I am o, how have you been.

sgtponzihater1:


This woman! , it's obvious I know my onion, I don't dabble in territories I'm not sure of. When it comes to health, investment, finance, music, and religion, I am comfortable. Hope u are good?

sonofLuci:
oboi nothing concern me o. If she fine well like nadia buari or ik ogbona wife and she SS me I go still marry am

it seems like you like yellow WOMEN that are thick with big a5S

lebienconnu:
The HbS heamoglobin is as a result of a point mutation on the chromosome 16 which codes for the beta chain of the haemoglobin. Blood phenotype SS can only ensue if the foetus inherits mutated chr 16 from both parents (homozygotic).

Now, AA vs AS shows that only one of the couple has defective chr 16. It is, therefore, scientifically impossible for AA vs AS to produce SS offspring.

if the mother's ova duplicates before fertilization and later fuses with the sperm cell an abnormal zygote will form leading to complete hydatidiform mole (69 Bleep or 69XXY), an abnormal pregnancy which will definitely abort.

This piece of shit is defying the well proven theory of evolution. This is a very shameful article and I am very angry that it made Nairaland first page taking into cognition the position of this forum in the global media. I am also upset and embittered that this trash was written by a Nigerian.

Sure you didn't read the article

I think I get the op's point.But op,are there no clinical manifestions in people with Aβ-Thalassaemia?Apart from genetic test,are there no other ways to know that the person is not really AA?
Your heading is really misleading though. AA+ AS can never have an SS child.what they could have is a child with Hb S/β thalassemia,a condition that is very different from SS.So it is a matter of misdiagnosis by the electrophoresis method you mentioned.The AA partner was first of all misdiagnosed, and then the baby.

Protein0:


Genetic Mutation

That means we could still have new more different genotypes in future?

Show refrences, until then your claim doesnt hold water

jnrremedy:

this is a scientific/medical fact the reason u are not aware is cos beta thalessemia is not that common here ( but it there re sufferers) cos u don't no doesn't mean it does not exist
no need to argue just learn this night

sgtponzihater1:


I have seen some thalasemmic individuals, mostly females. They have far less crises, but still have the risk factors of HbSS, many are obese and come out with a fractured neck of femur, this is actually one of their commonest morbidities. Many junior doctors have rarely seen these cases, and may join the spiritual men to bind and cast when they see patients in these crises.

Obviously not in Nigeria, you can never see thalassemic individuals in this part of the world

ChelseaDr:
Op thanks for this because a lot of people may not know this.

It is also important to note that although Sβ-Thalasaemia and Hb SS are both forms of Sickle cell disease, they are completely two different disease conditions with far-reaching impact on the person suffering from them.

While Hb SS is as a result of defect in the quality of haemoglobin, Sβ-thalasaemia is as a result of the quantity of haemoglobins present and to diagnose this one needs quantitative analysis of the haemoglobin chains whereas qualitative analysis is enough to diagnose SS which electrophoresis does.

Again, thank you.
Cheers!!

Your analysis is comprehendable to even a tomatoes seller with no education.
But the OP has muddled up everything, creating unnecessary confusion for many.

He is only seeking to bring to the awareness of people, what alpha & Beta thalassamia are as types of SCD. Dragging sickle cell anaemia (SCA) into it wrongly made it all clumsy.

this is one bad thing about us Nigerians
we don't know how to learn once we see something new that contradicts what we know ( or thing we know ) we ignorantly and blindly fail to logically analyse the new knowledge
our case is like the famous saying
that he who knows not and does not want to know ( or does not know he does not know ) is the greatest fool

Sainty2k3, kindly bring forth more evidences to butress ur point. It's still not convincing. I'm not saying u r wrong but the otherwise of ur claim has evidences with me
I will suggest you differentiate btw how a thalassemic (depending on types if it affects the appearnce) and sickle erythrocyte appear on electrophoresis

Am a scientist tho not practicing but the might be true tho he has used our head. Here in Africa the situation is very very very rare for AA + AS o birth SS.
You guys have flexed your muscles a lot trying to prove thing beyond us. We dont have adequate equipment to prove such fact for now.
Though I am yet to see any well written journal that has published this topic on NCBI etc.

But thank God I and my wife are both AA and if by chance any onf my kids show AS the Op will come and tell me how possible that is. Then I will know the OP is from another planet.

sainty2k3:

Pls read what jnrremedy just summarized the point for you to grab

you are talking nonsense. I repeat it is not possible. you are still proven nonsense. it is misdiagnosis which is caused by med lab. ur heading and explanation are misleading. if you continue, u will harm someone. sb thal is different from ss, so AA and AS cannot produce SS. if gel electrophoresis shows SS, it is misdiagnosis, not that AA and AS produce SS. I am very sure u do not understand the journal and u have poor knowledge of molecular pathogenesis of hemoglobininopathies. pls, my friend read,discuss,ask questions and reflect before you post health information . misinformation is worse than no information just as no diagnosis is better than misdiagnosis .

MrOlai:


That means we could still have new more different genotypes in future?

Maybe

Hahahaha Op,its obvious that you a native doctor because if you are a medical doctor, you won't post this impossible calculation.... AA/AS can't n produce SS.

Anyways thanks for wasting time

MrOlai:


That means we could still have new more different genotypes in future?

sir we already have more than 200 classified genotypes
there is even one called after Ibadan cos it was first described in Ibadan
A S and C and D are just the most common with clinical significance

sainty2k3:

When you go to most Nigeria hospital what they actually check is HB phenotype using HB electrophoresis.a genotype will require genetic testing or some further test to confirm what is seen on HB electrophoresis.

To your question if you actually do a genotype , that is the AA And AS was confirmed by DNA analysis , then the possibility of having SS should be zero.
But if all you do yo get the AA and AS is from HB electrophoresis ,the common thing we all do the likelihood of Sbeta thalassemia which will appear as SS both clinically and on electrophoresis is still there is there though rare

So this is misdiagnosis, not so? Just make sure you clarify for all these people so that they don't go around bandying wrong information. All that long explanation you put in the OP will just be gleaned over. Thank you.

lisbonabdulahi:
what is the chance of this happening, and when last did we see one

Chances are slim as they are rare but its a possibility

ChelseaDr:
Op thanks for this because a lot of people may not know this.

It is also important to note that although Sβ-Thalasaemia and Hb SS are both forms of Sickle cell disease, they are completely two different disease conditions with far-reaching impact on the person suffering from them.

While Hb SS is as a result of defect in the quality of haemoglobin, Sβ-thalasaemia is as a result of the quantity of haemoglobins present and to diagnose this one needs quantitative analysis of the haemoglobin chains whereas qualitative analysis is enough to diagnose SS which electrophoresis does.

Again, thank you.
Cheers!!

How's the quality of a thalassemic hemoglobin sir if Sbeta thalassemia is a result of the quantity of HB present?

sainty2k3:


Sicke cell disease- SS,SC,Sbeta thal. Etc simply put S plus other abnormal haemoglobin

Sicke cell disorders- S plus any other haemoglobin (normal or abnormal) As, SS,SC

Sickle cell anaemia- SS .

I can't help but just laugh!!!!!

For your info, I am an hematologist. My focus on this thread is SCD (SS & SC) excluding the thalassamias and other hemoglobinopathies. Until you re-caption the title, I won't bother myself with the thalassemias.

BTW, don't quote me again unless you have something of worth to point out.

Stop confusing yourself and confusing others who have little or no knowledge about the subject matter.

sainty2k3:

When you go to most Nigeria hospital what they actually check is HB phenotype using HB electrophoresis.a genotype will require genetic testing or some further test to confirm what is seen on HB electrophoresis.

To your question if you actually do a genotype , that is the AA And AS was confirmed by DNA analysis , then the possibility of having SS should be zero.
But if all you do yo get the AA and AS is from HB electrophoresis ,the common thing we all do the likelihood of Sbeta thalassemia which will appear as SS both clinically and on electrophoresis is still there is there though rare

Op......i think i grab your point.....it is not possible for AA And AS couple to give birth to SS but SB but usually most lab will just tell you SS because of testing they use,am i correct.

Saint83:
Hahahaha Op,its obvious that you a native doctor because if you are a medical doctor, you won't post this impossible calculation.... AA/AS can't n produce SS.

Anyways thanks for wasting time

. Read well and research more

sainty2k3:

When you go to most Nigeria hospital what they actually check is HB phenotype using HB electrophoresis.a genotype will require genetic testing or some further test to confirm what is seen on HB electrophoresis.

To your question if you actually do a genotype , that is the AA And AS was confirmed by DNA analysis , then the possibility of having SS should be zero.
But if all you do yo get the AA and AS is from HB electrophoresis ,the common thing we all do the likelihood of Sbeta thalassemia which will appear as SS both clinically and on electrophoresis is still there is there though rare

Op......i think i grab your point.....it is not possible for AA And AS couple to give birth to SS but SB but usually most lab will just tell you SS because of testing they use,am i correct?

joyandfaith:

you are talking nonsense. I repeat it is not possible. you are still proven nonsense. it is misdiagnosis which is caused by med lab. ur heading and explanation are misleading. if you continue, u will harm someone. sb thal is different from ss, so AA and AS cannot produce SS. if gel electrophoresis shows SS, it is misdiagnosis, not that AA and AS produce SS. I am very sure u do not understand the journal and u have poor knowledge of molecular pathogenesis of hemoglobininopathies. pls, my friend read,discuss,ask questions and reflect before you post health information . misinformation is worse than no information just as no diagnosis is better than misdiagnosis .

pls go to igbobi sickle cell center and ask the scientist there to lecture u
or come to hematology lab in Ibadan here or visit prof abiesuku lab in pathology to explain or
go to Akure specialist hospital and ask for Dr osho or the head of the doctors lab to explain to u

ignorance is not good
update ur knowledge of heamogblobinopathies

nelszx:

Obviously not in Nigeria, you can never see thalassemic individuals in this part of the world

I tire o.
I'll love to see one too sef.

SAVEDBABA:
Op......i think i grab your point.....it is not possible for AA And AS couple to give birth to SS but SB but usually most lab will just tell you SS because of testing they use,am i correct.

Correct. That's the exact point

Many here seem not to fully understand the OP and I think the topic too is quite misleading. What I understand from the OP's submission is that: Someone classified as AA may actually be Aβ and when such produces a child with an AS partner, the child can be Sβ which can easily be wrongly diagnosed(classified) as SS by electrophoresis. Can't type much jare.

SAVEDBABA:
Op......i think i grab your point.....it is not possible for AA And AS couple to give birth to SS but SB but usually most lab will just tell you SS because of testing they use,am i correct?

exactly and a lot of wrong diagnosis has been made by these doctors and lab scientist some even braking homes cos of their ignorance of possibility of AS AA giving bath to a sickler
they believe sucklers are only given birth to by only AS AS or SS couples

And how did this post enter FP, seun abeg this info is false and misleading, let your mods take it down before it misleads more people, in all years in da science world, no theory can prove how AA and AS will give birth to SS except OP's theory. Chai, thank God say we too go school small.....

zicoy6k:
Many here seem not to fully understand the OP and I think the topic too is quite misleading. What I understand from the OP's submission is that: Someone classified as AA may actually be Aβ and when such produces a child with an AS partner, the child can be Sβ which can easily be wrongly diagnosed(classified) as SS by electrophoresis. Can't type much jare.

thank God some people are learning here
u are correct sir but the sad thing is that doctors lab scientist and even the lay man don't know
reason am really interested in this thread this night

nelszx:

Obviously not in Nigeria, you can never see thalassemic individuals in this part of the world

Why do we have these kind of dudes pls?, they don't know and avoid learning. Use the internet. Type thalassemia in Nigeria, tell me what u get. Shit!

sainty2k3:

Most likely only an A band which might appear faint , then if ur electrophoresis can pick HbA2 you will also see that ban , you are using an acidic medium

Thalassemia wouldn't show anything (A or SS) on Hb electrophoresis. You might see HbH (Barts Haemoglobin) but definitely not A band or SS , it's best diagnosed using CBC (HB and the RBC indices) with Ferritin level

Hmmm