Venetoclax, a BH3-mimetic, has been recently approved for the treatment of AML and induces apoptosis by blocking the anti-apoptotic B-cell lymphoma-2 (Bcl-2) protein.
Preclinical data has shown the anti-leukemic efficacy of venetoclax in AML, especially when combined with hypomethylating agents or chemotherapy agents, demonstrating synergy.
Clinical trials have highlighted the clinical benefit of venetoclax-based therapies in newly diagnosed AML patients, leading to FDA approval for its use in combination with hypomethylating agents or low-dose cytarabine in older adults with newly diagnosed AML.
Venetoclax has shown promising results in elderly AML patients who are unfit for standard induction chemotherapy, achieving a 67% complete response rate with a median overall survival of 17.5 months when combined with a hypomethylating agent.
Despite upfront resistance and relapse following complete response, ongoing research aims to understand the mechanisms of sensitivity and resistance to venetoclax in AML cells to develop successful combination therapies that eradicate minimal residual disease (MRD).
Venetoclax is metabolized by CYP3A4/5 and should not be taken with grapefruit products or other drugs containing CYP3A inhibitors to avoid adverse interactions.
Reference Page: https://medsforcancer.com/product/ventoxen-100mg-venetoclax/

Hello My Friend,

Yes, Acute Myeloid Leukemia (AML) treatment via stem cell therapy, also known as a stem cell transplant or bone marrow transplant, is a complex process aimed at replacing damaged or diseased bone marrow with healthy stem cells. Here's how the treatment generally works:

Treatment Process:

1. Initial Diagnosis and Evaluation
2. Stem Cell Collection
3. Conditioning Treatment
4. Stem Cell Infusion
5. Engraftment and Recovery
6. Post-Transplant Care

In conclusion, stem cell therapy for AML is a rigorous and potentially life-saving treatment option that involves replacing diseased bone marrow with healthy stem cells. While it offers significant benefits, it also comes with considerable risks and requires careful consideration and close medical supervision.