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Nairaland Forum / Nairaland / General / Health / Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' (78433 Views)
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Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by peacettw: 7:33am On Jul 16, 2017 |
sainty2k3: No pls thank you for creating a thread on this. I have had at least 5 cases on this and when I researched, it became clear. I wish we can reach out to more people and our laboratories too so that these cases can be addressed amicably |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by sod09(m): 7:37am On Jul 16, 2017 |
peacettw:pls we shd know wat ever we seein Google are posted by pple like u AND i Here's is a chart of AA and AS Dis Was how I was taught in school
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Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by barcaboi(m): 7:41am On Jul 16, 2017 |
ChelseaDr:this is just trying to play on our intelligence using medical jargon. That is how u mislead people into going into marriages based on mathematical jargon and ignoring medical advice and thereby giving more SS kids that deserves better...... |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by korm2me(m): 7:41am On Jul 16, 2017 |
joyandfaith:Thank you ma am |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by peacettw: 7:43am On Jul 16, 2017 |
sod09: Redraw d chart but this time with AA and AC. Thanks
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Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by practicalclass: 7:47am On Jul 16, 2017 |
sainty2k3: #a long post but worth reading OP lets shine more light on what Sickle cell Hemoglobin is: HbSS means the hemoglobin has on of the amino acid of its protein component switched i.e valine instead of glycine (this is molecular biology/genetics). This makes the red blood cell (RBC) to be abnormally shaped i.e it is sickled hence it cant carry the normal amount of oxygen normal RBC carry, and it has a shorter half life (<<120 days). This explains some of the symptoms of sickle cell disease. On the Hb electrophoresis the Hb S band is seen in sickle cell. (Explaining the concept of electrophoresis is another write up on its own but it uses the concept of chromotography (basic chemistry). In Thalassemias, we have inadequate globin chains that make up hemiglobin (e.g HbAA is two alpha and two beta chains, but in thalassemia, you have say two alpha and one beta or two alpha and no beta). This globin chains carry different genetic information (this is like computer coding). In thalassemia, the symptoms are different, likewise what you see on electrophoresis cause you are dealing with inadequate globin chain. In sickle cell, its about abnormal globin chain (one is an issue of quantity the other an issue of quality). Thalassemia and sickle cell are two different disease, hence in genetic inheritance the offspring inherit different disesase. If HbA (beta thalessemia for instance) marries HbAS we have HbS/ß-thalassemia heterozygote: they have some mild degree of sickle cell features (like in sickle cell trait HbAS but this is different from SS. It's rare though and not commonly seen in our part of the world. This Thalassemia is commoner in Mediterranean. The kind you see in Africans won't give you a sickle picture. If AA marries AS they won't have SS (except a lab error if the AA was actually AS). AA is different from A (actually HbA²). |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by sainty2k3(m): 7:50am On Jul 16, 2017 |
[quote author=kindkingsley post=58500317]Please can blood group A+(positive) Father and 0+(positive) Mother give birth to A-(negative) Son blood group? Yes its possible, but maybe not here on this thread, o can do a post on blood group, or you Send me a pm |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by practicalclass: 7:50am On Jul 16, 2017 |
Once you say HbAA, you are saying that qualitatively and quantitatively the Hemoglobin chains are okay. |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by practicalclass: 7:58am On Jul 16, 2017 |
A+ mother marrying O+ father giving birth to A- child is possible if one of the parent is heterozygote or both are i.e Rh+Rh- in one of the parent or both parents. |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by Ghokes(m): 8:03am On Jul 16, 2017 |
Op you have to check your stuffs over again and again. There is a difference between Sickle Cell Disease(common in Sub-Saharan Africa) and Thalassemias(commonly seen in the Mediterranean region including Spain, Portugal, Italy etc). The former has to do with substitution of amino acids while the later has missing amino acids. In fact, from the basic integrated science of JSS 2 couple with AA and AS can never have SS offspring. Go back and dust your book over again and again. |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by litaninja(m): 8:06am On Jul 16, 2017 |
OP.....change the heading oooooooooooooo! |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by korm2me(m): 8:07am On Jul 16, 2017 |
peacettw:Op you see the problem? |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by sainty2k3(m): 8:10am On Jul 16, 2017 |
Ghokes:Thalassemia may be rare here but it does exist, I have sewn and I believe some other people here have seen too. U can't compare basic integrated science to medical knowledge |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by paulverma: 8:15am On Jul 16, 2017 |
anyebedgreat: Abeg which one be AC... My biology teacher need to refund me be that... Shoo. |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by acaolly1(m): 8:17am On Jul 16, 2017 |
dreshemokha: Thank you doctor in the house. Everybody coming up with analysis and mathematical calculations to proof wrong what has been proven over years. Then it is also possible for SS & SS to give birth to AA, Yes spiritually GOD is able to do anything... but medically and mathematically, Biko I no gree |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by Nobody: 8:20am On Jul 16, 2017 |
sainty2k3, I could not go through all 11 pages of this thread but I know have been reminded that an AA and AS couple can NEVER have an SS offspring. It is IMPOSSIBLE Your analogy of thalassemias where the β-thal coexists with the A gene is flawed because the patient's genotype is now Aβ, not AA as you erroneously stated A laboratory could record AA as the genotype, but the patient is actually Aβ. as such an Aβ and AS couple can NEVER have an SS offspring. Exclude clerical errors from the laboratory, that's the source of confusion |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by BABSIN(m): 8:22am On Jul 16, 2017 |
anyebedgreat:This is wrong, check the last two permutations. |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by solepager(m): 8:24am On Jul 16, 2017 |
Hi there, what about AC to AA |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by solepager(m): 8:27am On Jul 16, 2017 |
paulverma: lol...I am AC my broda,,,,there are lot of oda Genotype out there not common. |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by Welcomme: 8:28am On Jul 16, 2017 |
peacettw:Who is castigating who? I am AA and my Bae is AS... I still don't believe this shiit |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by anyebedgreat: 8:31am On Jul 16, 2017 |
BABSIN:C and S gives sickle cell. Likewise Cand C |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by solepager(m): 8:33am On Jul 16, 2017 |
sainty2k3:So are you advising if I should go to a lab I should ask to check my phenotype? and besides why is it not commonly ask? I mean we all grew up and are taught and read about checking genotype between intending couples. And from a lay man, I am still confused? I am AC, if should check my Phenotype would it be different? |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by sgtponzihater1(m): 8:36am On Jul 16, 2017 |
sainty2k3: I pointed out that I saw very few thalassemics, and a dr here with nelsk Monica quickly attacked me that it can't be found in Nigeria, he then came back to ask even though how many, when he found out he was wrong, instead of owning up to his mistake. I already said I saw a few, so why come and ask how many again. Nigerian doctors cause their problems with other health workers, and are still the first to cry foul when the fire ignites. |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by Kennedy767(m): 8:38am On Jul 16, 2017 |
medically op is wrong but if God involves then its possible |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by bigshow123: 8:44am On Jul 16, 2017 |
The doctors on this forum should not unduly dish out half truths or outright lies here. What you people read is about beta thalassemia trait. If a beta Thalassemia trait(AB) marries a sicke carrier (AS), then they can have a child with *Sickle Beta Thalassemia* (SB) which MANIFEST like SS (but it is still NOT SS. Don't confuse people here. |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by sgtponzihater1(m): 8:44am On Jul 16, 2017 |
peacettw: U don't educate someone who is already aware. The Mendelian cross have been taught right from elementary biology. What the caption says is slightly deceptive, AA marrying AS in the true sense of it would not yield SS but for mutation. |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by sgtponzihater1(m): 8:45am On Jul 16, 2017 |
Welcomme: Don't mind the lady |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by reginaldchinna: 8:57am On Jul 16, 2017 |
[quote author=sainty2k3 post=58465800]YES it is not impossible, couples that are AA/AS can give birth to SS , this is how 1. let me differentiate between haemoglobin genotype and haemoglobin phenotype To get a particular GENOTYPE you have to do a genetic testing or use two or more of the screening test (the conventional electrophoresis that we do + HPLC or other similar test) to confirm the true genotype while hb PHENOTYPE is the appearance /characteristics of an individual haemoglobin on conventional electrophoresis which we loosely refer to as GENOTYPE Most times when we call ourselves AA,SS,AS we are actually referring to our Haemoglogin PHENOTYPE and NOT GENOTYPE, as most of us don’t do genetic tests, all we do is haemoglobin electrophoresis 2. lets explain the concept of thalasemic trait. Thalassemias are quantitative defect of haemoglobin which means some one can be AA but the one or both A in this person is is absent otherwise known as thalassemia minor and major respectively. If such person run haemoglobin Electrophoresis( the test that we always loosely regard to as genotype) only A band will be seen and such a person will be regarded as AA. But they are also prone to anaemias and some certain abnormal features in the blood depending on the degree in the reduction in the defective A . such individuals can be Aβ-Thalassaemia(otherwise known as thalassaemic trait) if one of the’ A gene’ is normal, or β-Thalassaemia major if both are affected 3. lets merge the two concepts above and form AND SEE THE DIFFERENT PHENOTYPE THAT EXIST AND THE POSSIBLE CORRESPONDING GENOTYPE If PHENOTYPE is AA the likely GENOTYPES will be AA , Aβ-Thalassaemia If PHENOTYPE is SS the likely GENOTYPES will be SS, Sβ-Thalassaemia (MEANING THE OTHER ‘A’ THAT WOULD HAVE MADE THIS AN ‘AS’ IS TOTALLY ABSENT) Others might include SD,SG etc though these are very rare If PHENOTYPE is AS the likely GENOTYPES will be SA (NOTE – ‘S’ COMES BEFORE ‘A’ BECAUSE THE A IS THALASSAEMIC, THOUGH NOT TOTALLY ABSENT AS THE ONE ABOVE ,IT IS SUSBSTANTIALLY REDUCE), or truely AS 4. Lets assume this our hypothetical couple have Hb eleterophoresis done and was told that the genotype of partner 1 is AA, and that of partner 2 is AS ,but the one that is called AA is actually Aβ-Thalassaemia as ealier mentioned. There possible offspring include I. AA, If the child inherit the normal A from partner 1 and another normal A from partner 2 II. Aβ-Thalassaemia ,If the child inherit β-Thalassaemic A from the partner 1 and normal A from partner 2 III. AS,If the child inherit normal A from partner 1 and S from patner 2 IV. Sβ-Thalassaemia If the child inherit β-Thalassaemic A from partner 1 and S from partner 2 Note that scenario I above will show AA on Hb electrophoresis, scenario ii will show AA on electrophoresis, scenario iii will show AS on electrophoresis and scenario iv will show SS on electrophoresis I have tried to simplify the medical terms but if you still have a doubt or clarification ask and I will try to shed more light, as much as I can. [/quit It impossible because thalassemia and Sickle cell ( plus sickle cell anaemia)are different thing...what explains the never in medicine is mutation which is very rare |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by solution2016: 9:11am On Jul 16, 2017 |
Nothing is impossible in modern technology. After all they used to tell us that mono pause starts from 40, 45 yrs and above. But women these days do conceive even at 55 and above without IVF. |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by Baoo4eva(m): 9:20am On Jul 16, 2017 |
The OP got it completely wrong, I'm a doctor and I'm already deep in my residency program, and I can categorically tell you, its very wrong for you to come up with this theory and also misleading people on an issue that has been a major setback for us. Genotype is the genetic makeup , phenotype is the expression, though phynotypic expression of a gene can be modified by several factors, gene is the most important of them. AS , AA and SS are genes, and the are inherited according to the Mendelian theory ( for the layman), so you can't have a child with SS gene if you don't have the S GENE abnitio. And thalassemic gene is completely different set of genes. |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by jashar(f): 9:34am On Jul 16, 2017 |
NwaAmaikpe: One of the rare times you made sense. |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by makahlj2: 9:37am On Jul 16, 2017 |
As far as I know, Thalassemia and Sickle cell are two unrelated diseases, although their presentations can be similar. |
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