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Nairaland Forum / Nairaland / General / Health / Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' (78115 Views)
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Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by sod09(m): 9:42am On Jul 16, 2017 |
peacettw:you said AA and AC Why u showing AC and AC |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by ozodigboo(m): 9:47am On Jul 16, 2017 |
pls I advise doctors and all other health professionals to ignore the rubbish posted by OP.... This is science...not mathematics. AA marrying AS can never beget SS. |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by peacettw: 10:19am On Jul 16, 2017 |
sod09: That was the only pic I could see online. You can create urs though. |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by sainty2k3(m): 10:21am On Jul 16, 2017 |
noxide:But can have a Sβ. Offspring which HB electrophoresis will show as SS phenotype, but most people don't know that difference between Genotype and phenotype, they just do electrophoresis and assumed that is their genotype |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by sod09(m): 10:26am On Jul 16, 2017 |
peacettw:unless you telling me AC is equal to sickle cell
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Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by sainty2k3(m): 10:30am On Jul 16, 2017 |
ozodigboo:Bring out a science that disprove or keep quiet and stop the insults, be constructive in argument and not abusive, that's the only we to show us how mature and intelligent you are |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by Bondesniger(m): 10:59am On Jul 16, 2017 |
YOU JUST PROVE TO US THAT MOST DRs HAVE TOLD US LIES YOU ARE A GENIUS |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by Defcon1(m): 11:01am On Jul 16, 2017 |
anyebedgreat: Do not always stick to what you know. Always keep an open mind to accept new ideas, and then test them against what you know to see if it's plausible. Only then can you refute the new idea as baseless. That's how you learn. If the ancient scientists stubbornly stuck to the idea of a flat earth, infections being caused by bad air , the earth been the centre of the solar system etc, imagine what would have been. Sainty2k3 put forward a sound scientific argument with available, proven evidence, and you disagreed without any evidence, but what you have always known ?? Well, if you are a healthcare professional you should know there's NO "absolute" or "never" in medicine . This simple maxim is why medicine has evolved, and continues to evolve till this day. |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by buffalowings: 11:02am On Jul 16, 2017 |
12 pages and we still debating. Never heard of this happening Except it is new info |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by eaglechild: 11:31am On Jul 16, 2017 |
jnrremedy:You are confusing yourself and the uninformed public by mixing up different disease entities and phenotype with genotype. Science doesn't need catchy misleading headings to pass its message across. Your heading is a scientific fallacy. 3 Likes |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by Nobody: 11:31am On Jul 16, 2017 |
peacettw: So what u are saying in essence is pple that have been calling themselves AA might actually be carriers..not different from the usual AS. Does it mean that AS too could actually be CS not knowing? If the answer is NO! Please don't tell me dat AA dominant gene could actual have been a misdiagnosed AC due to equipment mumbo jumbo. U ddnt clear any air ooo..i understand that science can be a bit incomplete and not all covering sometimes...but what u are saying now is all the so called AA should not rest their mind anymore cos they might actually be carriers of the sickle cell gene... Later we will soon hear that universal donors O-negatives cannot actually give blood anymore cos there might be an undetected -ve in their blood making them O-positive in reality... There's now explanation to justify all the outcomes of infidelity: dats how two black couple gave birth to a white child..u pple came and justified that she ddnt straff another man that it's possible.... Even DNA profiling, u pple will never give result that will never say 100% match..so at the end of the day all na probability..there's still a little chance left that ur findings are wrong.... |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by peacettw: 11:59am On Jul 16, 2017 |
1StopRudeness: In a nutshell, you are right. Our genotypes might not be what we think it to be. The good thing though is dt this occurs rarely but if it does, we should not all assume that the woman was sleeping around. |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by jnrremedy(m): 12:12pm On Jul 16, 2017 |
noxide:don't give judgment then if u cant read through is not only HbSS that gives sickling condition A thalessemic patient will still present with sickle cell disease similar to sickle cell anaemia and both will give the same result on an electrophoresis tank and the result are both right at that level ( not an error) most Nigerian doctors will not go beyond this test b4 concluding the patient is SS( and is because they don't know). this is the wrong knowledge the op is trying to correct cos cases like this can lead to mistrust and divorce among couples |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by khalids: 12:16pm On Jul 16, 2017 |
Nigerians always talking rubbish....trying to re-invent the wheel......Bros AS + AA will not give SS, no amount of mathematics..... Na so una dey cause confusion like Dino.... With this their nonsense knowledge na so them dey kill people for naija hospital....rubbish |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by jnrremedy(m): 12:19pm On Jul 16, 2017 |
eaglechild:another doctor( I presume ) that don't want to learn sickle cell disease is not only caused by genotype HbSS. the op clearly explained that the SS he qouted on the topic is phenotype not genotype. SS equals sickle cell disease ( as a phenotype) not genotype SS ( most of u ignorantly are quoting). a lot of u guys don't know and u dont want to know |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by femi4: 12:26pm On Jul 16, 2017 |
sainty2k3:Olodo....you still dey argue. Continue to swim in your folly |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by jnrremedy(m): 12:26pm On Jul 16, 2017 |
khalids: most of u that will read will not understand( or not read at all) and u are ignorantly talking as if u know. see u don't know anything genotype HbSS ( the one u know) is different from phenotype SS the one op is saying all HbSS are sucklers but not all sicklers have HbSS. sickle cell disease is different from sickle cell anemia in Nigerian hospitals most doctors erroneously assume all sicklers are of HbSS genotype. this has led to breakups of homes or how will a wife who is AS give birth to a sickler ( with an assumed but false genotype SS that even electrophoresis will confirm)when the husband is AA. u won't understand the details if I should explain (reason u are misquoting the op) but just know that AA/AS couples can still give birth to a sickler and this is not a knew knowledge u just don't know 1 Like |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by femi4: 12:27pm On Jul 16, 2017 |
sod09:You really get time for your hand sha |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by Nobody: 12:29pm On Jul 16, 2017 |
sainty2k3: ![]() ![]() ![]() I maintain that HB electrophoresis is the conventional technique for Hb genotyping all over the world. You seem not to know when screening tests should be indicated. Neither do you know what confirmatory tests are in this case. But, I will gladly help your shallow knowledge. Firstly, you don't confirm a diagnosis using screening test like you are porporting. In a suspected case of SCD based on clinical presentation of a patient, the clinician may requests for some lab tests which I am implicating as screening tests in this case. They may include; - FBC ( full blood count) - Sickling test - PBF ( Peripheral blood film) - ESR (Erythrocyte sedimentation rate) - Bone marrow smear ( rarely done) The judgement of the clinician will be based on the laboratory findings. For instance, if the sickling test is +be and there is presence of target cells & sickled Rbcs in the PBF result & a reduced Hematocrit (PCV) usually <30% in most cases of SCA from the FBC result, this would prompt the clinician to requests for a confirmatory test if he suspects a case of SS/SC from the patient's history. That confirmatory test is Hb electrophoresis. Now, advanced confirmatory techniques for cases of SCD are; - PCR - Isoelectric focusing - HPLC which you mentioned for suspected cases of alpha or Beta thalassamias. Now, the only reason why a clinician will request for confirmation using advanced technique is when the laboratory findings is not in harmony with the clinical findings or expected signs and symptoms of the disease under review. This is where your argument hold waters. That if a patient does not present with clinical manifestation that suit entirely the laboratory findings in a suspected case of SCA (SS). The clinician should not rule out the chances of the patient to be suffering from the thalassamias. Therefore the need for advanced testings aforementioned. I hope you find this submission enlightening and be humble enough to thank me rather than more arguments. |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by anyebedgreat: 12:31pm On Jul 16, 2017 |
Defcon1:It's a scientific argument yes but I can't see any proven or unproven evidence there, maybe you can point it out to me. |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by jnrremedy(m): 12:36pm On Jul 16, 2017 |
femi4: it just amazes me how people flaunt their ignorance rejoicing over their low IQ Why not read learn and engage ur logical reasoning. cos u don't know something does not mean its is false This particular topic has been discussed in clinical meetings of hematology department( where u have prof and consultants of haematology) in uch luth Akure specialist hospital and I was privileged to attend some of them |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by ChelseaDr(m): 12:36pm On Jul 16, 2017 |
barcaboi: Sorry I was actually talking to the Op Thanks Cheers!! |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by MountCliff: 1:09pm On Jul 16, 2017 |
Abstract biology. It is possible for AA and AS couple to produce SS only through gene mutation. |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by olanie(m): 1:17pm On Jul 16, 2017 |
Can't some people disagree honorably whilst staying on point of discourse without being abusive and insultive? |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by ChelseaDr(m): 1:40pm On Jul 16, 2017 |
Protein0: Assuming I understood your question Sir, here is the clarification: Haemoglobin (Hb) is a type of protein composed, structurally, of several amino acids arranged serially to form a chain of amino acids. There are two chains that make up Hb, called the α-chain and the β-chain. In the β-chain, glutamic acid is naturally located at position 6 in the chain of amino acids, to form a normal haemoglobin called HbA. If this glutamic acid is replaced by another amino acid called valine, then Haemoglobin S is formed. If both HbS genes are inherited, then sickle cell anaemia (HbSS) results. If HbA and HbS are inherited a carrier state HbAS results. If the same glutamic acid is replaced by lysine, another amino acid, HbC results, and if HbA and HbC are inherited together then HbAC results, if S and C then HbSC results. HbS and HbC are abnormal haemoglobins, therefore Sickle Cell disease results if an individual inherits an abnormal haemoglobin in the presence of an HbS, e.g. HbSS, HbSC etc. All the above are due to defect in the structure (quality) of haemoglobin not problem of number of amino acids but it has to do with problem od arrangement of those amino acids. Hence, Hb electrophoresis used to determine genotype analyses the structure of these amino acids which makes them possess different speeds as they pass through an electrical field, due to their weight (in a layman's language). Thalasaemias are also forms of abnormal haemoglobin due to lack of production of the appropriate number of chains or lack of production at all. For instance, if there is defect in the production or complete lack of production of the α-chain or β-chain (as the case may be), then α- or β-thalaseamia results. This is as a result of the quantity present or absent. Therefore Hb electrophoresis does not detect Thalasaemias, it can only be detected through procedures that analyse the quantity and type of chains affected (quantitative analysis) I hope I have been able to make some sense to you. Cheers! |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by ChelseaDr(m): 1:42pm On Jul 16, 2017 |
Protein0: Assuming I understood your question Sir, here is the clarification: Haemoglobin (Hb) is a type of protein composed, structurally, of several amino acids arranged serially to form a chain of amino acids. There are two chains that make up normal adult haemoglobin, called the α-chain and the β-chain. In the β-chain, glutamic acid is naturally located at position 6 in the chain of amino acids, to form a normal haemoglobin called HbA. If this glutamic acid is replaced by another amino acid called valine, then Haemoglobin S is formed. If both HbS genes are inherited, then sickle cell anaemia (HbSS) results. If HbA and HbS are inherited a carrier state HbAS results, which is not a form of sickle cell disease. If the same glutamic acid is replaced by lysine, another amino acid, HbC results, and if HbA and HbC are inherited together then HbAC results, if S and C then HbSC results. HbS and HbC are abnormal haemoglobins, therefore Sickle Cell disease results if an individual inherits an abnormal haemoglobin in the presence of an HbS, e.g. HbSS, HbSC etc. All the above are due to defect in the structure (quality) of haemoglobin not problem of number of amino acids but it has to do with problem of arrangement of those amino acids. Hence, Hb electrophoresis used to determine genotype analyses the structure of these amino acids which makes them possess different speeds as they pass through an electrical field, due to their weight (in a layman's language). Thalasaemias are also forms of abnormal haemoglobin due to lack of production of the appropriate number of chains or lack of production at all. For instance, if there is defect in the production or complete lack of production of the α-chain or β-chain (as the case may be), then α- or β-thalaseamia results. This is as a result of the quantity present or absent. Therefore Hb electrophoresis does not detect Thalasaemias, it can only be detected through procedures that analyse the quantity and type of chains affected (quantitative analysis) Sβ-thalasaemia is a form of sickle cell disease due to the presence of both an S haemoglobin and another haemoglobin in which there is shortage in the number of the β-chain. I hope I have been able to make some sense to you. Cheers! |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by ChelseaDr(m): 1:47pm On Jul 16, 2017 |
innosaint27: Thanks a million. I also think the Op should change his topic Cheers!! 1 Like |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by mcPhuture(m): 1:49pm On Jul 16, 2017 |
sainty2k3: Dude, stop scaring people with your crap. For y'all NLanders, it's quite rare and I mean 1 in 50000 cases. More or less like seeing the sun at night time. Dont be scared. Just avoid AS and AS relationships as that's the real threat. Even AA and SS is safe. |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by AlphaT1(m): 1:52pm On Jul 16, 2017 |
ChelseaDr:Oh ok, I got your point. Regards. |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by sainty2k3(m): 1:56pm On Jul 16, 2017 |
innosaint27: You can't be a hematologist , you don't speak like one. There are screening test and diagnostic test, the definitive diagnosis of am Hb Genotype is genetic testing. However , combination of other screening testing might be used to confirm the findings on HB electrophoresis, u see an S only band , you might want to do pbf and sickling test and repeat the electrophoresis in an acidic medium since S,D and G moves together on alkaline medium but differently on acidic medium. HPLC is not only useful in thalassemia ,it can also be a pointer to the presence of some rare HB which might indicate genetic testing. All this tests are used in combination to increase the likelihood of identifying the genotype correctly without genetic testing |
Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' by ChelseaDr(m): 2:00pm On Jul 16, 2017 |
AlphaT1: Thanks again. I also people that are made moderators of a particular section should be individuals who have a good grasp of the subject of discourse, because if this was the case the Mod should have advised the Op to rephrase his topic and possibly remove all forms of ambiguity. I hope Seun will act appropriately. seun |
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