Docs in the house kudos to u. Pls I want u to explain more on genotype SC, I am one and never spend 24 hrs in the clinic before. Infact got to know of the genotype @ 17 while seeking admission.

fatymore:
AS

I'm AA can we now be friends?

One of the best things i've ever read on nairaland. Kudos to you all who made it possible. Quite educative.

lepasharon:


because you are AC and you shouldnt have any clinical symptoms because of ur hemoglobin

Not having clinical symptoms doesn't portend that all is well
The fact that some amino chains are misplaced means there must be repercussions.
There might be impairment in the way that the blood carries oxygen and nutrients around the body. And also the possibility of quick breakdown and degeneration of the blood cells than a normal AA
Hence there must be precautions and advises that would make things better

Dexema:


Correct me but I don't think your calculation is correct. Rather, for every birth, an AS+AS couple has a 25% chance of birthing an SS child.
My advice: For any that can produce SS kindly be mature and refrain from such relationship.

what about a relationship that can produce SC

tomdon:



Not having clinical symptoms doesn't portend that all is well
The fact that some amino chains are misplaced means there must be repercussions.
There might be impairment in the way that the blood carries oxygen and nutrients around the body. And also the possibility of quick breakdown and degeneration of the blood cells than a normal AA
Hence there must be precautions and advises that would make things better

ok do you suffer from any of those things

Lanceslot:
I'm AA can we now be friends?

yed

Feb, u have done a great job here! Long life to you so that you can do more and save life

blueskies:


I'm also AA, my sis is AS n she hardly falls ill with malaria, typhoid, headaches, unlike me. I use blood tonic often. Does dis happen, I mean AS rarely falling ill while its smtyms frequent with AA... ?

partially right
the S haemoglobin trait is a natural adaptation of the body to malaria attacks. The reason S trait is more prevalent here in the malaria endemic sub Saharan Africa.
blood cells with the S hemoglobin chain gets destroyed early by the spleen hereby destroying any malaria parasites in the red blood cells before they complete their life cycle ( malaria parasites develop in d red blood cells)
so someone with genotype AS will have some level of immunity against malaria compared to genotype AA. but note that there are other factors responsible for malaria attacks. Genotype is not enough to confer full immunity to malaria ( although it can confer some level of immunity)

I believe its high time we began to also raise the awareness for beta thalassemia.( one of the other numerous thalassemia disease mentioned earlier by fsb)
although its not as prevalent as sickle cell disease it is also caused by two carriers ignorantly marrying each other

its not only genotype that guarantees not giving birth to a sickler it's very possible for AA couples to give birth to a sickler. it has happened a lot of times here in Nigeria.

Abiagirl777:



biko ,don't put head there for the sake of your unborn children and your future peace.my neighbours are both as and have had 5 children with 3being sicklers (as).before they relocated they buried 2 below 5 yrs respectively,while the other is being rushed to the hospital biweekly.
pls think it well.the crossing of 2 As will produce an AA(normal),2 AS(carriers) and 1 ss(suckler).1 in 4 of your children will be a sickler.

Not necessarily true but rather,there's a 1in 4 chance or 25% chance of getting a sickler (Hb SS) in every conception. So it is still possible to have all the kids as sicklers, it is also possible to have kids with normal HbAA.

napa:
Please is there any thing like genotype AC

I have genotype AC....its not a myth

Emmion:
@ Skillmyman,

I really appreciate the piece of info. But i thought CC genotype is the equivalent of SS like i was told. Wont a child with CC genotype be a sickler?

it's not an equivalent. risky tho but never like SC or SS

....

....

Good day doctors in the house, Pls I need clarification on this. Is it possible for a childs genotype and blood group not to match with d father. The fathers genotype is AA and blood group O+ while that of d child is B+ and genotype AC

Topisyn:
Good day doctors in the house, Pls I need clarification on this. Is it possible for a childs genotype and blood group not to match with d father. The fathers genotype is AA and blood group O+ while that of d child is B+ and genotype AC

What is your wife's blood group and genotype?

WRVUK:
I got an amazing result that i am CC and my girlfriend is AS. pls someone tell me if we are compatible. i am really worried

What is CC? Why didn't you ask them to explain it to you, where you did the test?

Neddyogu:
Not necessarily true but rather,there's a 1 in 4 chance or 25% chance of getting a sickler (Hb SS) in every conception. So it is still possible to have all the kids as sicklers, it is also possible to have kids with normal HbAA.

Thank you, o! Whenever I try to explain the possibility of such outcomes to those carrying the sickle-cell trait, they look at me as if i am an alien from outer space. One actually called me a 'killjoy. Can you imagine??!

Emmahunk:
ABC OF GENOTYPE
..
Genotype & It's Appropriate Suitor:
AA + AA = Excellent
AA + AS = Good
AA + SS = Fair
AS + AS = Bad
AS + SS = Very Bad
SS + SS = Extremely Bad (In fact, don't try it)
#SickleCellAwareness

In fact, AS + AS means the witches from your respective villages, have started manipulating your destiny. You can still backtrack from a proposed union, or make sure you have millions to conduct pre-implantation genetic diagnosis for sickle-cell anemia on any pregnancy, that occurs. You also need to keep millions on hand, to facilitate a successful IVF using ICSI or any other procedure, to achieve a successful pregnancy, that results in an embryo free of the SS gene. AS +SS or SS+SS means those witches in the village, have already concluded your case. No appeal....

what if AC marries AC

chorlay:
what if AC marries AC

AA, AC, CC OUTCOMES

youseuph:

You not totally correct. CC is not a very serious medical condition as you put it. I rep CC genotype and am as fit as fiddle, though with occasional jaundice.

How do you treat the Occasional jaundice ? I'm AC and hardly fall sick asides constant pain in the chest region.

AC is normal but susceptible, SC has mild anemia and CC is normal and resistant to malaria. The following approximate fitnesses have been assigned to these genotypes...
If you want to know more about genotype AC, please visit the page for answer: genotyping by sequencing.

kikogarcia:
AC is normal but susceptible, SC has mild anemia and CC is normal and resistant to malaria. The following approximate fitnesses have been assigned to these genotypes...
If you want to know more about genotype AC, please visit the page for answer: genotyping by sequencing.

When you say AC is susceptible, what do you mean
Kindly explain.

I am ready to meet my Maker. Whether my Maker is prepared for the great ordeal of meeting me is another matter.

I recently met an AC person.
The genotype thing should be written on our faces oh before someone starts catching unnecessary feelings.

The knowledge of hemoglobin genotype is relevant when choosing a life partner to avoid compatibility issues that may result in devastating effects relating to conception. This is why it is essential to ask questions such as how many types of genotype are there and what is their compatibility.

People with sickle cells experience episodes of severe pains in body parts where oxygen flow is compromised because of blockage in the blood vessels. People with genotype AA are safe to marry individuals with any of the others. AS is compatible with AA, AS, and AS, AS and AC are too risky since two sickle cells should avoid conception. Below is a comprehensive compatibility chart:

AA + AA = AA, AA, AA, AA (Excellent)

AA + AS = AA, AS, AA, AS, (Good)

AA + SS = AS, AS, AS, AS, (Fair)

AA + AC = AA, AA, AA, AC. (Good)

AS + AS = AA, AS, AS, SS, (Very Bad)

AS + SS = AS, SS, SS, SS, (Very Bad)

AS + AC = AA, AC, AS,SS. (Bad; Advice needed)

SS + SS = SS, SS, SS, SS, (Very Bad)

AC + SS = AS, AS, SS, SS, (Very Bad)

AC + AC = AA, AC, AC, SS. ( Bad; Advice needed)

Difference between genotype and phenotype
Even though the two might sound the same and are related, they mean different things. While genotype refers to the set of genes in the DNA of an organism responsible for a particular trait, on the other hand,phenotype,is described as the physical expression, or characteristics of that trait. Phenotypes can be determined just by observing things such as height, hair color, and eye color, and so on.