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Nairaland Forum / Nairaland / General / Health / Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' (78148 Views)
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Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by jnrremedy(m): 10:52pm On Jul 15, 2017 |
joyandfaith:I partially agree with u but the fact/information the op is trying to give is that a AS AA couple can give birth to a misdiagnosed SS offspring ( a s beta thalessemia) and an informed doctor should call for HPLC test to confirm but what u have is that a doctor will even say it is impossible. this is very misleading 98% of hospitals in Nigeria use gel electrophoresis for blood genotyping to detect or rule out or prevent heamogblobinopathies this is wrong cos gel electrophoresis is wrong and the saddening part is that most doctors don't know and they don't want to know 1 Like |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by joyandfaith: 10:53pm On Jul 15, 2017 |
jnrremedy:yes, it is misdianosis. bad reagents,poor skill, interference,poor history etc can cause misdiagnosis. medical diagnosis is not complete in bench. clinical information/history is not only signs and symptoms. 1 Like |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by perdollar(m): 10:54pm On Jul 15, 2017 |
Mr OP. can u reference me a medical journal were it has bn published or upload evidence of a proven case u av seen. |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by Protein0: 10:56pm On Jul 15, 2017 |
sainty2k3: U r not getting my question. Was it not d thalassemic trait inherited from partner 1? It was read as A in d parent, right? Why as S in d offspring? Modified, d genotype is Sbeta thalassemia in d child just as partner 1's genotype is Abeta thalassemia. |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by tosyne2much(m): 10:56pm On Jul 15, 2017 |
stevecantrell:Nawa ooooh ![]() |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by joyandfaith: 10:56pm On Jul 15, 2017 |
jnrremedy: doctors are right because AA and AS cannot produce SS. if it happens doctors know something is missing or wrong. 1 Like |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by sainty2k3(m): 10:57pm On Jul 15, 2017 |
chalondk:When you go to most Nigeria hospital what they actually check is HB phenotype using HB electrophoresis.a genotype will require genetic testing or some further test to confirm what is seen on HB electrophoresis. To your question if you actually do a genotype , that is the AA And AS was confirmed by DNA analysis , then the possibility of having SS should be zero. But if all you do yo get the AA and AS is from HB electrophoresis ,the common thing we all do the likelihood of Sbeta thalassemia which will appear as SS both clinically and on electrophoresis is still there is there though rare 1 Like |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by Nobody: 10:57pm On Jul 15, 2017 |
Thank you, please tell him o. innosaint27: |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by tosyne2much(m): 10:57pm On Jul 15, 2017 |
oviejnr:This argument pass me ooooo, so I go just pass ![]() |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by Nobody: 10:57pm On Jul 15, 2017 |
innosaint27: 1 Like |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by kenny5811(m): 10:58pm On Jul 15, 2017 |
mtcheeeeew... AA - AS = SS.... wer d 2nd S cum from? 1 Like |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by jnrremedy(m): 10:58pm On Jul 15, 2017 |
funmisticqueen:this is a scientific/medical fact the reason u are not aware is cos beta thalessemia is not that common here ( but it there re sufferers) cos u don't no doesn't mean it does not exist no need to argue just learn this night 1 Like |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by sgtponzihater1(m): 10:59pm On Jul 15, 2017 |
funmisticqueen: This woman! ![]() |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by sainty2k3(m): 10:59pm On Jul 15, 2017 |
joyandfaith:Pls read what jnrremedy just summarized the point for you to grab |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by nelszx: 11:00pm On Jul 15, 2017 |
lexy2014:Yes those are simple medical terminologies that only those in the line will understand with ease. Though some point raises eyebrow but still on still until proven otherwise it's educative. N.B: The op MIGHT be right but one thing stands, this phenomenon can never happen in Nigeria as "Thalassemia trait" can't be found this is part of the world rather what we have is HbS and HbC the reason we have sickle cell disorders on the high side (HbSS and HbSC). The reason I said it raises eyebrow |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by sgtponzihater1(m): 11:01pm On Jul 15, 2017 |
jnrremedy: I have seen some thalasemmic individuals, mostly females. They have far less crises, but still have the risk factors of HbSS, many are obese and come out with a fractured neck of femur, this is actually one of their commonest morbidities. Many junior doctors have rarely seen these cases, and may join the spiritual men to bind and cast when they see patients in these crises. 1 Like |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by sainty2k3(m): 11:01pm On Jul 15, 2017 |
Protein0:Correct |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by MrOlai: 11:02pm On Jul 15, 2017 |
jnrremedy: jnrremedy: |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by lebienconnu: 11:03pm On Jul 15, 2017 |
The HbS heamoglobin is as a result of a point mutation on the chromosome 11 which codes for the beta chain of the haemoglobin. Blood phenotype SS can only ensue if the foetus inherits mutated chr 11 from both parents (homozygotic). Now, AA vs AS shows that only one of the couple has defective chr 11. It is, therefore, scientifically impossible for AA vs AS to produce SS offspring. if the mother's ova duplicates before fertilization and later fuses with the sperm cell an abnormal zygote will form leading to complete hydatidiform mole (69 Bleep or 69XXY), an abnormal pregnancy which definitely autoaborts. This piece of shit is defying the well proven theory of evolution. This is a very shameful article and I am very angry that it made Nairaland first page taking into cognition the position of this forum in the global media. I am also upset and embittered that this trash was written by a Nigerian. |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by Protein0: 11:05pm On Jul 15, 2017 |
sainty2k3: To sign out, what will beta thalassemia major read on electrophoresis? |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by jnrremedy(m): 11:09pm On Jul 15, 2017 |
joyandfaith:pls don't be ignorant to learn this is not a new knowledge. just google and read thalessemia. AS SS couple can give birth to a sickler ( though the not sickle cell sickler). the reason why this new info is new to a lot of peeps is cos beta thalessemia is not that common here compare to Asian countries but it still present here let me tell u a case that happened in sickle cell center igbobi ( u can go to the center and confirm) Two married pharmacist gave birth to a child that showed clinical manifestation of a sickler( gel electrophoresis came out as SS). both parents were confused cos husband was AA and wife was AS. this almost lead to their divorce cos husband accused the wife of cheating then the center in igbobi has no HPLC platform to quantify the heamogblobin when our company ( my formal company) supplied the HPLC platform ( they re currently using now) they used it on the child ( for quantification cos they re the one managing the child) to their up most surprise they discovered the child was AS but beta thalessemia so ( s beta thelesemia) 1 Like |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by Nobody: 11:09pm On Jul 15, 2017 |
naijaking1: ![]() ![]() ![]() Oga I use God beg you, never in your life should you again classify Hb Genotype AS as a type of sickle cell disease (SCD). You and the textbook you copied from are totally wrong. Individuals with HB genotype AS are normal in all sense with those who are AA except that they posses sickle cell trait. This means that, if they get married to another individual who is heterozygote (AS or SC or AC) for the sickle cell trait or homozygote (SS), they stand the risk of producing offsprings with sickle cell disease (SS or SC). Pls, I repeat those with genotype AS are 100% NORMAL. THEY ARE NOT SICKLERS. THEY ONLY CARRY THE SICKLE CELL TRAIT. As for the thalasaemias, their prevalence is extremely low in people of African descents. So, what we ought to be bothered about is SICKLE CELL ANAEMIA (HBSS/HBSC) 1 Like |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by jnrremedy(m): 11:10pm On Jul 15, 2017 |
Protein0: SS |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by Syphonn(m): 11:10pm On Jul 15, 2017 |
sainty2k3: can u help us cross it so we can see where the ss comes from when on parent is AA, ITS UNBELIEVABLE 1 Like |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by sainty2k3(m): 11:11pm On Jul 15, 2017 |
Protein0:Most likely only an A band which might appear faint , then if ur electrophoresis can pick HbA2 you will also see that ban , you are using an acidic medium |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by Protein0: 11:13pm On Jul 15, 2017 |
sainty2k3: ![]() ![]() Check jnrremedy's answer |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by MrOlai: 11:14pm On Jul 15, 2017 |
Please, Doctors in the house, how do you explain the different genotypes we have in the world today in relation to Adam and Eve being the first two persons created by God? What was the likely genotype of Adam? What was the likely genotype of his wife Eve? How could six different genotypes result from two persons? 1 Like |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by Protein0: 11:15pm On Jul 15, 2017 |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by Protein0: 11:15pm On Jul 15, 2017 |
MrOlai: Genetic Mutation |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by sainty2k3(m): 11:15pm On Jul 15, 2017 |
innosaint27: Sicke cell disease- SS,SC,Sbeta thal. Etc simply put S plus other abnormal haemoglobin Sicke cell disorders- S plus any other haemoglobin (normal or abnormal) As, SS,SC Sickle cell anaemia- SS . |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by sainty2k3(m): 11:17pm On Jul 15, 2017 |
Protein0:Yea ,seen ![]() |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by Nobody: 11:18pm On Jul 15, 2017 |
Bros I can tell u , what u posted is utter rubbish |
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