Сan xanax withdrawal cause heart palpitations? Xanax withdrawal initiates a complex adjustment within the nervous system, and heart palpitations can be one of its expressions. The absence of benzodiazepine disrupts the equilibrium, prompting fluctuations in heart rhythm. Acknowledging these manifestations as part of the withdrawal journey emphasizes the need for careful observation and medical supervision to navigate the intricacies of the body's adaptation process safely.