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Zika infection typically results in mild or symptom-free infections in healthy individuals, infected pregnant women without symptoms may still give birth to a baby with birth defects like microcephaly.

Researchers has shown that a potential Zika vaccine can protect fetuses against infection and protect males against testicular infection and injury. It also prevents a lowered sperm count after one vaccination.

Infected men without any signs of illness may still incur testicular injury and lowered sperm count. The Zika virus could infect the male reproductive system for several months, posing risk for sexual transmission.

Taking a single-dose vaccine could prevent Zika infection in non-human primates, prevent mother-to-fetus transmission, and stop male testis infection in mice. The vaccine provides a protective immune response, this vaccine exhibited an excellent safety profile in mouse and non-human primate models.
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