Good news, men: you may be able to decrease your risk for prostate cancer by ejaculating — frequently, according to research presented here at American Urological Association 2015 Annual Meeting.

The frothy advice is not new but is now backed up by the "strongest evidence to date" on the subject, according to lead author Jennifer Rider, ScD, MPH, an epidemiologist at the Harvard T.H. Chan School of Public Health in Boston.

"There is no modifiable risk factor for developing prostate cancer," Dr Rider told Medscape Medical News. "It would be exciting to tell men that there was a way to modify their risk."

However, she noted that these are observational data and urged caution when "interpreting them."
During the study period, 3839 men have been diagnosed with incident prostate cancer, 384 cases of which were lethal.

At recruitment in 1992, all participating men were asked to report their average monthly frequency of ejaculation from the ages of 20 to 29 years and 40 to 49 years, and during the previous year. A lifetime average was then computed from these reports.

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After potential confounders were controlled for, the risk for prostate cancer was 20% lower in men who ejaculated at least 21 times a month than in men who ejaculated 4 to 7 times a month. The 20% risk reduction was seen at ages 20 to 29 and 40 to 49, and for the lifetime average (P trend < .0001 for all).

At ages 40 to 49, men most (38.0%) reported 8 to 12 ejaculations per month; only 8.8% reported at least 21 ejaculations per month.

"We shouldn't dwell on the exact numbers of ejaculation, but instead should focus on the dose–response relation," Dr Rider advised.

She summarized: "Safe s*xual activity could be good for prostate health."

Notably, there was no association between ejaculation frequency and the risk for high-grade, advanced, or lethal disease, she reported. The reason for this exception is not known.

These results are an update of the last major report from the Health Professionals Follow-up Study, which was published about 10 years ago (JAMA. 2004;291:1578-1586). At that time, investigators concluded that "high ejaculation frequency may possibly be associated with a lower risk of total and organ-confined prostate cancer," as reported by Medscape Medical News.

The Science of Orgasm, written by Barry R, Jinusayrjm Carlos Beyer-Flores, and Beverly Whipple, cited research from the late 70s that found mortality risk was 50 percent lower among men who had frequent orgasms (two or more per week), even when controlling for other factors such as age and smoking.

But how exactly could ejaculation protect against cancer? The orgasm itself has protective benefits, Dr. Rider said. Research shows the hormones oxytocin and dehydroepiandrosterone (DHEA) are released during orgasm; oxytocin has the power to lower blood pressure in women, reducing their risk for cardiovascular disease at the same time, while DHEA has been linked to lower risk for breast and cervical cancer.

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