The blessings that can be regarded as irreversible are those which come from God. God Almighty decided to give irreversible blessings to Abraham. In Genesis 22:16-17, God declared thus:
“...By myself have I sworn, saith the LORD, for because thou hast done this thing, and hast not withheld thy son, thine only son: That in blessing I will bless thee, and in multiplying I will multiply thy seed as the stars of the heaven, and as the sand which is upon the sea shore; and thy seed shall possess the gate of his enemies;”
 
The conditional nature of divine blessings makes some of them irreversible. When you fulfil some spiritual conditions for divine blessings, God will show Himself mighty, faithful and dependable in your life. Nobody is able to reverse a divine blessing, except God Himself. He will only reverse it if the recipient defaults in the terms of His covenant. For example, God reversed the promise He made to Eli when he and his sons failed to live by the terms of the covenant that made them God’s priests (1 Samuel 2:30). If God decides to bless you and you mess up, He can change a blessing to a curse.
 
The faithfulness of God in keeping His promise to Abraham is demonstrated in Genesis 26, while the irreversible nature of this promise is demonstrated in Genesis 35. In these two instances, the Almighty God reiterated to Isaac and Jacob that the promise He made to Abraham was an everlasting covenant.
 
Before a person can enjoy irreversible blessings, there are certain conditions he or she must fulfil in Jesus Christ. These include remarkable love towards God, sacrificial giving and commitment to holiness and worship. All these attributes are found in Jesus Christ, and they can rub off on anyone who accepts him as Lord and Personal Saviour. The Bible in Colossians 1:19-20 says:
“For it pleased the Father that in him should all fulness dwell; And, having made peace through the blood of his cross, by him to reconcile all things unto himself; by him, I say, whether they be things in earth, or things in heaven.”
To enjoy irreversible blessings therefore, you must establish a lasting relationship with the Almighty Father, from whom all blessings flow, through Jesus Christ.