaemia copy was read as A on electrophoresis.
Here is my question, why will scenario IV show SS, given that the thalassemic trait (that was read as A in d parent) be read as S in the child?
Thanks Scsensrio iv, the genotype is actually Sbeta thalassemia( meaning there is inheritance of one S haemoglobin and the other which is supposed to be A is genetically deleted) on HB electrophoresis only S band will be seen leading being tagged as SS |
| Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by Nobody: 10:52pm On Jul 15, 2017 |
Everything is not clear especially lack of evidence to support your claim. Cos i am sure your refrences if you have any would explain this better in a way that a bricklayer would understand. Also please use paragraphs, they are very key. sainty2k3:
Please what is not clear ?
Is that you are not aware the difference between genotype and phenotype
Or you don't know that HB electrophoresis done gives a phenotype which might not necessarily be the Genotype as it is less sensitive in picking quantitative defect of Globin gene known as thalassemia
You still not clear that someone that is Abeta thalassemia meaning he has one of the A deleted bit the other A is covering up ,such person appears AA on HB electrophoresis
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