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Nairaland Forum / Nairaland / General / Health / Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' (78437 Views)
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Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by joyandfaith: 12:17am On Jul 16, 2017 |
sainty2k3: change the topic first.we can start from there.thanks. |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by sainty2k3(m): 12:17am On Jul 16, 2017 |
joyandfaith:That's the issue, how many people in Nigeria use genetic studies or HPLC to find out there HB genotype . all people do is HB electrophoresis and say they are AA ,AS or SS and those are the people my topic refers to , note that in the topic I didn't say that's there genotype. that's the phenotype, they wrongly refer to it as genotype. |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by oluezekiel(m): 12:19am On Jul 16, 2017 |
joyandfaith:Sincerely speaking, I got it from his first post but was feeling lazy to type. Thanks to you our 'ogas' in the medical field for bringing out more explanations to conclude it. But please, let's try to be more accommodating in our arguments. I've gained more. |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by jnrremedy(m): 12:19am On Jul 16, 2017 |
innosaint27: this case is not an issue of quakery all the diagnostic test were right but judgement was poor by the doctor PR medical scientist handling the case cos they have little knowledge about it even if the test was repeated in teaching hospital it will still come out the same its only someone knowledgeable that will ask for further investigation before conclusion can be made |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by sainty2k3(m): 12:20am On Jul 16, 2017 |
jnrremedy:Don't mind him. From his latest post I can see he has understood the analysis u made. |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by joyandfaith: 12:21am On Jul 16, 2017 |
jnrremedy: but you are defending op misleading topics. no doctor knows it all. and you do not generalize ok. |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by joyandfaith: 12:23am On Jul 16, 2017 |
sainty2k3: ur topic is wrong. |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by RapportNaija(m): 12:23am On Jul 16, 2017 |
wonderful insight into this Hb AC and Hb CC, AA AS things |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by sainty2k3(m): 12:24am On Jul 16, 2017 |
innosaint27: U mean all over the word HB electrophoresis is the conventional way for genotype testing? No, at least not alone, people combine with HPLC, FBC and blood film findings , other screening test to confirm the genotype if molecular studies will not be done |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by jnrremedy(m): 12:25am On Jul 16, 2017 |
joyandfaith: your argument says otherwise |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by joyandfaith: 12:25am On Jul 16, 2017 |
sainty2k3: which analysis? what I know. it is topic that drags us to this level. it is misleading. see my first 2 posts. |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by jnrremedy(m): 12:27am On Jul 16, 2017 |
sainty2k3: and he is an hematologist oooo |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by sainty2k3(m): 12:27am On Jul 16, 2017 |
joyandfaith:, did the topic say genotype AA, can you see it 'AA' . what do you want the topic to look like, just responding to you cos I could sense you are a pathologist or pathologist in training. I think you need to be more explorative and open to learning new things . bye |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by jnrremedy(m): 12:29am On Jul 16, 2017 |
joyandfaith:there is nothing misleading in the op post someone with the knowledge should grab wot op was saying from the beginning u just wanted to prove its ur field so u know it all |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by joyandfaith: 12:29am On Jul 16, 2017 |
sainty2k3: so are looking for analyzer because you did not understand d journal.understand textbook first before you read journal. |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by sainty2k3(m): 12:31am On Jul 16, 2017 |
Syphonn: Someone got it crossed here https://www.stjude.org/treatment/disease/sickle-cell-disease/diagnosing-sickle-cell/beta-thalassemia-trait.html |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by naijaking1: 12:32am On Jul 16, 2017 |
sainty2k3: If you electrophorese valine and lysine will they come out the same? If you correctly answered no, then there is no way a good technologist will come to my office to tell me that the B-thal and Beta or alpha-thal are now migrating to the same spot on the plate. Unless your reagents are bad. And, I think this is where you got confused. The two hemoglobinopathies don't have the same electrophoretic pattern in a good lab! So that patient you had classified as AA, or AS might have been wrong in the first place. |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by Nobody: 12:33am On Jul 16, 2017 |
5 consultants of which 3 are professors, eight senior registrars, need i say more, i would have asked them but maybe during the week. sainty2k3: |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by sainty2k3(m): 12:33am On Jul 16, 2017 |
joyandfaith:You don't need to be insultive as you have been , just take your time, one day in your practice this fact will be useful to you |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by sainty2k3(m): 12:35am On Jul 16, 2017 |
funmisticqueen:Alright we can talk about it when you have asked them. I heard it first directly from one of the country's greatest professor of haematology, and I have also verified it, seen this kind of scenarios |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by joyandfaith: 12:37am On Jul 16, 2017 |
sainty2k3: I should learn AA and AS producing SS babies in ur laboratory. lol. ur topic can cause panic attacks. topic should be " MEDICAl LABORATORIES IN NIGERIA CAN MISDIAGNOSE AA or AS as SS'' You will now explain what people should do. that is public health education. public health information is not about bragging but to help people make right health decisions. 4 Likes |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by sainty2k3(m): 12:39am On Jul 16, 2017 |
naijaking1:In the concept of thalassemia, one or more of the globin gene is deleted or mutated , so what is absent can not move, and yes, HbSS and HbS- b thal, will look similar on alkaline media electrophoresis |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by sainty2k3(m): 12:42am On Jul 16, 2017 |
nelszx:I guess we are all right , u know thalassemia is I'm spectrum ; it could be totally absent or partially absent, so in partial absence whatever is left will still be seen on electrophoresis Either its A or S |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by Oyinlomobambam(m): 12:43am On Jul 16, 2017 |
What's the possibility of AA to SS? |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by joyandfaith: 12:44am On Jul 16, 2017 |
sainty2k3: which fact? I do not ur info. if you want 20 journals on misdiagnosis in hemoglobin testing, I shall provide the links. it is ur annoying argument that take us here. initially, you were told that information is misleading but u refused to listen. |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by nelszx: 12:46am On Jul 16, 2017 |
sgtponzihater1:OK let's assume you have seen, at what frequency (rate) and what part of Nigeria did you see them. We learn everyday you know |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by joyandfaith: 12:46am On Jul 16, 2017 |
sainty2k3: the professor will deny u. u did not understand what professor said. |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by sainty2k3(m): 12:47am On Jul 16, 2017 |
joyandfaith:Please go and sleep, there is no argument read the post, I separated phenotype from genotype and explained thalassemia briefly, no misleading information. |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by sainty2k3(m): 12:47am On Jul 16, 2017 |
joyandfaith: |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by naijaking1: 12:51am On Jul 16, 2017 |
sainty2k3: Ok, once again, the difference is valine and lysine. If you don't know already, the genetic pair of the beta globulin chain of the hemoglobin is mutated, and they transcribe these amino acids instead of glutamic acid. Presence of valine or lysine changes the PH and pk values of the new hemoglobin solution so they sickle and deform in shape-a condition that makes the spleen pit them out of the circulation with resulting anemia, vaso-occlussive conditions, etc. The electrophoresis picks up the transcribed elements, while gene splicing is what you need to make the diagnosis at the sequencing level. |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by sainty2k3(m): 12:54am On Jul 16, 2017 |
naijaking1:Talking about valine and lysine you are probably referring to HbS and HbC respectively, not thalassemia |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by naijaking1: 12:55am On Jul 16, 2017 |
sainty2k3: The site is ok for patient education, it is too basic and simplistic for physicians and serious scientist. It might be a good idea for you to make an appointment with your doctor for better explanation of this topic. It's better to look at the whole elephant, and not just the trunk, ears, or nose in isolation. You have to understand the big picture. |
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