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Nairaland Forum / Nairaland / General / Health / Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' (78126 Views)
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Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by sainty2k3(m): 12:56am On Jul 16, 2017 |
naijaking1:Now that's funny. |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by naijaking1: 12:57am On Jul 16, 2017 |
sainty2k3: If the glutamic acid mutates to valine, we have Beta-s, or HbS. Mutation to lysine gives rise to thalassamia |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by naijaking1: 12:58am On Jul 16, 2017 |
sainty2k3: There's nothing funny about this. |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by Nobody: 12:59am On Jul 16, 2017 |
anyebedgreat: Not always @op, great job. Very educative 2 Likes |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by sainty2k3(m): 1:03am On Jul 16, 2017 |
naijaking1:Nooo, u need to verify your facts sir |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by sainty2k3(m): 1:04am On Jul 16, 2017 |
Chi59:Thanks |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by Nobody: 1:04am On Jul 16, 2017 |
Funny how I see comments saying "it's not possible." I may not be a doctor but I've heard of rare cases. Even the one caused by Mosaicism. Abeg read wide. |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by lisbonabdulahi: 1:10am On Jul 16, 2017 |
sainty2k3:in medicine, common aikement are common. Did you read the history of the woman?. The truth is dat, theoretically it can happen, but I have never seen a case in practice |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by sainty2k3(m): 1:14am On Jul 16, 2017 |
lisbonabdulahi:you are right common things occurs commonly, but a friend did a research on thalassemia prevalence in Nigeria ,not sure if he has published it though, but he found that thalassemia are not as uncommon as we think they are 1 Like |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by logica(m): 1:20am On Jul 16, 2017 |
Chi59:Example of the miseducation we are talking about. Yes, it is ALWAYS. And you only get a different result when most likely the AA result was actually wrong; rather Aß. 1 Like |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by jnrremedy(m): 1:21am On Jul 16, 2017 |
sainty2k3:thanks op for bringing this up this night am sure a lot of people have learnt even the ignorant hematologist ( he just can't shamefully agree publicly after arguing blindly) Good night |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by lisbonabdulahi: 1:24am On Jul 16, 2017 |
sainty2k3:hmmmm, that will be a good read . when is he completing the work.? Hope you keep us updated |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by sainty2k3(m): 1:25am On Jul 16, 2017 |
lisbonabdulahi: Yea will.do that |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by sainty2k3(m): 1:26am On Jul 16, 2017 |
jnrremedy:One love brother |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by lisbonabdulahi: 1:31am On Jul 16, 2017 |
sainty2k3:please. libonabdulahi@yahoo.com . I may be able to get it reviewed here in Finland in a community magazine. If it gets published, your friend may get some contacts, I am just saying. |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by chris51(f): 2:00am On Jul 16, 2017 |
It's impossible for AA & AS to produce an SS child. Pleasedo not deceive and confuse people. This is not spiritual, it is medical. lisbonabdulahi: |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by naijaking1: 2:07am On Jul 16, 2017 |
sainty2k3: I meant substitution of lysine gives rise to Hb SB-thalassemia and others like C and E |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by damocheezy(m): 2:19am On Jul 16, 2017 |
OP thanks but your explanation does not explain how AA and AS can give birth to SS. You are only explaining another concept entirely. 1 Like |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by kindkingsley: 2:35am On Jul 16, 2017 |
Please can blood group A+(positive) Father and 0+(positive) Mother give birth to A-(negative) Son blood group? quote author=sainty2k3 post=58465800]YES it is not impossible, couples that are AA/AS can give birth to SS , this is how 1. let me differentiate between haemoglobin genotype and haemoglobin phenotype To get a particular GENOTYPE you have to do a genetic testing or use two or more of the screening test (the conventional electrophoresis that we do + HPLC or other similar test) to confirm the true genotype while hb PHENOTYPE is the appearance /characteristics of an individual haemoglobin on conventional electrophoresis which we loosely refer to as GENOTYPE Most times when we call ourselves AA,SS,AS we are actually referring to our Haemoglogin PHENOTYPE and NOT GENOTYPE, as most of us don’t do genetic tests, all we do is haemoglobin electrophoresis 2. lets explain the concept of thalasemic trait. Thalassemias are quantitative defect of haemoglobin which means some one can be AA but the one or both A in this person is is absent otherwise known as thalassemia minor and major respectively. If such person run haemoglobin Electrophoresis( the test that we always loosely regard to as genotype) only A band will be seen and such a person will be regarded as AA. But they are also prone to anaemias and some certain abnormal features in the blood depending on the degree in the reduction in the defective A . such individuals can be Aβ-Thalassaemia(otherwise known as thalassaemic trait) if one of the’ A gene’ is normal, or β-Thalassaemia major if both are affected 3. lets merge the two concepts above and form AND SEE THE DIFFERENT PHENOTYPE THAT EXIST AND THE POSSIBLE CORRESPONDING GENOTYPE If PHENOTYPE is AA the likely GENOTYPES will be AA , Aβ-Thalassaemia If PHENOTYPE is SS the likely GENOTYPES will be SS, Sβ-Thalassaemia (MEANING THE OTHER ‘A’ THAT WOULD HAVE MADE THIS AN ‘AS’ IS TOTALLY ABSENT) Others might include SD,SG etc though these are very rare If PHENOTYPE is AS the likely GENOTYPES will be SA (NOTE – ‘S’ COMES BEFORE ‘A’ BECAUSE THE A IS THALASSAEMIC, THOUGH NOT TOTALLY ABSENT AS THE ONE ABOVE ,IT IS SUSBSTANTIALLY REDUCE), or truely AS 4. Lets assume this our hypothetical couple have Hb eleterophoresis done and was told that the genotype of partner 1 is AA, and that of partner 2 is AS ,but the one that is called AA is actually Aβ-Thalassaemia as ealier mentioned. There possible offspring include I. AA, If the child inherit the normal A from partner 1 and another normal A from partner 2 II. Aβ-Thalassaemia ,If the child inherit β-Thalassaemic A from the partner 1 and normal A from partner 2 III. AS,If the child inherit normal A from partner 1 and S from patner 2 IV. Sβ-Thalassaemia If the child inherit β-Thalassaemic A from partner 1 and S from partner 2 Note that scenario I above will show AA on Hb electrophoresis, scenario ii will show AA on electrophoresis, scenario iii will show AS on electrophoresis and scenario iv will show SS on electrophoresis I have tried to simplify the medical terms but if you still have a doubt or clarification ask and I will try to shed more light, as much as I can. [/quote] |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by Nobody: 2:56am On Jul 16, 2017 |
logica: How much do you know about sickle cell? Being one myself, I've read lots of articles and spoken with several doctors about it. Mr miseducation. |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by logica(m): 3:04am On Jul 16, 2017 |
Chi59:I am quite sure you have learnt a lot, and know a lot. ![]() |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by BobbyDean(m): 3:07am On Jul 16, 2017 |
dreshemokha:abi o. OP i hope you know there's a difference between sickle cell anaemia, sickle cell disease & sickle cell trait? Sickle cell anaemia=SS, sickle cell disease= haemoglobin S+ any other abnormal haemoglobin(thalassaemias, haemoglobin C,D & so on), sickle cell trait=haemoglobin A+S that is AS. Pls dont misinform Nigerians, it's the last thing we need cos there are too many wrong info already |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by shreck(m): 5:21am On Jul 16, 2017 |
sainty2k3: Hello guys, I think the confusion is revolving around the information or knowledge each person has. Have you guys factored this fact, we actually have not just AS, AA, SS. we actually have have. AA,AC,AS,SC,SS, CC AC, and CC based on common testing fall falsely under AA and SS. just my 1pence, I am no medical man. seems I happen to be AC but no one knew for years. until I was forced to investigate a recurring health issue doctors could not diagonise Like I stated I am no health person, I am willing to be educated on this life changing issue. Look here. https://m.facebook.com/LAUMSITESYWC/posts/668789426506335 |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by femi4: 5:22am On Jul 16, 2017 |
Chi59:That you are sickle cell doesn't mean you are informed 1 Like |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by Mrlouis: 5:25am On Jul 16, 2017 |
LionDeLeo: O ya werey ni? |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by femi4: 5:28am On Jul 16, 2017 |
shreck:That's how people like you fail exam The question here is simple , Can a full blown well diagnosed AA and AS produce SS? The answer is NO |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by shreck(m): 5:33am On Jul 16, 2017 |
[quote author=femi4 post=58501206]That's how people like you fail exam Well you take opportunity to insult |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by femi4: 5:36am On Jul 16, 2017 |
shreck:even with traces of C, its not possible to have SS.....don't deviate from the main topic 1 Like |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by Mrlouis: 5:40am On Jul 16, 2017 |
jnrremedy:Hey friend, u need not bother yourself to explain to them. Perhaps, one will learn the hard way from his/her offsprings. Only one with a shallow I.Q will find it difficult understanding what's written aboard. Now in simpler terms to non-geeks, he never said marrying an AS as an AA on ideal grounds with every constant equal will give you an offspring with SS genotype... But what he is saying in earnest is that to determine the genotype of a person supposedly called an AA, undergoing tests the wrong way may not actually prove such a one is AA in reality and thus may lead to ones offspring being an SS if he/she marries an AS. The probability of that is high. Genotype issues are deep. Discoveries are made constantly. Now if you don't understand the above, don't quote. Face front Science as well as its methodology evolve.For you see, there was a time Dalton said it was impossible to split the atom (confirm that from the annals of science) but its possible today. Besides how many planets were we taught in secondary school that exist? 9 right....now any trending scientist knows otherwise but only an outdated person will still argue they are still 9. SO Y'ALL JUST GROW UP |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by Nedsnow(m): 5:49am On Jul 16, 2017 |
Am so surprised am seeing so many people claiming to be medical practitioners arguing this OP article. No wonder our ministry of health is dying. Most of you have refused to acquire more knowledge and make your own personal researches on them. All you ve been sticking to are all those old researches and beliefs. OP! Am with you on this. I have seen the way you ve tried explaining to this people, but they wont just understand. But all of you should note this. He never said the SS is the real SS sickler. What most of you lack here is simple comprehension and understanding |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by megafone: 5:51am On Jul 16, 2017 |
sainty2k3: This will be interesting to baby mamas, married but playing always, Unilag girls etc |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by mytym1: 5:55am On Jul 16, 2017 |
sainty2k3:Op you can lie eeh , so you mean my biology teachers and psychology lecturer's lied to me and some text books lied also, no I don't believe you. AA+AS can't produce SS |
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