skillmyman:
my wife and I found out we are both AC before we got married 8 yrs ago. i did some research on the internet about this and found out that it was not really a fatal condition except that ur kids have chances of being a CC. CC has aneamic condition and are allergic to a lot of stuffs.

We have two kids now, the eldest is AC while the younger is not old enough for us to check his genotype.

cheers

WRVUK:
I got an amazing result that i am CC and my girlfriend is AS. pls someone tell me if we are compatible. i am really worried

Sanchez01:


AA + AA = AA, AA, AA, AA
AA + AS = AA, AS, AA, AS
AA + SS = AS, AS, AS, AS
AA + AC = AA, AA, AA, AC
AS + AS = AA, AS, AS, SS
AS + SS = AS, SS, SS, SS
AS + AC = AA, AC, AS,SS
SS + SS = SS, SS, SS, SS
AC + SS = AS, AS, SS, SS
AC + AC = AA, AC, AC, SS

SC, SS, or CC are Sickle cell diseases (a recessive disorder) – a very serious medical condition with high prevalence rate in sub Saharan Africa. This is why intending couples must make sure to know their genotype and blood group compatibility before going ahead with marriage.

Don't really know how best to answer you here.

Emmion:
@ FSB,

thanks a great deal for the information. I have been looking for someone like you to help out. There is this lady i have been seeing for a while. I love her so much and marriage ASAP is already in my plans but there is the problem of genotype. This breaks my heart so much. I have gone for genotype test 3 times. First one i was given AC. Second was AA. Wanting to be doubly (or triple sure), i went for a third test and it turned out to be AC. Now my girlfriend also is AC. For me thats a problem. My parents are both AA. My elder brother is AA. So where did i get the AC from? I am confused. I love this girl but dont want pains for her and myself later when we start having children.

Please, i desperately need immediate advice. Any other Doctor in the house pls help.


Nothing do you my brother. Your fear is the possibility of having a child with CC genotype. Since you and your girlfriend are AC. For your information CC is not SS. I happen to be a living withness and good example of someone with CC genotype. I am fit and very healthy and I have never been admitted in any hospital. The only thing is occasional jaundice. I got to know about this when I was in University. In nutshell stick to your girl if you really love her.

Emmion:
@ FSB,

thanks a great deal for the information. I have been looking for someone like you to help out. There is this lady i have been seeing for a while. I love her so much and marriage ASAP is already in my plans but there is the problem of genotype. This breaks my heart so much. I have gone for genotype test 3 times. First one i was given AC. Second was AA. Wanting to be doubly (or triple sure), i went for a third test and it turned out to be AC. Now my girlfriend also is AC. For me thats a problem. My parents are both AA. My elder brother is AA. So where did i get the AC from? I am confused. I love this girl but dont want pains for her and myself later when we start having children.

Please, i desperately need immediate advice. Any other Doctor in the house pls help.

Obidonreal:
There's no such thing as genotype AC

Sanchez01:


AA + AA = AA, AA, AA, AA
AA + AS = AA, AS, AA, AS
AA + SS = AS, AS, AS, AS
AA + AC = AA, AA, AA, AC
AS + AS = AA, AS, AS, SS
AS + SS = AS, SS, SS, SS
AS + AC = AA, AC, AS,SS
SS + SS = SS, SS, SS, SS
AC + SS = AS, AS, SS, SS
AC + AC = AA, AC, AC, SS

SC, SS, or CC are Sickle cell diseases (a recessive disorder) – a very serious medical condition with high prevalence rate in sub Saharan Africa. This is why intending couples must make sure to know their genotype and blood group compatibility before going ahead with marriage.

Don't really know how best to answer you here.

lepasharon:


You are very wrong. The hemoglobin type C is a a variant of hemogloin on its own and has nothing to do with sickle cell cell disease. Stop it

Obidonreal:
There's no such thing as genotype AC

napa:
Please is there any thing like genotype AC

napa:
Please is there any thing like genotype AC

lepasharon:


You are very wrong. The haemoglobin type C is a a variant of hemogloin on its own and has nothing to do with sickle cell cell disease. Stop it

youseuph:

You not totally correct. CC is not a very serious medical condition as you put it. I rep CC genotype and am as fit as fiddle, though with occasional jaundice.

Sanchez01:

So you think I pulled that without a source
http://glowville.net/what-you-must-know-about-genotype-and-blood-group-compatibility/

fsb:
How do people get their genotypes?

Simple, from your biological parents.

If papa bomboy has a genotype AA and mama bomboy has a genotype AS, which genotype do their children have? What we do in theory is this, you cross each of those letters so that you have AA, AS, AA, AS? Therefore, for each pregnancy and each bomboy they delivery has a 50:50 probability of being AA or AS.

What if their genotypes were AA (for papa bomboy) and SS (for mama bomboy); you do the crossing again: AS, AS, AS, AS. Therefore, it is very UNLIKELY that any of their children will have a genotype outside of AS.

You will see that I have used the word unlikely because SHIT happens. They might end up having a child who is either completely AA or SS but whatever happens, a child's genotype is never outside of the parents. Eg. a man and woman who are both AA can never have children with genotype starting or ending with 'S'. If it happens, talk to your landlord (just kiddin').

So for you to get AC, you must have a parent who carries a 'C' in his or her genotype. I hope that answers your question?

One more thing: Are there any clinical features of Hemoglobin C like Hemoglobin S?

In the case that you're AC, well the good news is that MOST TIMES THERE ARE NO SYMPTOMS, but occasionally, there is JAUNDICE.

THE BEST PART IS THAT YOU CAN LIVE A NORMAL LIFE WITH AC!!!

Hope that has helped!!!


, fsb

Sanchez01:



Genotypes associated with clinical features: SS, SC, CC (are associated with clinical signs, symptoms and syndromes)

Please note that the marriage thing is this, we really don’t know what the recent trend is but the important thing is to make sure your genotype of you and your partner don’t match up in a way as to produce children with SS, SC and CC.
These children only suffer for nothing!!!

You can’t even begin to compare the differences in severity between CC and SS disease,
Symptoms of Hemoglobin C dsx (CC)
Most people do not have symptoms. Occasionally, jaundice may occur.
Complications of Hemoglobin C dsx
Sometimes, they may experience the following:
Cholelithiasis (gallstones that may require treatment)
Splenomegaly (big spleen)
Angloid streaks (causing poor vision)
Aplastic crises (due to viral infection): episode of severe anaemia

Treatment

There is no treatment. Folic acid supplementation is required to help the body with red blood cell production and improve symptoms of anaemia.

Prognosis
Note that unlike the Haemoglobin S dsx (SS), pxts with Hemoglobin C dsx have a normal life expectancy,
Before we forget, what about SC genotype?
Please note the following:

AA: normal pxts
AS: don’t show any symptoms
SS: sickle cell disease (sicklers)
AC: don’t show any symptoms
CC: described above

SC? This condition is associated with recurrent anaemia (breakdown of red cells in the blood vessels) and pain crises (vaso-occlusive crises). Some may also experience aseptic necrosis of the thigh bone (femur).

The summary is that it is bad!

One thing you must understand is that in terms of geographic distribution, the haemoglobin C allele is found at the highest frequencies in West Africa and it has been associated with protection against malaria.

A good number of people have the C allele but are unaware of it.
Also note that most people with the AC genotype show no symptoms,

PLEASE NOTE THIS AND HELP SHARE WITH A FRIEND

A man or woman with AS or AC or SS or SC or CC (very rare) cannot marry each other if they want to avoid SS or SC.

They must marry a partner with AA if they don’t want to born a child with Sickle cell syndrome.

If AS or AC marry each other, they have 25% chance of having a sickle child at every birth. If they marry SS or SC, they have 50% chance of having a sickle cell child at every birth.

Please note all their kids could be AS AC or AA.

If SS or SC marry each other, it’s is nothing other than a terrible disaster.
All their children will have Sickle cell.

SC and SS are almost the same only that SS suffers more severe crisis than SC carrier. You might not notice the presence of the disease on the body of SC carrier, unlike in SS.
http://healthematics.com/the-as-ac-sc-ss-and-cc-genotype/

NB: I'm not a medical practioner and I didn't write the points raised above.

orimahspence:
,I have had several genotype test before ,I used to be AS
just last year I went for a test and result shown to be SC, so suprised , I'm as fit as fiddle, I'm not a sickler , that's when I stop taking this genotype things serious

tomdon:



Thanks doc
Please how can people who have AC genotype improve quality of life