mayoor15:
And how did this post enter FP, seun abeg this info is false and misleading, let your mods take it down before it misleads more people, in all years in da science world, no theory can prove how AA and AS will give birth to SS except OP's theory. Chai, thank God say we too go school small.....

jnrremedy:

pls don't be ignorant to learn this is not a new knowledge. just google and read thalessemia. AS SS couple can give birth to a sickler ( though the not sickle cell sickler).
the reason why this new info is new to a lot of peeps is cos beta thalessemia is not that common here compare to Asian countries but it still present here
let me tell u a case that happened in sickle cell center igbobi ( u can go to the center and confirm)

Two married pharmacist gave birth to a child that showed clinical manifestation of a sickler( gel electrophoresis came out as SS). both parents were confused cos husband was AA and wife was AS. this almost lead to their divorce cos husband accused the wife of cheating
then the center in igbobi has no HPLC platform to quantify the heamogblobin
when our company ( my formal company) supplied the HPLC platform ( they re currently using now) they used it on the child ( for quantification cos they re the one managing the child) to their up most surprise they discovered the child was AS but beta thalessemia so ( s beta thelesemia)

edeXede:


Op, let me help me simplify it

In summary, it is not possible under correct diagnosis for AA and AS to produce SS

except

AA was misdiagnosed, meaning he is actually AS but was misdiagnosed as AA.

---

Dont come here and be telling us 1+1=1
Na lie. 1+1=2

jnrremedy:

I partially agree with u but the fact/information the op is trying to give is that a AS AA couple can give birth to a misdiagnosed SS offspring ( a s beta thalessemia) and an informed doctor should call for HPLC test to confirm but what u have is that a doctor will even say it is impossible. this is very misleading

98% of hospitals in Nigeria use gel electrophoresis for blood genotyping to detect or rule out or prevent heamogblobinopathies
this is wrong cos gel electrophoresis is wrong and the saddening part is that most doctors don't know and they don't want to know

Protein0:
Well, Sainty2k3 ur msg was well deciphered but not the picture you painted really.
What u actually meant was that Abeta thalassemia (that a typical Nigerian lab will report as AA) +AS can yield Sbeta thalassemia (that a typical Nigerian lab will report as SS). This is a fact!

However, d only way a couple with "real" Hb AA and AS (not Nigerian's) can produce a child of Hb SS is if a "third party" is involved.

A doctor can't say if a supposed genotype result has thalassemic copy, even if he's sure it was based on electrophoresis alone.
Kindly call on d mods to modify d topic to avoid that break up of this love birds out there.

jnrremedy:

u are very wrong ma carefully reread contributions here and learn there is nothing new in wot the op is saying and it is a medical fact
u can on your own google haemoglobin opting and learn

Nigerians like to prodly flaunt their ignorance

funmisticqueen:
Nobody with knowledge has actually agreed with your theory not to talk of simplifying it

jnrremedy:

exactly and a lot of wrong diagnosis has been made by these doctors and lab scientist some even braking homes cos of their ignorance of possibility of AS AA giving bath to a sickler
they believe sucklers are only given birth to by only AS AS or SS couples

joyandfaith:


I know. I still maintain that op is misleading. no haematogist will label a child SS when parents are AA and AS. more questions need to be asked. that is standard practice. in above case, genetic testing or chromatography could solve the problem.medical diagnosis does not stop in bench. besides, we disagree with op heading. there is discordant between heading and explanation given by op. even explanation is shallow and not appropriate for non-health workers.
you are asked me to read about thal? you must be kidding or joking. if you want info on thal even molecular pathogrnesis, newer diagnostic methods, pls open another thread. you guys know few things and start spitting meconium. he should change the heading to " MEDICAL LABORATORIES IN NIGERIA CAN MISDIAGNOSE AA or AS as SS''. it would make sense.

sainty2k3:

Correct. That's the exact point

Scholar212:
OP can you cite any medical journal to buttress your claim, in all my haematology classes and even deep lectures on blood grouping, genotype and haemoglobinopathies I have never come across such not online, textbook or lecture. The burden of prove now lies on you to justify your claim of co-dominant thalasemia trait and HB genotype

SAVEDBABA:
Quite educative though, but based on your write up.... the child is not actually SS but SB,but everybody took it as SS.Educative though.

donhils:
When articles/information like this come up, it is expected we see a [/b]credible[b] source because some people might swallow everything here hook, line and sinker.

jnrremedy:


pls go to igbobi sickle cell center and ask the scientist there to lecture u
or come to hematology lab in Ibadan here or visit prof abiesuku lab in pathology to explain or
go to Akure specialist hospital and ask for Dr osho or the head of the doctors lab to explain to u

ignorance is not good
update ur knowledge of heamogblobinopathies

SAVEDBABA:
Op......i think i grab your point.....it is not possible for AA And AS couple to give birth to SS but SB but usually most lab will just tell you SS because of testing they use,am i correct.

innosaint27:






Your suggested topic to the OP is very unattractive & troublesome. You are throwing punches at the medical laboratory profession without any cause or evidence that they have misdiagnosed someone.

E b lyk say u like fight ba?


He can try; Diagnosing the thalassamias, common limitations in Nigeria.

sainty2k3:
You are right

CanadianNurse:
OP your heading/title is wrong

Genotype AAv can never form SS when combined with AS

TThat people do the mistake of interchanging their phenotype or Genotype doesn't make it possible for AA +As to give sS


If my Genotype is AA I can even marry an SS..with little or no chance of producing SS

oluezekiel:

Summary of the whole argument I believe. I don't know why people are abusing the op instead analysing it logically.

AmbFitsaint:


Na you oo
Even consulatant haemotogist no sabi these stiffs wey u just move

NwaAmaikpe:


Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS'

Of course it is possible.

That 'AA' is married to an 'AS' does not mean that
the 'AS' can not shag another 'AS' on the side and bring in a bastard 'SS'

---

Please don't believe this nonsense... Very soon, one confused scientist will bring up a theory claiming it is possible for paternity tests to come back negative when you are truly the father.

joyandfaith:


I know. I still maintain that op is misleading. no haematogist will label a child SS when parents are AA and AS. more questions need to be asked. that is standard practice. in above case, genetic testing or chromatography could solve the problem.medical diagnosis does not stop in bench. besides, we disagree with op heading. there is discordant between heading and explanation given by op. even explanation is shallow and not appropriate for non-health workers.
you are asked me to read about thal? you must be kidding or joking. if you want info on thal even molecular pathogrnesis, newer diagnostic methods, pls open another thread. you guys know few things and start spitting meconium. he should change the heading to " MEDICAL LABORATORIES IN NIGERIA CAN MISDIAGNOSE AA or AS as SS''. it would make sense.

joyandfaith:


because op thinks he is talking to health workers or medical researchers. many people here cannot analyze it logically. we could have helped him to analyze if topic is changed.

sod09:
don't mind the op
He's saying total rubbish

sainty2k3:

Engage any consultant hematologist with this write up ,they will explain it to you, probably better

jnrremedy:

being low doesn't mean they don't exist
I have seen a personal case of misdiagnosis by the same medical personnel cos of their poor knowledge of heamogbobinopahty this is just like an awareness to sensitive the populace

even here on Nairaland some years back ( 3 yrs) someone brought up a personal case and everybody Ill advice the person involved ( including me cos then I was not informed) they concluded the wife cheated cos the hospital/ lab result keep coming as HbSS while parents are Hb AA/AS

SAVEDBABA:
You need to change your topic then.*cheers*

joyandfaith:


better. but it will not hit front page.

joyandfaith:


Tell Dr Abiessuku of Chemical pathology you have poor knowledge of hemoglobininopathies. Tell Dr Osho P.O that you were sleeping in class during lectures. Partial knowledge is your problem. Pls, do not say AA and AS can produce SS in any conference. if you do, u get know in ur head. so, if chromatographymedical or pcr is used, AA and AS will still produce SS. nonsense.