found out we are not compatible medically, tried seperating but seems impossible advice is urgently needed

I am so sorry to hear this, it is realy sad, however, it is called a tough love, cos i will never advice u guys to go ahead with such love at all, marriage like that is not fair at all, cos you and your patner will not be the one to suffer the consequences, it will be the children, the pain that comes with being a Sickle Cell kids is not funny at all, and i am so sure u will hate to see that happen, it is not cheap either to take care of them, so my honest advice is put an end to the relationship, u could remain friends, it is rather unfortunate, but better to prevent a bad tomorrow now, i realy feel for you guys, and i wish you both the best of luck
If you are AS, better to hook up with AA
if you are SS better to still hook up with AA.