AlphaT1:

Oh ok, I got your point. Regards.

sainty2k3:

Thanks for the additions especially the role of quantitative analysis

For people who want to read this from other sources
https://www.google.com.ng/amp/www.graphic.com.gh/news/health/aa-and-as-partners-produce-ss-baby-is-that-possible.amp.html

BroZuma:
So what happens to those with SS? They should all commit suicide?

Just agree that we have a shameful medical system that is not equipped to handle issues relating to sickle cell.

dreshemokha:
Op. Genetics and health is not mathematics as you just calculated.
And yes it is totally IMPOSSIBLE, a marriage between AA and AS can NEVER produce SS.
Moreover, there is no relationship in inheritance between sickle cell diseases and thalassemias.


Am a doctor with a health blog. Check my signature and visit my blog for robust health info and publications.

NwaAmaikpe:


Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS'

Of course it is possible.

That 'AA' is married to an 'AS' does not mean that
the 'AS' can not shag another 'AS' on the side and bring in a bastard 'SS'

---

Please don't believe this nonsense... Very soon, one confused scientist will bring up a theory claiming it is possible for paternity tests to come back negative when you are truly the father.

sainty2k3:


You can't be a hematologist , you don't speak like one.
There are screening test and diagnostic test, the definitive diagnosis of am Hb Genotype is genetic testing.

However , combination of other screening testing might be used to confirm the findings on HB electrophoresis, u see an S only band , you might want to do pbf and sickling test and repeat the electrophoresis in an acidic medium since S,D and G moves together on alkaline medium but differently on acidic medium. HPLC is not only useful in thalassemia ,it can also be a pointer to the presence of some rare HB which might indicate genetic testing. All this tests are used in combination to increase the likelihood of identifying the genotype correctly without genetic testing

JikanBaura:
What about SC people whom should they marry. I'm AS my Brother Is SC

Bondesniger:
YOU JUST PROVE TO US THAT MOST DRs HAVE TOLD US LIES
YOU ARE A GENIUS

innosaint27:






Oga, i am only trying to help your confused state by explaining things to you on your level. I can only discuss this subject professionally & holistically with a fellow medical practitioner with a mind to learn and expand our horizon on the subject.

It is clear that you are simply confused and not ready to be redeemed from this misleading information you are holding onto tenaciously.

You are not a medical lab scientist nor a pathologist so I can understand why you can't reason on same page with some of us who are medically trained.

I simply don't want to stretch the issue at hand beyond your layman's comprehension.


I assume that, you are an inquisitive person therefore I would recommend that you make out time to read about the thalassamias and compare your findings with that of SCA especially in the area of clinical findings & laboratory diagnosis.


Pls, stop confusing the public. Thalassamias are rare among the black population. Prevalence is high in Asian countries as well as the Middle east. So Nigerians need not worry about the condition. A proper knowledge of it is essential for us especially medical practitioners.

Until you do that, an recalibrate your senses, don't quote me pls.

jnrremedy:

another doctor( I presume ) that don't want to learn
sickle cell disease is not only caused by genotype HbSS. the op clearly explained that the SS he qouted on the topic is phenotype not genotype. SS equals sickle cell disease ( as a phenotype) not genotype SS ( most of u ignorantly are quoting).

a lot of u guys don't know and u dont want to know

sainty2k3:

I can see you have nothing to offer but insult, just don't want you to keep disgracing our profession with this your attitude. Thallasemia are not as rare as we previously thought they are

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2932515/

That's a research by prof shokunbi, Dr Kotila et all.
Now if you are really a hematologist I'm not expecting you to contend the Outcome of their study , except u have a counter study

innosaint27:






Kudos to the researchers for their efforts in trying to shed light on the PREVALENCE OF BETA THALASSAMIA TRAITS in Nigeria.

But, OP did you notice that the research publication was in 2009 and not current?

Did you also notice that, only 50 subjects were enrolled in the study?

Did you notice that, those 50 subjects were all in Ibadan?

Need I remind you that the population of Nigeria is over 170 million and as a result the research finding cannot be said to be significant in the general population. Although the researchers confined their study to south west of Nigeria, Ibadan to be exact.

Moreover, you seem not to have understood the aim of the study. Their aim was to acertain the prevalence of beta thalassamia trait & not the disease itself.

Furthermore, the researchers clearly aligned themselves to all I have been tying to make you understand since yesterday but you simply can't see beyond the misleading knowledge you have sunk yourself into.

Please, go thru the article again and gain some understanding.

All 50 subjects were only screened for Beta thalassamia trait. The result obtained from the research is to determine the prevalence of those with the trait for beta thalassamia and not sufferers of the disease as the disease itself is very rare in this part of the world.


I just don't know why you like confusing yourself.

BTW, what exactly is your discipline? Cos you talking about disgracing OUR PROFESSION got me thinking. Cos if u are anywhere near the medical profession or an allied health professional, your reasoning won't be this vague.

sainty2k3:

You understand nothing about that study , so if the prevalence wasn't rare in 2009, u think it would be rare In 2017. , like I responded to a post by more intellectual fellow, there are researches ongoing which I'm aware of, centered on findind the prevalence of thalassemia using molecular studies, till its published we'll rely on the current knowledge and great contributions from the author of that articlw I quoted earlier.
So do I need to also clarify for you that beta thalassemia trait is the same as A-beta thalassemia which was the main subject of discuss in my post as it is mostly misdiagnosed as AA on our conventional HB electrophoresis

And yes you are disgracing our profession by ignoring a constructive way of argument to be using abusive words and insults, that's not a conduct expected from someone you claimed to be (that's if you are really who you claim to be)

innosaint27:






I maintain that HB electrophoresis is the conventional technique for Hb genotyping all over the world.

You seem not to know when screening tests should be indicated. Neither do you know what confirmatory tests are in this case.

But, I will gladly help your shallow knowledge.

Firstly, you don't confirm a diagnosis using screening test like you are porporting. In a suspected case of SCD based on clinical presentation of a patient, the clinician may requests for some lab tests which I am implicating as screening tests in this case. They may include;

- FBC ( full blood count)
- Sickling test
- PBF ( Peripheral blood film)
- ESR (Erythrocyte sedimentation rate)
- Bone marrow smear ( rarely done)
The judgement of the clinician will be based on the laboratory findings. For instance, if the sickling test is +be and there is presence of target cells & sickled Rbcs in the PBF result & a reduced Hematocrit (PCV) usually <30% in most cases of SCA from the FBC result, this would prompt the clinician to requests for a confirmatory test if he suspects a case of SS/SC from the patient's history. That confirmatory test is Hb electrophoresis.

Now, advanced confirmatory techniques for cases of SCD are;

- PCR
- Isoelectric focusing
- HPLC which you mentioned for suspected cases of alpha or Beta thalassamias.

Now, the only reason why a clinician will request for confirmation using advanced technique is when the laboratory findings is not in harmony with the clinical findings or expected signs and symptoms of the disease under review.

This is where your argument hold waters. That if a patient does not present with clinical manifestation that suit entirely the laboratory findings in a suspected case of SCA (SS). The clinician should not rule out the chances of the patient to be suffering from the thalassamias. Therefore the need for advanced testings aforementioned.

I hope you find this submission enlightening and be humble enough to thank me rather than more arguments.

sainty2k3:

But can have a Sβ. Offspring which HB electrophoresis will show as SS phenotype, but most people don't know that difference between Genotype and phenotype, they just do electrophoresis and assumed that is their genotype

logica:
Example of the miseducation we are talking about. Yes, it is ALWAYS. And you only get a different result when most likely the AA result was actually wrong; rather Aß.

innosaint27:





Hb SC is a variant of Hb SS but they are both sickle cell anaemia.

Your brother can only marry someone who is Hb AA in other to have healthy offsprings.

Marrying someone who is AS, AC, SS, SC is a big No.

Cases of SC are treated same well as SS.


Cheers!

sgtponzihater1:


They are not both sickle cell anaemia, SS is anaemia, HbSC is a type of sickle cell disease.

jnrremedy:

don't give judgment then if u cant read through

is not only HbSS that gives sickling condition
A thalessemic patient will still present with sickle cell disease similar to sickle cell anaemia and both will give the same result on an electrophoresis tank and the result are both right at that level ( not an error) most Nigerian doctors will not go beyond this test b4 concluding the patient is SS( and is because they don't know). this is the wrong knowledge the op is trying to correct cos cases like this can lead to mistrust and divorce among couples

LionDeLeo:
OP, I did not bother to read your analysis because I know you just want to make noise.

What you are saying is the most impossible thing on Earth.

Even AA & SS cannot produce SS, not to talk of AA & AS.

femi4:
That you are sickle cell doesn't mean you are informed

funmisticqueen:
Show refrences, until then your claim doesnt hold water

dreshemokha:
Op. Genetics and health is not mathematics as you just calculated.
And yes it is totally IMPOSSIBLE, a marriage between AA and AS can NEVER produce SS.
Moreover, there is no relationship in inheritance between sickle cell diseases and thalassemias.


Am a doctor with a health blog. Check my signature and visit my blog for robust health info and publications.

tosyne2much:
Madam, I have health complications and I messaged you. Haven't seen your reply

tosyne2much:
Madam, I have health complications and I messaged you. Haven't seen your reply

funmisticqueen:
I didnt see your mail o, i just checked now