Male contraceptive is a form of male birth control method for preventing pregnancy, common male contraceptive methods are vasectomy and the use of condom. Vasectomy is a surgical procedure for male sterilization, it is a permanent method. Condom is a sheath-shaped barrier device used during sexual intercourse to prevent pregnancy, it is not 100% reliable.

A compound called EP055 binds to sperm proteins to slow the motility of the sperm without affecting hormones. According to the lead investigator, Michael O’Rand, PhD, retired professor of cell biology and physiology in the University of North Carolina at Chapel Hill School of Medicine, and president/CEO of Eppin Pharma, Inc, the compound turns off the sperm’s ability to swim and limit fertilization.

Hormonal drugs made from the compound in clinical trials target the production of sperm without affecting the natural hormones in men. Thirty hours following a high-dose intravenous infusion of EP055 in male rhesus macaques, O’Rand and researchers in the Oregon National Primate Research Center at OHSU in Portland, Oregon, found no indication of normal sperm motility without side effects and the sperm motility is reversible by discontinuing taking the drug.
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