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Help! His Genotype Is AA And His Wife's Genotype Is AS But Their Daughter is SS - Health (9) - Nairaland

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Re: Help! His Genotype Is AA And His Wife's Genotype Is AS But Their Daughter is SS by Jonwesley(m): 1:39pm On May 12, 2015
Mendel genetic laws remain sacrosanct on issues concerning genotype of offspring.

I rather suspect that the father may not be able to impregnate his wife. Why the so much gap? Ten years marriage, and this is the first child. The further tests should include the husband's sperm count.

Probably the wife knew this situation and to cover her shame tricked a family blood line with a coincidental DNA as the husband to play away match or adultery.

If the sperm count test shows that the husband is infertile then they should look no further but for the woman to confess. This is my digression on what possibility there is to this puzzle.
Re: Help! His Genotype Is AA And His Wife's Genotype Is AS But Their Daughter is SS by Omotayor123(f): 1:41pm On May 12, 2015
Medical Experts advising As to Marry AA doesn't guarantee they won't have SS offspring. It's Just a precautionary movite to have lesser SS in d Society.

Don't ask me Why But You can ask God how he does his Wonders.




.Plus....

It is Stupid & Heartless for dat Man to want a divorce after confirming d Child is his Blood....

1 Like

Re: Help! His Genotype Is AA And His Wife's Genotype Is AS But Their Daughter is SS by FactorVIII: 1:42pm On May 12, 2015
1. @Demichaels pls tell your friend to ask his doctor to check him for alpha thalassemia
2. I am almost certain he has that.
3. alpha + thalassemia is usually harmless, it is caused by alpha gene deletions or in some cases dysfunctional alpha gene. However, people (the child in this case ) who inherit combinations of hb S (ie from the mother in this case ) may have hemoglobin disorder.
4. Hemoglobin electrophoresis is normal, DNA analysis is needed to be certain
5. Since a paternity test has been done here, infidelity resulting to the birth of the child can be safely ruled out.
6. This is simple Hematology.
7. Pls go to Hematology department LUTH to confirm, you will meet my professors and doctors, they are nice people
8. @ some nairaland peeps. pls if you are not enlightened on a particular subject, pls read abt it instead of judging people and using words like "impossible"
9. I really hope you see this. it can save your friend's marriage.

4 Likes

Re: Help! His Genotype Is AA And His Wife's Genotype Is AS But Their Daughter is SS by Omotayor123(f): 1:43pm On May 12, 2015
Jonwesley:
Mendel genetic laws remain sacrosanct on issues concerning genotype of offspring.

I rather suspect that the father may not be able to impregnate his wife. Why the so much gap? Ten years marriage, and this is the first child. The further tests should include the husband's sperm count.

Probably the wife knew this situation and to cover her shame tricked a family blood line with a coincidental DNA as the husband to play away match or adultery.

If the sperm count test shows that the husband is infertile then they should look no further but for the woman to confess. This is my digression on what possibility there is to this puzzle.
You speak Wisdom #
Re: Help! His Genotype Is AA And His Wife's Genotype Is AS But Their Daughter is SS by Nobody: 1:48pm On May 12, 2015
bettercreature:
Oyin sweetie,the guy wrote us here in 2013 that he was having issues with his SS girl friend, and later wrote on here today that he has the same problem of given birth to SS baby..



oki, free him
Re: Help! His Genotype Is AA And His Wife's Genotype Is AS But Their Daughter is SS by Ifebazz(m): 1:48pm On May 12, 2015
tpiadotcom:


then he should accept the results and stop broadcasting everywhere.

is he trying to avoid caring for the child because of the SS status?
Not broadcasting, he's trying to make sure there was no foul play. Very natural.
Re: Help! His Genotype Is AA And His Wife's Genotype Is AS But Their Daughter is SS by Kcinho(m): 1:50pm On May 12, 2015
Demichaels:

They have done that severally
by severally you mean differently
Re: Help! His Genotype Is AA And His Wife's Genotype Is AS But Their Daughter is SS by wheezyoung(m): 1:51pm On May 12, 2015
Demichaels:


Yes. The wife inclusive
you as the man's friend should have a talk,man to man about the ladies he has sleep with, this could be a genetic problem or it could be spritual,this is Nigeria,where witches and wizards are at work the most.....considering the fact that it took them 6 years to get a child,i believe there's something behind it as long as both parties abstained from infidelity
Re: Help! His Genotype Is AA And His Wife's Genotype Is AS But Their Daughter is SS by FactorVIII: 1:52pm On May 12, 2015
Demichaels:
My friend's 10 year Marriage is about to collapse.

His, my friend's genotype is AA and his wife's genotype is AS but their 4 year old daughter has been confirmed to have SS genotype by not less than 4 different medical experts. He confronted the wife and accused her of infidelity but she vehemently denied having any affair with another man. In other to prove her wrong, my friend subjected the little girl to a paternity test and there he got the shock of his life - the result showed he actually is the father of the girl. At first he accused the doctor of compromise because he is their family doctor and somehow relates to the wife. He then decided to go to another hospital to prove the paternity of the girl child there and then he got another shocker - the first result was actually correct. As It stands, my friend has consulted more than five other doctors outside the state of his residence and all Confirmed that the girl's genotype is SS and he actually is the father of the child despite his and the wife's genotype being as stated above. Even the doctor's are confused by the results as it negate conventional medical norm.

My question now is, experts in the house, is there anything that can lead to such unconventional biological flaw? Under what condition can AS and AA couple have an SS child? Can mutation lead to such condition? My friend insists on divorce because he doesn't believe the wife. Should he go ahead based on what we all know about genotype?


Please I need matured advice on this. This is a REAL LIFE SITUATION AND NO FICTION. I WOULD HAVE MENTIONED NAMES AND ADDRESS OF THE COUPLE BUT I DON'T HAVE THEIR PERMISSION YET. THIS IS HAPPENING RIGHT HERE IN PORT HARCOURT OLD GRA WE'RE LIVING
1. @Demichaels pls tell your friend to ask his
doctor to check him for alpha thalassemia
2. I am almost certain he has that.
3. alpha + thalassemia is usually harmless, it is
caused by alpha gene deletions or in some
cases dysfunctional alpha gene. However,
people (the child in this case ) who inherit
combinations of hb S (ie from the mother in this
case ) may have hemoglobin disorder.
4. Hemoglobin electrophoresis is normal, DNA
analysis is needed to be certain
5. Since a paternity test has been done here,
infidelity resulting to the birth of the child can
be safely ruled out.
6. This is simple Hematology.
7. Pls go to Hematology department LUTH to
confirm, you will meet my professors and
doctors, they are nice people
8. @ some nairaland peeps. pls if you are not
enlightened on a particular subject, pls read abt
it instead of judging people and using words
like "impossible"
9. I really hope you see this. it can save your
friend's marriage.

3 Likes

Re: Help! His Genotype Is AA And His Wife's Genotype Is AS But Their Daughter is SS by SIRICE(m): 1:57pm On May 12, 2015
Elslim:
are u sure he daughter is yours??
like he went in with an ss and the two women happened to give birth same day same hospital, then the nurses mistakenly swapped babies?
Re: Help! His Genotype Is AA And His Wife's Genotype Is AS But Their Daughter is SS by fpeter(f): 1:58pm On May 12, 2015
nanauju:
Make dey ask dat woman question. Or they should both go for a recheck

To think this is coming from a woman...women will always be the ones to victimize their kind and cast aspersions on their
gender.

3 Likes

Re: Help! His Genotype Is AA And His Wife's Genotype Is AS But Their Daughter is SS by aderonila18: 1:59pm On May 12, 2015
I have had incidences where Nigerian labs will call SC -SS and vice versa, it's like they are not used to the variant

Let the man and the daughter be checked at Me- cure. The man may actually be AC and the daughter SC which is possible

4 Likes

Re: Help! His Genotype Is AA And His Wife's Genotype Is AS But Their Daughter is SS by Geesanni: 1:59pm On May 12, 2015
technically looking at ur situation,since d wife is d aa,there is no way she cheated cos d child isnt carrying any of her genotype.assuming u re d aa,then confusion is somewhere.she might still b as not aa,but if more test confirmed that she is aa,then she has a trace of 's' genotype in her lineage which sometime mk one to have of baby of a different gene sth,it happens once in a while.to confirm this, u can test some of her grand-family(her father's/mother's brothers or sisters) if still available to knw if dey are carrier of 's' genotype,if yes she has a recessive of s,which means shehas a chance of having s- child jst like albinos.
funshiba:


Hmmmm.... I got scared when i saw this post.... Its with heavy heart I say this is happening in my young marriage....My spouse is AA im AS. We had our baby in America this year they told us this, We asked for a recheck and it was almost same thing.

We decided to come to run our test in Nigeria, A test and a re-run says the same SS. The hospital advised we check again in few months as the infants undergo changes and the result cannot be confirmed.

We will wait till she is 6 months to 1yr old. But you dont have an idea of how scared i'm. I discussed with a medical consultant friend and he told me it is impossible that I should worry and check when she is one. but I'm scared to death and pray about this everyday. Medicine is abit funny cos I dont know possible this is medically and I dont want my only kid to be an example of such. Pray for us. Its not a good thing to happen.

Note that we are 100% sure of our status and had several rerun of test, I also trust my spouse with all my heart, Besides she is the AA.

I will advice this family that made the post to wait and not scatter the home cos of this. Accusation isnt the best and the wrongest approach to go about it.

Thanks
Re: Help! His Genotype Is AA And His Wife's Genotype Is AS But Their Daughter is SS by fpeter(f): 2:00pm On May 12, 2015
FactorVIII:

1. @Demichaels pls tell your friend to ask his
doctor to check him for alpha thalassemia
2. I am almost certain he has that.
3. alpha + thalassemia is usually harmless, it is
caused by alpha gene deletions or in some
cases dysfunctional alpha gene. However,
people (the child in this case ) who inherit
combinations of hb S (ie from the mother in this
case ) may have hemoglobin disorder.
4. Hemoglobin electrophoresis is normal, DNA
analysis is needed to be certain
5. Since a paternity test has been done here,
infidelity resulting to the birth of the child can
be safely ruled out.
6. This is simple Hematology.
7. Pls go to Hematology department LUTH to
confirm, you will meet my professors and
doctors, they are nice people
8. @ some nairaland peeps. pls if you are not
enlightened on a particular subject, pls read abt
it instead of judging people and using words
like "impossible"
9. I really hope you see this. it can save your
friend's marriage.


8. @ some nairaland peeps. pls if you are not
enlightened on a particular subject, pls read abt
it instead of judging people and using words
like "impossible"


well said...i hope they'll learn.

1 Like

Re: Help! His Genotype Is AA And His Wife's Genotype Is AS But Their Daughter is SS by GodMode: 2:01pm On May 12, 2015
Omotayor123:
Medical Experts advising As to Marry AA doesn't guarantee they won't have SS offspring. It's Just a precautionary movite to have lesser SS in d Society.

Don't ask me Why But You can ask God how he does his Wonders.




.Plus....

It is Stupid & Heartless for dat Man to want a divorce after confirming d Child is his Blood....

Demichaels

It is impossible for AA and AS to birth SS...

The father of the child can be the husband's brother, dad, uncle or cousin because they all share the same genes...
Re: Help! His Genotype Is AA And His Wife's Genotype Is AS But Their Daughter is SS by Elslim: 2:05pm On May 12, 2015
SIRICE:

like he went in with an ss and the two women happened to give birth same day same hospital, then the nurses mistakenly swapped babies?
or he is simply not d father of d baby
Re: Help! His Genotype Is AA And His Wife's Genotype Is AS But Their Daughter is SS by aderonila18: 2:06pm On May 12, 2015
funshiba:


Hmmmm.... I got scared when i saw this post.... Its with heavy heart I say this is happening in my young marriage....My spouse is AA im AS. We had our baby in America this year they told us this, We asked for a recheck and it was almost same thing.

We decided to come to run our test in Nigeria, A test and a re-run says the same SS. The hospital advised we check again in few months as the infants undergo changes and the result cannot be confirmed.

We will wait till she is 6 months to 1yr old. But you dont have an idea of how scared i'm. I discussed with a medical consultant friend and he told me it is impossible that I should worry and check when she is one. but I'm scared to death and pray about this everyday. Medicine is abit funny cos I dont know possible this is medically and I dont want my only kid to be an example of such. Pray for us. Its not a good thing to happen.

Note that we are 100% sure of our status and had several rerun of test, I also trust my spouse with all my heart, Besides she is the AA.

I will advice this family that made the post to wait and not scatter the home cos of this. Accusation isnt the best and the wrongest approach to go about it.

Thanks

As long as your wife is confirmed to be AA even if she cheated the child should be AS as the child must take one from both biological parents. So definitely your wife didn't cheat and there must be another reason
Re: Help! His Genotype Is AA And His Wife's Genotype Is AS But Their Daughter is SS by JideTheBlogger(m): 2:08pm On May 12, 2015
Chai, diaris god oo
Re: Help! His Genotype Is AA And His Wife's Genotype Is AS But Their Daughter is SS by SIRICE(m): 2:11pm On May 12, 2015
Elslim:

or he is simply not d father of d baby
yes maybe his brother
Re: Help! His Genotype Is AA And His Wife's Genotype Is AS But Their Daughter is SS by chizzy86(f): 2:12pm On May 12, 2015
Its very easy to point fingers and talk against people. Some even suggested outright divorce. From what I read, the man is the girl's father. I guess some people jumped that or didn't read the story at all. Pls sir, tell your friend he shouldn't be fast to judge his wife. Some people here have given real life instances to show that it happens in rare cases. I believe science has gone further than the old AA AS stuff. The man should go to specialists to tell him why such a thing happened and stop pointing fingers at his wife.

2 Likes

Re: Help! His Genotype Is AA And His Wife's Genotype Is AS But Their Daughter is SS by rattlesnake(m): 2:12pm On May 12, 2015
Behira:
yea it can but the possibility is very slim
I need to check your genotype
Re: Help! His Genotype Is AA And His Wife's Genotype Is AS But Their Daughter is SS by Charly68: 2:13pm On May 12, 2015
It was a magical reproduction a normally or what ? Et them take the child for deliverance,God knows how to rectify Demonic Confussion.
Re: Help! His Genotype Is AA And His Wife's Genotype Is AS But Their Daughter is SS by Flye: 2:16pm On May 12, 2015
tpiadotcom:


only if a spiritual husband practiced unsafe sex, or else if the child was procured from a baby farm.


In addition, there's a blood type called AC which also passes on sickle cell (SC).


http://sicklecellna.org/faq.html

That is actually what I want to suggest to the guy, AC is between AA and AS and this can produce As/ss

1 Like

Re: Help! His Genotype Is AA And His Wife's Genotype Is AS But Their Daughter is SS by subbieD(f): 2:16pm On May 12, 2015
Im sure der must b an error sumwhere, Cos it's really odd sortof
Re: Help! His Genotype Is AA And His Wife's Genotype Is AS But Their Daughter is SS by peedeeasobie(m): 2:16pm On May 12, 2015
Once in a blue moon, a gun without bullet kills someone!
Earth! 0000- 2015 to infinity
Re: Help! His Genotype Is AA And His Wife's Genotype Is AS But Their Daughter is SS by Elslim: 2:16pm On May 12, 2015
SIRICE:
yes maybe his brother

he should go for a DNA test 1st
Re: Help! His Genotype Is AA And His Wife's Genotype Is AS But Their Daughter is SS by Geesanni: 2:16pm On May 12, 2015
UR WIFE MIGHT ALSO B AC,NOT AA AND D CHILD MIGHT B SC NOT SS.U KNW MOST LAB DAT ARE NOT STANDARD(EVEN OVERSEA) MIGHT NOT KNW MUCH ABT AC AND JST JUMP TO CONCLUSION DAT IT IS AA SINCE IT'S NOT D POPULAR AS ,JST LIKE THEY MIS- DIAGNOSE ASTHMA AND SICKLE CELL IST DIAGNOSE.TAKE UR TIME ND GO TO MANY EXPERIENCE DIFFERENT HOSPITAL BT U NEED TO B PATIENT ND NOT IN AN HURRY FOR D RESULT JST LIKE IMPREGNATING A GIRL WEN U STILL USE PROTECTION.
Geesanni:
technically looking at ur situation,since d wife is d aa,there is no way she cheated cos d child isnt carrying any of her genotype.assuming u re d aa,then confusion is somewhere.she might still b as not aa,but if more test confirmed that she is aa,then she has a trace of 's' genotype in her lineage which sometime mk one to have of baby of a different gene sth,it happens once in a while.to confirm this, u can test some of her grand-family(her father's/mother's brothers or sisters) if still available to knw if dey are carrier of 's' genotype,if yes she has a recessive of s,which means shehas a chance of having s- child jst like albinos.

1 Like

Re: Help! His Genotype Is AA And His Wife's Genotype Is AS But Their Daughter is SS by femi4: 2:16pm On May 12, 2015
pbs4real:
didnt u hear the man and his wife ran another test to confirm dre genotype again. . .wat else do u wnt them 2 do?
Na today? Test kit do malfunction and we have many crude medical officers these days
Re: Help! His Genotype Is AA And His Wife's Genotype Is AS But Their Daughter is SS by yassinattah(m): 2:17pm On May 12, 2015
according to mendelian law it isn't pocibu bt hematologically speakin their r various types of hemoglobinopathies,including the sickled cell disease,thalasemias,methemoglobulinemia etc.My candid opinion on dis matter is dt d couple shudnt use d baby's genotype as an avenue 4 their seperatn as notin is impossible in d site of God.well sumx science fails BT not God
Re: Help! His Genotype Is AA And His Wife's Genotype Is AS But Their Daughter is SS by tunergy(m): 2:19pm On May 12, 2015
FactorVIII:
1. @Demichaels pls tell your friend to ask his doctor to check him for alpha thalassemia
2. I am almost certain he has that.
3. alpha + thalassemia is usually harmless, it is caused by alpha gene deletions or in some cases dysfunctional alpha gene. However, people (the child in this case ) who inherit combinations of hb S (ie from the mother in this case ) may have hemoglobin disorder.
4. Hemoglobin electrophoresis is normal, DNA analysis is needed to be certain
5. Since a paternity test has been done here, infidelity resulting to the birth of the child can be safely ruled out.
6. This is simple Hematology.
7. Pls go to Hematology department LUTH to confirm, you will meet my professors and doctors, they are nice people
8. @ some nairaland peeps. pls if you are not enlightened on a particular subject, pls read abt it instead of judging people and using words like "impossible"
9. I really hope you see this. it can save your friend's marriage.

IWE! IWE!! IWE!!! (BOOK! BOOK!! BOOK!!!)

CAN YOU TRANSALATE TO ENGLISH PLEASE.
Re: Help! His Genotype Is AA And His Wife's Genotype Is AS But Their Daughter is SS by abbey621(m): 2:23pm On May 12, 2015
I can guarantee that the medical practitioners screwed up! First of all, there's no way an AA and an AS can bring about an SS, it's not possible anybody that say's otherwise is insane! Now when we speak of AC or SC that's a different story. They all need to recheck their genotype at an internationally approved facility. Something is not right here! If the child is truly the result of both individuals coming together then a medical error has occurred.

1 Like

Re: Help! His Genotype Is AA And His Wife's Genotype Is AS But Their Daughter is SS by Certifiedboss: 2:28pm On May 12, 2015
Demichaels:
My friend's 10 year Marriage is about to collapse.

His, my friend's genotype is AA and his wife's genotype is AS but their 4 year old daughter has been confirmed to have SS genotype by not less than 4 different medical experts. He confronted the wife and accused her of infidelity but she vehemently denied having any affair with another man. In other to prove her wrong, my friend subjected the little girl to a paternity test and there he got the shock of his life - the result showed he actually is the father of the girl. At first he accused the doctor of compromise because he is their family doctor and somehow relates to the wife. He then decided to go to another hospital to prove the paternity of the girl child there and then he got another shocker - the first result was actually correct. As It stands, my friend has consulted more than five other doctors outside the state of his residence and all Confirmed that the girl's genotype is SS and he actually is the father of the child despite his and the wife's genotype being as stated above. Even the doctor's are confused by the results as it negate conventional medical norm.

My question now is, experts in the house, is there anything that can lead to such unconventional biological flaw? Under what condition can AS and AA couple have an SS child? Can mutation lead to such condition? My friend insists on divorce because he doesn't believe the wife. Should he go ahead based on what we all know about genotype?


Please I need matured advice on this. This is a REAL LIFE SITUATION AND NO FICTION. I WOULD HAVE MENTIONED NAMES AND ADDRESS OF THE COUPLE BUT I DON'T HAVE THEIR PERMISSION YET. THIS IS HAPPENING RIGHT HERE IN PORT HARCOURT OLD GRA WE'RE LIVING


Medically it's impossible

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