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Nairaland Forum / Nairaland / General / Health / New Research Opens The Door To 'functional Cure' For HIV (15024 Views)
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New Research Opens The Door To 'functional Cure' For HIV by Enouwem(m): 9:08pm On Oct 17, 2017 |
![]() The authors of the new study included (left to right): Susana Valente, Cari F. Kessing and Chuan Li. Credit: The Scripps Research Institute In findings that open the door to a completely different approach to curing HIV infections, scientists from the Florida campus of The Scripps Research Institute (TSRI) have for the first time shown that a novel compound effectively suppresses production of the virus in chronically infected cells, and prevents viral rebound, even when those infected cells are subjected to vigorous stimulation. The study, led by TSRI Associate Professor Susana Valente, was published online Oct. 17 before print in the journal Cell Reports. "No other anti-retroviral used in the clinic today is able to completely suppress viral production in infected cells in vivo," Valente said. "When combining this drug with the standard cocktail of anti-retrovirals used to suppress infection in humanized mouse models of HIV-1 infection, our study found a drastic reduction in virus RNA present—it is really the proof-of-concept for a 'functional cure.'" Valente, a pioneer in this new approach, calls it "Block-and-Lock"—the approach blocks reactivation of the virus in cells, even during treatment interruptions, and locks HIV into durable state of latency. Valente and her colleagues use a derivative of a natural compound called didehydro-Cortistatin A (dCA), which blocks replication in HIV-infected cells by inhibiting the viral transcriptional activator, called Tat, halting viral production, reactivation and replenishment of the latent viral reservoir. "Combining dCA with anti-retroviral therapy accelerates HIV-1 suppression and prevents viral rebound after treatment interruption, even during strong cellular activation," Valente said. "It's important to note that our study uses the maximum tolerable dose of the drug—with virtually no side effects." The scientists studied the combination therapy in a mouse model of HIV latency and persistence. Once the combined treatment regimen was halted, viral rebound was delayed up to 19 days, compared with just seven days in mouse models receiving only anti-retroviral treatment. "This demonstrates the potential of 'block-and-lock' strategies," said TSRI Research Associate Cari F. Kessing, co-first author of the study. "This study shows that a 'functional cure' approach can succeed in reducing residual virus in the blood during anti-retroviral treatment and limiting viral rebound during treatment interruption." "In half of the dCA treated mice, the virus was undetectable for 16 days after all treatment was halted," said the University of North Carolina's Christopher Nixon, another first author. "We blocked Tat, and the cell's machinery did the rest," said TSRI Research Associate Chuan Li, a coauthor of the study. "The result was that the HIV promoter becomes repressed." Valente pointed out that the animal models were exposed to just a single month of treatment. "That's a relatively short period of time," she said. "We think longer treatments will result in longer, or even permanent, rebound delays. The question is how long? We're studying that now." Because any viral rebound of HIV comes with a host of adverse effects, Valente noted, blocking that rebound would automatically reduce those effects. "This is the only class of drugs that stops infected cells from making viruses outright," said Valente. "All current antivirals work later in the viral lifecycle, so only a HIV transcriptional inhibitor like dCA can stop the side effects of low-level virus production." In addition to Valente, Kessing, Li and Nixon, other authors of the study, "In Vivo Suppression Of HIV Rebound By Didehydro-1 Cortistatin A, A 'Block-And-Lock' Strategy For HIV-1 Treatment," are Guillaume Mousseau and Mohammad Fallahi of TSRI; Perry M. Tsai, Phong T. Ho, Jenna B. Honeycutt and J. Victor Garcia of the University of North Carolina; and Hiroshi Takata and Lydie Trautmann of Walter Reed Army Institute of Research and the Henry M. Jackson Foundation for the Advancement of Military Medicine. Source: https://m.medicalxpress.com/news/2017-10-door-functional-hiv.html Lalasticlala 3 Likes 2 Shares |
Re: New Research Opens The Door To 'functional Cure' For HIV by Kimy97(f): 9:56am On Oct 18, 2017 |
Hmmmm..good...Ftc Tinx 1 Like |
Re: New Research Opens The Door To 'functional Cure' For HIV by Ihatepork: 9:56am On Oct 18, 2017 |
good |
Re: New Research Opens The Door To 'functional Cure' For HIV by JoshMedia: 9:56am On Oct 18, 2017 |
Nice one Hope it turns to be successful. Check my signature |
Re: New Research Opens The Door To 'functional Cure' For HIV by dycbk: 9:56am On Oct 18, 2017 |
FTC YAHHO |
Re: New Research Opens The Door To 'functional Cure' For HIV by BornnAgainChild(f): 9:56am On Oct 18, 2017 |
Ok good...but what about monkey pox 3 Likes |
Re: New Research Opens The Door To 'functional Cure' For HIV by Celcius: 9:56am On Oct 18, 2017 |
We hope for a final cure. A longer time for the Virus to stay repressed is a welcome development. 2 Likes |
Re: New Research Opens The Door To 'functional Cure' For HIV by donblade85555(m): 9:57am On Oct 18, 2017 |
Since they gave birth to me that they being researching about this HIV....there already have the cure but they want us to keep eating money on that their HIV control drug. anyway for funny jokes and riddles that will make you laugh like a mad man visit www.laughkillme.com 1 Like |
Re: New Research Opens The Door To 'functional Cure' For HIV by ivolt: 9:57am On Oct 18, 2017 |
This isn't a cure per se, just an improvement on existing ARVs. 3 Likes |
Re: New Research Opens The Door To 'functional Cure' For HIV by Hawlahscho(m): 9:58am On Oct 18, 2017 |
Re: New Research Opens The Door To 'functional Cure' For HIV by stcool(m): 9:58am On Oct 18, 2017 |
mccoy47: You need Jesus! 10 Likes 1 Share |
Re: New Research Opens The Door To 'functional Cure' For HIV by saint047(m): 9:58am On Oct 18, 2017 |
Ok |
Re: New Research Opens The Door To 'functional Cure' For HIV by Nobody: 9:59am On Oct 18, 2017 |
Good development |
Re: New Research Opens The Door To 'functional Cure' For HIV by kagari: 9:59am On Oct 18, 2017 |
Re: New Research Opens The Door To 'functional Cure' For HIV by courna(m): 10:00am On Oct 18, 2017 |
OK..we don hear |
Re: New Research Opens The Door To 'functional Cure' For HIV by Emeka71(m): 10:00am On Oct 18, 2017 |
Hawlahscho:For sale? |
Re: New Research Opens The Door To 'functional Cure' For HIV by samskin(m): 10:01am On Oct 18, 2017 |
if they happen to find the cure for HIV and cancer God the earth will be worst than hell. it will fast forward the coming of our creator.. ashawo go they bleep nonsense comut from man dvck. |
Re: New Research Opens The Door To 'functional Cure' For HIV by iamchybs(m): 10:01am On Oct 18, 2017 |
Re: New Research Opens The Door To 'functional Cure' For HIV by gebest: 10:02am On Oct 18, 2017 |
all those na stories, what everybody want to hear is "we don see the cure period" |
Re: New Research Opens The Door To 'functional Cure' For HIV by DirtyGold: 10:02am On Oct 18, 2017 |
Another improvement. Good but HIV still remains the disease to avoid. The Pharm industry has not made enough money from HIV yet and there's no sustainable product replacement for the money-spinner ARVs Be wise, play safe. What's tha business? |
Re: New Research Opens The Door To 'functional Cure' For HIV by musicwriter(m): 10:02am On Oct 18, 2017 |
The body's immune system has already defeated the HIV/AIDS virus, making it powerless even if you have it. The body was designed to work that way from creation. The body always adapt and eventually find a way to get around such situation and has been doing so for millions of years. That's why the human race has been able to survive for millions of years when there were no drugs at all. If such healing power didn't naturally exist, the human race would have gone extinct many years ago. Western pharmaceutical companies are about to pull something big. Just watch out. 1 Like |
Re: New Research Opens The Door To 'functional Cure' For HIV by Slayer2: 10:04am On Oct 18, 2017 |
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Re: New Research Opens The Door To 'functional Cure' For HIV by maxiuc(m): 10:09am On Oct 18, 2017 |
Nigga raw and Mr Rawbison Good news but that shouldn't make me to jump into any well or carnal because I want pleasure |
Re: New Research Opens The Door To 'functional Cure' For HIV by oshe11: 10:10am On Oct 18, 2017 |
Them never hide the cure reach ![]() HIV WHEN PEOPLE DON EVEN FORGET..... THEY JUST WANNA MAKE IT RELEVANT AGAIN ![]() |
Re: New Research Opens The Door To 'functional Cure' For HIV by Soulsymbol99: 10:12am On Oct 18, 2017 |
There can never be a cure, u know why? Cause the moment they release the cure and you can jst walk into a pharmacy n buy d drug watch how the population of the world is goin to sky rocket ![]() ![]() 3 Likes |
Re: New Research Opens The Door To 'functional Cure' For HIV by okerekeikpo: 10:13am On Oct 18, 2017 |
How many times una go bring out the medicine sef? Everytime u guys keep talking trash |
Re: New Research Opens The Door To 'functional Cure' For HIV by omojeesu(m): 10:13am On Oct 18, 2017 |
Good. |
Re: New Research Opens The Door To 'functional Cure' For HIV by ChangetheChange: 10:13am On Oct 18, 2017 |
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Re: New Research Opens The Door To 'functional Cure' For HIV by johncreek: 10:13am On Oct 18, 2017 |
Re: New Research Opens The Door To 'functional Cure' For HIV by Alexbond(m): 10:17am On Oct 18, 2017 |
hmmmm....I thought, there was a news on nairaland months back, claiming a Nigerian has found the remedy to HIVS? Anyways, It seems no medical discovery can be acknowledged in curing of HIVS if it's not coming from the States...It's good they have finally found one. I hope UN/WHO would help to subsidise the drug when it is finally produced for the poor HIV syndrome carriers. |
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